Book Details

Specialization and Complementation of Humoral Immune Responses to Infection

Publication year: 2008

: 978-3-540-73900-5

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In recent years the results of past studies on T cell dependent and T cell independent antibody responses have coalesced with discoveries regarding the roles of various primary B cell subsets and components of the innate immune system in conferring resistance to infectious pathogens. As a consequence, a new and more complete understanding of how antibody-mediated resistance to pathogens is elaborated has emerged. The recent explosion of knowledge of Toll-like receptor specificity and function has further embellished this understanding. It is now clear that there is not only extensive overlap and cross-complementarity in the action of innate and adaptive immune systems, but also specialization of function of the various B cell subsets and the types of antibodies they produce. This synergistic interaction of multiple components of these systems is perhaps best exemplified in antibody responses to bacteria.


: Biomedical and Life Sciences, Antigen, B cells, T cells, bacteria, borrelia infection, complement, immunization, infection, infections, infectious, natural killer, streptococcus infection, toll-like receptor, tumor necrosis factor, vaccine