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Skin is a significant part of a body involve protect yourself from foreign body and harmful substance also maintains the physiological function like body temperature and preserve skin moisture. However, some factor, progressive the aging involves internal and external factor and their interactions, affecting a human individual from conception to death as well as the response of the human body to these factors that lead to decreases, the skin function, Appearance of wrinkles, sagging and hyperpigmentation make biological and clinical signs of skin aging. Now the medical science and technology is change and develop using therapy technique and cosmetic product like Botox, fillers, collagen, Hyaluronicacid and Mesotherapy improve skin tone and reduce aging signs and symptoms.