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Globally, infertility affects 8-12% of couples of reproductive age and has become a common problem. There are several ways to treat infertility, including medication, intrauterine insemination, and in vitro fertilization. In recent years, stem cells are looked at as a promising tool for improving infertility treatments in women and men.. Stem cells are self-renewing, self-replicating undifferentiated cells that are capable of producing specialized cells under appropriate conditions. They exist throughout a human’s embryo, fetal, and adult stages and can proliferate into different cells. While many issues remain to be addressed concerning stem cells, stem cells have undeniably opened up new ways to treat infertility. In this review, we describe past, present, and future strategies for the use of stem cells in reproductive medicine.