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This volume provides readers with selected fuzzy and rough tools used to medical tasks, especially diagnosing and medication. To build a link between theoretical, mathematical excerpts and practical medical applications, the contents is formed as a sequence of occurrences in which a patient appears to be diagnosed and cured. The fuzzy and rough elements are inserted in the book in the order required by the presentation of medical substance to maintain the logical unity of the book’s essence. In conformity with this pattern the essay presents in turn some necessary elements of fuzzy set theory, the classical fuzzy diagnostic model with extensions, the fuzzy diagnostic model with clinical examinations extended throughout time based on distance theory, methods of drug effectiveness measurements and algorithms selecting the optimal medicine. As the complement, the solution of an approximation problem is suggested to find a curve that surrounds two-dimensional clock-like point sets with the little approximation error.