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This volume explores the different ways in which the contingency of life, and especially human life, is relevant for ethical discussions and the normative frameworks of bioethics. It explores the relevance of the notion of contingency, and the desire for moral argumentation within bioethics. The authors discuss these notions from a philosophical perspective, paying special attention to the impact of life sciences on people with disabilities and to intercultural perspectives on bioethical debates. The volume also contributes to a deeper reflection on the basic philosophical assumptions of bioethics.