الصفحة 1
الصفحة 1
Nonunion of the Long Bones : Diagnosis and treatment with compression-distraction techniques
The primary purpose of this book is to discuss currently available tools for diagnosing long bone nonunions, to illustrate the means of prevention, and to specify the indications for management using compression-distraction techniques.
New and Evolving Infections of the 21st Century
This new volume of the Emerging Infectious Diseases of the 21st Century Series, has complied a collection of chapters by leading authorities of the world on emerging & evolving infections that is a must read for anyone interested in this topic. The chapters by reknown experts have provided a wealth of up-date information, such as clinical spectrum of disease, epidemiology, pathogenesis, diagnosis, management, prevention and future research.
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural Oral Care in Dental Therapy
Because of increasing antibiotic resistance, stronger antibiotics are reserved for serious active infection, paving the way for a greater use of herbal antibiotics. This book helps dentists in implementing safe and effective natural medicine therapies to complement the current practice guidelines. Oral diseases continue to be a major health problem world-wide. Oral health is integral to general well-being and relates to the quality-of-life that extends beyond the functions of the craniofacial complex. The standard Western medicine has had only limited success in the prevention of periodontal disease and in the treatment of a variety of oral diseases.
Medical biotechnology, biopharmaceutics, forensic : science and bioinformatics
Covers a range of topics on exploiting Nigeria’s mega biodiversity for food security and health; DNA forensic science and its applications; medical biotechnology and biopharmaceutics; medicinal and underutilized plants; impact and mitigation of antibiotic resistance; bioinformatics applications; medical insect biotechnology; etc. The book will be useful reference material for the scientists and researchers working in the fields of nutraceuticals, molecular diagnostics and DNA forensics, biopharmaceuticals and medical biotechnology, nanotechnology, antimicrobials from indigenous plant species, bioinformatics, etc.
Infection Control in the Intensive Care Unit
Infection Control in the Intensive Care Unit has been entirely rewritten in this second edition. All statements are justified by the best available evidence, avoiding unsubstantiated expert opinion. The book contains a new section dedicated to the microbiology of the critically ill, specifically, how to process and interpret surveillance cultures to distinguish the ‘normal’ from the ‘abnormal’ carrier state. There are five totally new chapters dealing with evidence-based infection control molecular techniques for outbreak analysis; clinical virology in neonatal, paediatric and adult intensive care; the six basic principles of the therapy of an infection; and the role of the pharmacist in infection control. Attention is given to special topics such as nutrition, gut mucosal protection and the control of antimicrobial resistance. The addition of enteral to parenteral antimicrobials contributes to the control of multi-resistant micro-organisms. This completely revised second edition is a ‘must have’ for anyone requiring in depth knowledge in the ever expanding field of infection control.
Infection and Local Treatment in Orthopedic Surgery
The management of orthopedic infection is an area of growing importance in orthopedic surgery. This text provides a complete overview from basic research to clinical application and future perspectives in the treatment of orthopedic infection emphasising the role of local therapy. The unprecedented collection of experiences of the major experts in the field supplies the reader with long-awaited guidelines for treatment. Covering the various approaches to the treatment of orthopedic infections.
Immune Mechanisms in Inflammatory Bowel Disease
Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.
Hugo and Russell's pharmaceutical microbiology
Microbiology is one of the essential pharmaceutical sciences upon which the study and practice of pharmacy is built. It has a bearing on all aspects of the manufacture of medicines and sterile products, from their design and development to their delivery as quality products. Few interventions are more central to modern medicine than the treatment of infection, where antibiosis, vaccination and hygienic practices have essential roles to play. The COVID-19 pandemic, the appearance of new pathogens and the rise of antibiotic resistance have demonstrated most completely the need for pharmaceutical practitioners, researchers and industrial scientists to be fully conversant with this field. The 9th edition of Hugo and Russell’s Pharmaceutical Microbiology has been updated to meet this need. Having long served as the sole comprehensive textbook covering this subject, it has now been adapted to a critical new period in the advancement of medical and pharmaceutical research and development. Its experienced editors have incorporated contributions from subject experts and created a text which will serve the next generation of pharmacy students, pharmaceutical industry scientists and researchers.
Hot Topics in Infection and Immunity in Children IV
Hot Topics in Infection and Immunity in Children IV contains chapters based on lectures given by speakers at the “Infection and Immunity in Children” course, held in June 2006 at Keble College, Oxford. It was the fourth annual course of this name and this is the fourth book in the series as well. Together the courses and books have become important components of the training available to paediatricians with an interest in this specialty and have become increasingly popular each year. This book covers topics in infectious diseases in children and is intended for Pediatric Infectious Disease trainees, trainers, and all those who manage children with infections.
Hot Topics in Infection and Immunity in Children III
This book is based on the course “Infection and Immunity in Children 2005” which was held at St Catherine’s College Oxford, UK in June 2005. This is the third book in this series covering topics in infection and immunity during childhood and based on the Oxford courses. These courses, and their companion books, are aimed at encouraging excellence in clinical practice and raising the pro? le of paediatric infectious disease with a particular eye on the needs of trainees in the specialty. At the time of writing a fourth course is already at an advanced stage of planning for June 2006 with a completely new programme once again. You will ? nd in this book a wealth of state of the art information about various aspects of paediatric infectious diseases written by leading authorities in the ? eld. We hope this volume will bring new insights into the management of children with infectious diseases and improve the health of children.
Heterocyclic Antitumor Antibiotics
Heterocyclic Compounds Includes aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents. Pathways involving destruction of heterocyclic ring will also be dealt with so that synthesis of specifically functionalized non-heterocyclic molecules can be designed. Overall scope is to cover topics dealing with most of the areas of current trends in heterocyclic chemistry which will suit to a larger heterocyclic community.
Herbal antibiotics : Natural alternatives for treating drug-resistant bacteria ; 2nd ed.
Health care providers have discovered many new resistant strains of bacteria, researchers have added to the growing body of knowledge about herbs, and the need for antivirals to treat emerging infections like SARS and West Nile Encephalitis has become urgent. Within ten years, according to sources cited in the book, pharmaceutical antibiotics will begin to fail at epidemic rates. There are, in fact, no new antibiotics currently in planning or development at any of the major pharmaceutical companies. Most notably, there is none for Gram-negative bacteria, which are emerging as the most dangerous pathogens.
GI Microbiota and Regulation of the Immune System
This book opens with two general reference chapters, which provide an over-view of current knowledge of gastrointestinal immunology and the commensal microbiology of the gut. Next are two chapters dedicated to current methodologies used to investigate the icrobiota and host: molecular analysis of microbial diver-sity and gnotobiotic research. Both positive and negative interactions between the microbiota and the immune system can take place in the gut, with chapters dedicated to probiotics and intestinal diseases associated with unhealthy rnicrobiota.
Gentamicin : Biosynthesis, medicinal applications and potential side effects
Discusses the biosynthesis, medicinal applications and potential side effects of Gentamicin. Topics include Gentamicin used in combination therapy and applied to medicinal materials for clinical applications; use of natural products to enhance the antibiotic activity of Gentamicin and other aminoglycosides; regiospecific Gentamicin functionalization; Gentamicin and particle engineering; and the indications and adverse effects of Gentamicin.
Garlic Extract : Interaction with mechanisms of bacterial resistance
Garlic (Allium sativum) is a medicinal plant which has a diverse biological activities including antioxidant activity, antimicrobial activity, anticancer activity and others… In this article we are focusing on its antimicrobial effect which had been tested individually and in combination with two resisted antibiotics (Ampicillin, Ciprofloxacin) on 3 gram negative bacteria (Proteus mirabilis, klebsiella pneumoniae and Enterobacter aerogenes) to estimate the effect of garlic extract on the activity of the resisted drugs and bacterial resistance mechanism.
Foodborne Diseases
In Foodborne Diseases, leading authorities present a broad overview of the microbial pathogens and toxins associated with foodborne illness while discussing pathogenicity, clinical epidemiology, diagnosis, and treatment. The chapters of this volume cover a wide variety of bacterial pathogens, viruses, protozoans, and parasites, as well as microbial toxins, and also address alternatives to antibiotics, risk assessment, irradiation and other sanitation procedures, and molecular techniques for detecting foodborne pathogens. Additionally, the acclaimed authors discuss pathogen control strategies and look toward future innovations in food safety technology. Covering essential foodborne pathogens, assessment and treatment, Foodborne Diseases is an essential reference for infectious disease specialists, microbiologists, and industrial and research-based scientists in food safety.
Focus on bacterial biofilms
Bacterial biofilms are colonies of bacterial cells embedded in their self-produced matrix composed of polysaccharides, DNA, and proteins. They protect bacterial cells against antibiotics, antibacterial agents, soaps and detergents, and shear stress. Some of the most common biofilm-associated infections in humans include urinary tract infections, infection of wounds and surgical sites, diabetic foot ulcers, dental caries (tooth decay) and gingivitis (gum inflammation), ventilator-associated infections, sinusitis, microbial keratitis, secondary infection related to Covid-19 and other viral infections, and so on. Bacterial resistance to common antibiotics (e.g., penicillin, gentamycin, erythromycin, ciprofloxacin, etc.) is driving us to a catastrophic failure of our health systems. Strategies to develop novel antibacterial agents and technology must be prioritized to combat and eradicate biofilms and their associated challenges. This book provides a comprehensive overview of biofilms with chapters on bacterial virulence factors, quorum sensing in bacteria, antimicrobial resistance in bacteria, strategies to develop new antibacterial agents, and much more.
Essentials of Pharmacology for Dentistry
Pharmacology, the science of drugs (medicines), is a highly dynamic discipline with concepts and priority drugs changing rapidly. Its relevance to all health professionals (including dentists) cannot be over emphasized. Practice of dentistry utilizes drugs both as primary treatment modality, as well as facilitator of/adjuvant to dental procedures. Dentists routinely prescribe analgesics and antibiotics, apply antiseptics and other locally acting drugs, and inject local anaesthetics. Further, many dental patients could be receiving other medication that may have orodental implications or may interact with drugs prescribed by the dentist. Occasionally, dentists have to manage a medical emergency which may arise during a dental procedure or in their clinic. As such, a broad knowledge of pharmacology along with focus on aspects is needed by the dentist.
Essential Practice Guidelines in Primary Care
This book is an excellent summary of the most important evidence-based, nationally recognized, clinical guidelines, with aim to improve the quality of medical care. It represents understandable, useful, easy to implement, one source for questions arises that is best answered by an existing clinical guideline. Together with electronic (PDA) version, should facilitate the implementation of nationally recognized clinical guidelines by primary care physicians.
