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This book describes the coming about and first results of the AiREAS "healthy city" cooperative in the city of Eindhoven and Province of North Brabant in the Netherlands. AiREAS is an initiative focused on the multidisciplinary co-creation of healthy cities using the core human value of human health and air quality as guiding principle for profound regional innovation. The unique group process that followed uses the complexity of the city of Eindhoven as living lab. It is an anthropology based initiative that invites directly to the same table of core innovative responsibility the local government, innovative business partners, scientific insights and reseach, and civilian participation.