Publication year: 2022
: Ph00162
Pulmonary alveolar proteinosis (PAP) is a rare respiratory syndrome characterized by the accumulation of surfactant lipoproteins within the alveoli. Primary PAP is led by a granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling disruption. Secondary PAP is associated with various diseases causing a reduction in function and/or the number of alveolar macrophages. Congenital PAP emerges as a consequence of corrupted surfactant production, due to mutations affecting surfactant transporter or lung development.
: Pulmonary Alveolar Proteinosis, Lung diseases, Lung, Etiology, Diagnostic imaging, Therapeutics