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The inaugural volume in the Issues of Diversity in Clinical Neuropsychology series, Principles of Neuropsychological Assessment with Hispanics sheds needed light on challenges specific to assessing members of this growing, diverse population. Beginning with evidence-based findings revealing intricate nonlinear relationships between culture and the brain, Antolin M. Llorente and a team of eight experts explore finely nuanced constructs of culture, ethnicity, race, and language among Hispanics in neurobehavioral and neurocognitive terms. The authors ably balance theory, research, and practical applications, and give ample space to ethical issues in the assessment of Latinos, indicating the ongoing need for bias-free procedures so that evaluations—and the treatment interventions that they generate—are accurate and valid.