الصفحة 1
الصفحة 1
Natriuretic Peptides : The Hormones of the Heart
The rapid knowledge in the field of neuro-humoral regulation of cardiovascular pathophysiology is changing the picture of current diagnosis and treatment of cardiac patients. The emerging conceptual revolutionary idea is that heart acts not as a pump, merely, but as a "gland", that is as a regulator of circulatory homeostasis and salt-water balance. Cardiovascular pathophysiology has to be written, indeed, on this basis: this physiology textbook gives an up-to-date description of the complexity and novelty of actual knowledge, with all its potential clinical implications.
Investigative Electrocardiography in Epidemiological Studies and Clinical Trials
It reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.
Insights into Receptor Function and New Drug Development Targets
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function. The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.
Fetal compromise in labor
Sixty years ago, the purpose of introducing electronic fetal heart rate monitoring (EFM) was to reduce the incidence of intrapartum stillbirth. However, by the early 1980s, with falling stillbirth rates, fetal blood sampling had been widely abandoned, as many considered that EFM was sufficient on its own. Unfortunately, while the sensitivity of EFM for the detection of potential fetal compromise is high, specificity is low, and there is a high false positive rate which has been associated with a rising cesarean section rate. The authors suggest that EFM is considered and analyzed as a classic screening test and not a diagnostic test. Furthermore, it requires contextualization with other risk factors to achieve improved performance. A new proposed metric, the Fetal Reserve Index, takes into account additional risk factors and has demonstrated significantly improved performance metrics. It is going through the phases of further development, evaluation, and wider clinical implementation.
Electrical Diseases of the Heart : Genetics, Mechanisms, Treatment, Prevention
Electrical Diseases of the Heart is a thorough clinical reference on the current status of cardiac electrophysiological disease,emphasizing common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology, and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science.
Earthquake alert with smartwatch = تنبيه الزلازل باستخدام الساعة الذكية
After the recent events and earthquakes that affected the region, resulting in the deaths of many individuals due to the lack of timely emergency response, the idea for this project emerged Earthquake Alert with Smartwatch. Initially, our application gathers information about the user, such as age, family members, and any existing medical conditions. In the event of an earthquake, the application sends an alert to the user. It receives earthquake information, such as ‘magnitude, time, location…’ from United States Geological Survey “USGS” through an API. If the user is within the geographical area affected by the earthquake, the application will assist the Smartwatch in calculating vital signs such as ‘heart rate and blood pressure’. Additionally, there is another artificial intelligence model that receives the user's audio recordings and converts them into written texts. All this information, along with the user's geographical location, will be sent to the nearest emergency point for the purpose of aiding those individuals trapped under the rubble.
Diabetes genetic finder & predictor = أداة البحث والتنبؤ الجيني لمرض السكري
The diabetes genetic finder & predictor app is a comprehensive, user-friendly solution that revolutionizes diabetes care. This powerful app integrates a wide array of features designed to empower diabetes patients and enhance their overall well-being. A standout feature of the app is its ability to predict the risk of hereditary diabetes diseases, offering users early detection and intervention opportunities. It also predicts general diabetes risk, diabetic foot complications, and retinopathy. Users can monitor their blood sugar levels, heart rate, and oxygenation either manually or through smart watch integration. Additionally, users can enter their diabetes type and HbA1c levels.The app's medication management feature simplifies the complex task of tracking and organizing medications, providing timely reminders to ensure adherence to treatment plans. Users can scan QR codes on products to check their sugar content and suitability, schedule their medications, generate reports for specific periods, and access a comprehensive list of frequently asked questions about diabetes..
Current News in Cardiology ; Proceedings of the Mediterranean Cardiology Meeting 2007 (Taormina May 20-22, 2007)
Aim of the volume is to give an overview of the state of the art on the emerging cardiac pathologies such as acute coronary syndromes, atrial fibrillation, sudden death, heart failure, global cardiovascular prevention and syncope. The volume chapters offer the latest information about epidemiology, pathophysiology, diagnosis and novel treatments of these pathologies.
Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics
In this newly updated second edition of Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, William B. White, MD, and a panel of highly distinguished clinicians give a critical review of every aspect of the evaluation of high blood pressure. This includes home and ambulatory blood pressure monitoring, the relationship between whole-day blood pressure and the cardiovascular disease process, and the effects of antihypertensive therapies on these blood pressure parameters. World-class contributors describe the significant advances in our understanding of the circadian pathophysiology of cardiovascular disorders and demonstrate that ambulatory blood pressure values are independent predictors of cardiovascular morbidity and mortality.
Advances in Cardiac Signal Processing
Deals with the acquisition and extraction of the various morphological features of the electrocardiogram signals.In the first chapters the book first presents data fusion and different data mining techniques that have been used for the cardiac state diagnosis. The second part deals with heart rate variability (HRV), a non-invasive measurement of cardiovascular autonomic regulation. Next, visualization of ECG data is discussed, an important part of the display in life threatening state. Here, the handling of data is discussed which were acquired during several hours. In the following chapters the book discusses aortic pressure measurement which is of significant clinical importance. It presents non-invasive methods for analysis of the aortic pressure waveform, indicating how it can be employed to determine cardiac contractility, arterial compliance, and peripheral resistance. In addition, the book demonstrates methods to extract diagnostic parameters for assessing cardiac function. Further the measurement strategies for contractile effort of the left ventricle are presented. Finally, the book concludes about the future of cardiac signal processing leading to next generation research topics which directly impacts the cardiac health care.
