Authors

Al-Sharra S.; Juma M.EL.; Al-Quobaili F.

Published in

Journal of Laboratory Diagnosis, Volume 6, Issue 4, January 2012

Abstract

Glycated LDL is produced by attachment of glucose molecule with low density lipoprotein (LDL). When LDL and diabetes mellitus (DM) are important risk factors in coronary artery disease (CAD), so we aim to investigate Glycated LDL levels.
The study included 23 patients with DM type 2 and CAD, 17 patients with DM and without CAD, 27 nondiabetic patients with CAD and 36 apparently healthy controls. Glycated LDL, HDL, LDL, total cholesterol and triglycerides were measured. Glycated LDL levels showed considering rising in diabetic CAD group (P = 0.007) and nondiabetic CAD group (P= 0.01) in compare with diabetic non CAD group and control group (1.41mg/dl, 1.49 mg/dl, 1.13 mg/dl and 1.09 mg/dl, respectively).
There was considering direct relation for glycated LDL with number of injured coronary arteries for diabetic CAD group and nondiabetic CAD group (R=0.4; P=0.05; R=0.5; P=0.01 one by one), and relation was direct too for glycated LDL with LDL and total cholesterol for four groups. There were no relations with triglycerides and HDL. These results indicate to be a relation between high glycated LDL level and occurrence of coronary artery disease.

Link to read full paper

http://scla.org.sy/magazine/issues/6_4/428.html