The Use of Tissue Transglutaminase Antibodies in Monitoring the Adherence with Gluten-free Diet in a Group of Children with Celiac Disease
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Author |
Challar M.H.; Jouma M.; Chahine E. |
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Published in |
Journal of Laboratory Diagnosis, Volume 3, Issue 4, July 2004 |
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Abstract |
Background: Celiac disease is a syndrome characterized by a damage of the small mucosa caused by wheat, barley or rye ingestion in genetically susceptible subjects. Elimination of this cereals from their diet results in full mucosal recovery. It was demonstrated that tTG has a very high diagnostic accuracy for celiac disease and for patients adherence to a gluten-free diet. Objective: To assess the adherence to a gluten-free diet by using IgA-Class tTG antibodies before and after the adherence to a gluten-free diet in a group of children with celiac disease. Subjects and Methods: ELISA test for IgA-Class tTG antibodies were measured for 19 children who have a biopsy proven celiac disease (mean age 9.6 years, range 2.5 – 17 year) before and after the adherence to a gluten-free diet. Results: The tTG antibodies titers were decreased to a normal range in only 37% of the subject group. Conclusion: We estimate that 63% of the subject group have a bad adherence to the gluten-free diet, although the mentioned that they complied with the diet. |
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