الصفحة 1
الصفحة 1
Natural anti-aging skin care
Ageing is a natural phenomenon which is a fold, ridge and crease in the skin that occurs due to loss of body mass, poor hydration, disintegration of dermis and epidermis junction. The Skin ageing process involves many changes that occur due to the combination of both endogenous factors and exogenous factors. The ageing of the skin occurs due to various mechanisms like glycation, free radical, cell cycle, and cellular and molecular mechanism of skin ageing. In this review article, we have discussed the treatment, worldwide newer therapies and marketed formulation that are currently available for the reduction of skin ageing.
Multinational Enterprises, Foreign Direct Investment and Growth in Africa : South African Perspectives
How can Africa, the world’s most lagging region, benefit from globalisation and achieve sustained economic growth? Africa needs greater investment by Multinational Enterprises (MNEs) to improve competitiveness and generate more growth through positive spill-over effects. Despite the fact that Africa’s returns on investment averaged 29% since 1990, Africa has gained merely 1% of global Foreign Direct Investment (FDI) flows. The challenge for African countries is how to be a more desirable destination for FDI. The study integrates three currents of economic research, namely from the literature on (endogenous) economic growth, convergence and regional integration, the explanations for Africa’s poor growth and the growing understanding of the role of MNEs in a global economy. The empirical side of the book is based on an econometric study of the determinants of FDI in Africa as well as a detailed firm-level survey conducted in 2000.
Money, Banking, and Financial Markets : A Modern Introduction to Macroeconomics
Introduction to money, banking, and financial markets, with a special emphasis on the importance of confidence and trust in the macroeconomic system. It also presents the theory of endogenous money creation, in contrast to the standard money multiplier and fractional reserve explanation found in other textbooks. The U.S. economy and financial institutions are used to explain the theoretical and practical framework, with international examples weaved in throughout the text. It covers key topics including monetary policy, fiscal policy, accounting principles, credit creation, central banks, and government treasuries. Additionally, the book considers the international economy, including exchange rates, the Eurozone, Chinese monetary policy, and reserve currencies. Taking a broad look at the financial system, it also looks at banking regulation, cryptocurrencies, real estate, and the oil and gold commodity markets. Students are supported with chapter objectives, key terms, and problems.
Insights into Receptor Function and New Drug Development Targets
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function. The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.
Hormones and the brain
Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging. Depending upon intensity and duration of exposure, they can be either neuroprotective or neurotoxic, for instance by affecting production of free radicals. This book, based on contributions of pioneer investigators in the field, outlines the ambiguous actions of gonadal steroids (estradiol, progesterone, testosterone, inhibin and activin) and of neurosteroids, related moieties produced in the brain itself. After summarizing their multiple mechanisms of action, which involve both direct effects on neuronal membranes and activation of genes coding for specific proteins in neurons or glial cells, the book outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Handbook of neurochemistry and molecular neurobiology : Development and Aging Changes in the Nervous System
In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.
Growth, Trade and Economic Institutions
Endogenous growth is examined from the viewpoint of economic history, institutions and international trade. The main results are the following. The variance in institutional quality can be explained by historical differences in biogeographical potential for early agriculture. The expansion of output can lead to dis-agglomeration. The patterns of growth are sensitive to the technology parameters of the capital-good industry. With capital intensive industries, the balanced growth path can exhibit local indeterminacy. Economies integrate, if the productivity of R&D does not vary too much for them. Other aspects examined are the equilibrium of a dynamic multi-sector economy, the political economy of employment protection and the relationship between technological change and the demand for skill-intensive activities.
Ghrelin more than hunger hormone
Ghrelin is a stomach hormone that acts as an endogenous ligand of orphan G-protein-coupled receptor. Ghrelin is a 28-amino acid peptide existing in two major forms: n-octanoyl-modified ghrelin, which possesses an n-octanoyl modification on serine-3 and des-acyl ghrelin. Fatty acid modification of ghrelin is essential for ghrelin-induced growth hormone release from the pituitary and appetite stimulation. This acyl-modification of ghrelin is catalysed by ghrelin-O- acyl transferase recently identified.
Experimenting with Dynamic Macromodels : Growth and Cycles
This book presents a macroeconomic dynamic model à la Solow-Swan, including the market for labour, in a discrete time structure. Labour supply is modelled as a reversed S curve (derived in the appendix). The models are expanded to include expenditure on R&D (thus endogenous technical progress), and public expenditure on infrastructures. For each of the three models, numerical simulations are implemented in MAPLE, and the results are shown in time series figures, which make it easy to detect that even small changes in the parameters produce responses in the time behaviour of the main variables: from steady growth, to regular cycles, to chaotic-like time paths. The simulations show that cycles do not promote material welfare, as measured by total undiscounted consumption along the time horizon, and that the comparative action of R&D versus public expenditure is strictly linked to the values assigned to the parameters.
Exogenous and endogenous factors affecting happiness, happy mind, happy life
Emotions are the language of the soul. Our brain is the emotional center where every emotion is produced including happiness. Happiness underlying factors are considerable from two dimensions: endogenous factors and exogenous factors Therefore, this research aimed to consider biological factors that underlie happiness. The research is divided into several sub-groups (brain, genetics, neurotransmitters, endocrinology, hormones, drugs, diseases, and other exogenous factors). In spite of difficulties in finding special genes, several genes distributed to emotion and mood. Neuroscience studies showed that some part of brain (e.g. amygdala, hipocamp and limbic system) and neurotransmitters (e.g. dopamine, serotonin, norepinefrine and endorphin) play a role in control of happiness. A few studies pointed to the role of cortisol and adrenaline (adrenal gland) and oxitocin (pituitary gland) in controlling happiness.
Evolution of Non-Expected Utility Preferences
The theory on the evolution of preferences deals with the endogenous formation of preference relations in strategic situations. In particular, we demonstrate that preferences which diverge from von Neumann-Morgenstern expected utility may potentially prove to be successful under evolutionary pressures.
Erythropoietins and Erythropoiesis : Molecular, Cellular, Preclinical, and Clinical Biology
The book is divided into two sections: Background and Basic Science and Clinical Uses of Recombinant Erythropoietins. To begin, Israels and Israels describe the biology of red cells, the hierarchy of erythropoietic progenitor cells, their development to mature cells, and the effects of endogenous EPO on their development. Foote summarizes the historical interest in, and search for, an erythropoietic factor. Once EPO was identified,cloned,and expressed,the path was set for the study of other aspects of EPO biology both within e- thropoiesis and other cellular systems.
Endogenous Public Policy and Contests
This book studies endogenous policy determination focusing on the role of interest groups and their lobbying efforts in the determination of public policy. Applying strategic contest theory, it clarifies the fundamental parameters that determine the behavior of the government and the interest groups - the two contestants for the "prizes" associated with public policy.
Dynamic Modeling of Monetary and Fiscal Cooperation Among Nations
The first four chapters introduce the reader to the dynamics of fiscal and monetary policy cooperation. Issues covered include: fiscal coordination, fiscal stringency requirements, structural and bargaining power asymmetries and the design of monetary and fiscal policymaking in a monetary union. In the four last chapters multiple-player settings with aspects of fiscal and/or monetary coordination are analyzed using the endogenous coalition formation approach. The analysis is focused on shock and model asymmetries and issues of multi-country coordination in the presence of (possibly many) monetary unions.
Dynamic General Equilibrium Modelling : Computational Methods and Applications
Modern business cycle theory and growth theory uses stochastic dynamic general equilibrium models. Many mathematical tools are needed to solve these models. The book presents various methods for computing the dynamics of general equilibrium models. In part I, the representative-agent stochastic growth model is solved with the help of value function iteration, linear and linear quadratic approximation methods, parameterised expectations and projection methods. In order to apply these methods, fundamentals from numerical analysis are reviewed in detail. Part II discusses methods for solving heterogeneous-agent economies. In such economies, the distribution of the individual state variables is endogenous. This part of the book also serves as an introduction to the modern theory of distribution economics. Applications include the dynamics of the income distribution over the business cycle or the overlapping-generations model.
Distribution and phenotype of proliferating cells in the Forebrain of adult macaque monkeys after transient global cerebral ischemia
The authors' results show that ischemia differentially activates endogenous neural precursors residing in diverse locations of the adult primate central nervous system. A limited endogenous potential for postischemic neuronal repair exists in neocortex and striatum, but not in the hippocampus proper of the adult macaque monkey brain. The presence of putative parenchymal progenitors and of sustained progenitors in germinative centers opens novel possibilities for precursor cell recruitment.
CO-ENZYME Q10
Coenzyme Q10 (CoQ10) is a fat-soluble compound that is synthesized by the body and can be obtained from the diet. Co-Q10 plays a central role in mitochondrial oxidative phosphorylation and the production of adenosine triphosphate (ATP). It also functions as an antioxidant in cell membranes and lipoproteins. Endogenous synthesis and dietary intake provide sufficient C0- Q10 to prevent deficiency in healthy people, although coenzyme Q10 concentrations in tissues decline with age. Oral supplementation of coenzyme Q10 increases coenzyme Q10 concentrations in plasma and lipoproteins. Oral high-dose co- Q10 is usually effective to treat mitochondrial disorders that are caused by mutations in coenzyme Q10 biosynthetic genes.
Macroeconomic modelling of R&D and innovation policies
This book encompasses a collection of in-depth analyses showcasing the challenges and ways forward for macroeconomic modelling of R&D and innovation policies. Based upon the proceedings of the EC-DG JRC-IEA workshop held in Brussels in 2017, it presents cutting-edge contributions from a number of leading economists in the field. It provides a comprehensive overview of the current academic and policy challenges surrounding R&D as well as of the state-of-the-art modelling techniques.
Competition, innovation, and antitrust : A theory of market leaders and Its policy implications
Competition, Innovation, and Antitrust develops a theory of market leadership in the presence of endogenous entry of firms and applies it to models of competition in the market and for the market.
Carbon monoxide in drug discovery, basics, pharmacology, and therapeutic potential
Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent.
