الصفحة 1
الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
On the move to meaningful internet systems : OTM 2008 Workshops ; OTM Confederated International Workshops and Posters, ADI, AWeSoMe, COMBEK, EI2N, IWSSA, MONET, OnToContent + QSI, ORM, PerSys, RDDS, SEMELS, and SWWS 2008, Monterrey, Mexico, November 9-14, 2008. Proceedings
This volume constitutes the refereed proceedings of 13 international workshops held as part of OTM 2008 in Monterrey, Mexico, in November 2008.The 106 revised full papers presented were carefully reviewed and selected from a total of 171 submissions to the workshops. The volume starts with 19 additional revised poster papers of the OTM 2008 main conferences CoopIS and ODBASE. Topics of the workshop papers are ambient data integration (ADI 2008), agents and web services merging in distributed environment (AWeSoMe 2008), community-based evolution of knowledge-intensive systems (COMBEK 2008), enterprise integration, interoperability and networking (EI2N 2008), system/software architectures .
On the Move to Meaningful Internet Systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part II
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
On the move to meaningful internet systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part I
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
Nuucleic acids in medicinal chemistry and chemical biology : Drug development and clinical applications
Delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Nonlinear Dielectric Phenomena in Complex Liquids
Complex liquids constitute a basic element in modern materials science; their significant features include self-assembly, mesoscale structures, complex dynamics, unusual phases and enormous sensitivity to perturbations. Understanding their nature and properties are a great challenge to modern materials science that demands novel approaches. This book focuses on nonlinear dielectric phenomena, particularly on nonlinear dielectric spectroscopy (NDS), which may be considered a possible successor to broadband dielectric spectroscopy (BDS). NDS phenomena directly coupled to mesoscale heterogeneity fluctuations, so information obtained in this way is basically complementary to BDS tests. The book also discusses the application of NDS in a set of complex liquid systems: glassy liquids, liquid crystals, liquids with critical point phenomena, and bio-relevant liquids. The complementary application of NDS and BDS may allow the discovery of universal patterns for the whole category of complex liquids. Written by specialists in the field of nonlinear dielectric studies, theoreticians and experimentalists, ranging from solid state physics to biophysics, the book is organized so that it can serve as a basic textbook for a non-experienced reader.
NF-kB/Rel Transcription Factor Family
Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.
New Techniques in Solid-State NMR
After the discovery of nuclear magnetic resonance, [1, 2] the new spectroscopy was used for the study of 1 H nuclei in liquids, but then the signal from copper in the receiver coil itself, the first observation of NMR in the solid state, was found.“Wide-line NMR”, named thus because of the line-broadening effects of dipolar interaction and chemical shift anisotropy, was not far behind, and soon led to significant advances through the analysis of spectral lineshapes. Inthis way Richards and Smith [3] demonstrated the presence of H3O+ cations in solid hydrates of strong acids, while Andrew and Eades [4] investigated the details of molecular motion in three solid benzenes. Even now, 50 years later, it is difficult to think of a technique which would provide a more convincing demonstration of the reality of these effects.
New Frontiers in Artificial Intelligence ; JSAI 2007 Conference and Workshops, Miyazaki, Japan, June 18-22, 2007, Revised Selected Papers
The technology of artifcial intelligence is increasing its importance thanks to the rapid growth of the Internet and computer technology. In Japan, the annual conference series of JSAI (The Japanese Society for Arti?cial Intelligence) has been playing a leading role in promoting AI research, and selected papers of the annual conferences have been published in the LNAI series since 2003. This book consists of award papers from the 21st annual conference of JSAI (JSAI 2007) and selected papers from the four co-located workshops.
New Drug Development for Known and Emerging Viruses
This book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic.
Neural Information Processing ; 14th International Conference, ICONIP 2007, Kitakyushu, Japan, November 13-16, 2007, Revised Selected Papers, Part II
The 228 revised full papers presented were carefully reviewed and selected from numerous ordinary paper submissions and 15 special organized sessions. The 116 papers of the first volume are organized in topical sections on computational neuroscience, learning and memory, neural network models ,supervised /unsupervised/reinforcement learning, statistical learning algorithms, optimization algorithms, novel algorithms, as well as motor control and vision. The second volume contains 112 contributions related to statistical and pattern recognition algorithms, neuromorphic hardware and implementations, robotics, data mining and knowledge discovery, real world applications, cognitive and hybrid intelligent systems, bioinformatics, neuroinformatics, brain-conputer interfaces, and novel approaches.
Neural Information Processing ; 14th International Conference, ICONIP 2007, Kitakyushu, Japan, November 13-16, 2007, Revised Selected Papers, Part I
The 228 revised full papers presented were carefully reviewed and selected from numerous ordinary paper submissions and 15 special organized sessions. The 116 papers of the first volume are organized in topical sections on computational neuroscience, learning and memory, neural network models, supervised/unsupervised/reinforcement learning, statistical learning algorithms, optimization algorithms, novel algorithms, as well as motor control and vision. The second volume contains 112 contributions related to statistical and pattern recognition algorithms, neuromorphic hardware and implementations, robotics, data mining and knowledge discovery, real world applications, cognitive and hybrid intelligent systems, bioinformatics, neuroinformatics, brain-conputer interfaces, and novel approaches.
Net-Centric Approaches to Intelligence and National Security
Net-Centric Approaches to Intelligence and National Security considers the web architectures and recent developments that make net-centric approaches for intelligence and national security possible. The development of net-centric approaches for intelligence, national & homeland security applications has become a major concern in many areas such as defense intelligence and national and international law enforcement agencies, especially since the terrorist attacks of 9/11. Net-Centric Approaches to Intelligence and National Security presents developments in information integration and recent advances in web services including the concept of the semantic web. Discovery analysis and management of web-available data pose a number of interesting challenges for research in web-based management systems. Intelligent agents and data mining are among the techniques employed. A number of specific systems that are net-centric based in various areas of military applications, intelligence and law enforcements are presented utlilizing one or more of such techniques Net-Centric Approaches to Intelligence and National Security is designed for a professional audience of researchers and practitioners in industry. This volume is also suitable for graduate-level students in computer science.
Neglected tropical diseases and phytochemicals in drug discovery
Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.
Natural Products Targeting Clinically Relevant Enzymes
Covers the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural product experiments in drug discovery
Explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.
Natural occurrence and biological activities of quinoline derivatives
Provides a comprehensive overview of quinoline derivatives, focusing on their chemical structure, biological activities, and therapeutic benefits. It delves into the natural sources of these derivatives, covering their isolation, characterization, and potential therapeutic applications, particularly in areas such as anti-cancer, anti-inflammatory, antimicrobial, and antimalarial activity. With its emphasis on providing valuable reference material, this book is an indispensable resource for researchers, educators, and professionals in the fields of chemistry, biology, pharmacology, and drug discovery.
Natural language and information systems ; 13th International Conference on Applications of Natural Language to Information Systems, NLDB 2008 London, UK, June 24-27, 2008 Proceedings
This volume contains the papers presented at NLDB 2008, the 13th Inter- tional Conference on Natural Language and Information Systems, held June 25-27,2008.It also containssome of the best researchproposalsas submitted to the NLDB2008 doctoral symposium heldonJune24,2008.Theprogrammealso includes three invited talks covering the main perspectives of the application of naturallanguageto informationsystems: the wayhumansprocess, communicate and understand natural language, what are the implications and challenges - wardssemanticsearchfor the new Webgeneration, how naturallanguageapplies to the well-established database way of querying as a means to unlock data and information for end users.
