A Study of the Probable Role of PSA in Breast Cancer
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Authors |
Abdalla Sh.; Alakhras G.; Jomaa M. |
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Published in |
Journal of Laboratory Diagnosis, Volume 4, Issue 6, July 2007 |
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Abstract |
PSA is the most valuable tumor marker to detect prostate cancer in the early stages. It has been used to evaluate disease progression and responsiveness to treatment, in addition to predict tumor relapse. Recently few published results have demonstrated the presence of PSA expression in numerous human tumor types, healthy tissues, biological fluids and cell lines, in less concentration than in porstate or seminal fluid. This study was carried out on 105 women whom were divided into 5 groups. Serum concentrations of CA15-3, free and total PSA were measured using ready kits (ELECSYS) that apply electro-chemi- luminescence detection. Our study revealed that there is no role for PSA in breast cancer either in diagnoses or monitoring the progress of the disease. On the other hand, the levels of CA15-3 can be used in the early detection of tumor relapse in breast cancer stage III patients and to evaluate prognosis. But it can't be considered a reliable marker for early detection of the disease. CA15-3 can be helpful in breast cancer monitoring of the treatment, especially in stage ?V patients, with high levels of the tumor marker, in which there was a dramatic decrease in its levels after chemical treatment. This can be explained as a result of removal of the diseased tissue and successful treatment. |
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