الصفحة 7
الصفحة 7
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural product experiments in drug discovery
Explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.
Natural poisons and venoms: Plant toxins : Polyketides, phenylpropanoids and further compounds
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venoms : Animal toxins
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venom : Plant toxins : Terpenes and steroids
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural occurrence and biological activities of quinoline derivatives
Provides a comprehensive overview of quinoline derivatives, focusing on their chemical structure, biological activities, and therapeutic benefits. It delves into the natural sources of these derivatives, covering their isolation, characterization, and potential therapeutic applications, particularly in areas such as anti-cancer, anti-inflammatory, antimicrobial, and antimalarial activity. With its emphasis on providing valuable reference material, this book is an indispensable resource for researchers, educators, and professionals in the fields of chemistry, biology, pharmacology, and drug discovery.
Natural Language Processing – IJCNLP 2004 ; 1st International Joint Conference, Hainan Island, China, March 22-24, 2004, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the First International Joint Conference on Natural Language Processing, IJCNLP 2004, held in Hainan Island, China in March 2004. The 84 revised full papers presented in this volume were carefully selected during two rounds of reviewing and improvement from 211 papers submitted. The papers are organized in topical sections on dialogue and discourse; FSA and parsing algorithms; information extractions and question answering; information retrieval; lexical semantics, ontologies, and linguistic resources; machine translation and multilinguality; NLP software and applications, semantic disambiguities; statistical models and machine learning; taggers, chunkers, and shallow parsers; text and sentence generation; text mining; theories and formalisms for morphology, syntax, and semantics; word segmentation; NLP in mobile information retrieval and user interfaces; and text mining in bioinformatics.
NATO and terrorism catastrophic terrorism and first responders : Threats and mitigation
In this important new book a group of experts represents the current knowledge on the various terrorism threats to first responders resulting from the novel use of conventional weapons, as well radiological, nuclear, biological and chemical weapons. Also, the current situation in selected countries of different sizes and practical experience with terrorism countermeasures (Austria, Israel, Slovenia, Russia, U.S.) is reviewed, focusing on the national operational logistics and the individual needs for improving the present situation. Finally, this book offers innovative solutions to strengthen the level of protection of the first responders, culminating in fifty-one practically applicable recommendations
Nato And Terrorism : On Scene : New Challenges for First Responders and Civil Protection
This book provides information about how leading agencies across the NATO membership are preparing to confront and respond to terrorists deploying Weapons of Mass Destruction (WMD), Weapons of Mass Killing (WMK) and Weapons of Mass Disruption (WMDi). Based on contributions by experts from NATO member states, Israel and the Russian Federation, this book offers information on fourth generation warfare as a new challenge to first responders. It also provides a variety of insights into methods for preparing for and responding to WMD-, WMK-, and WMDi-events, using new technologies and strategies. Furthermore, the book offers solution for restoring the community to functioning after such a major terror attack. Topics include preparing, planning, operations, equipment, training and unique applications of existing technologies for countering terrorist attacks against cities and their infrastructure.
National Tax Policy in Europe : To Be or Not to Be?
The book is dedicated to the question of how much room for national tax policy Member States of the European Union will find necessary and possible to maintain in the future. It focuses on the possibilities Member States have and the constraints they face, such as the need to enhance competitiveness and attractiveness to inward foreign direct investment, to finance social programmes and the limitations imposed by European and International Law. The research question is looked at from economic as well as from legal points of view. This comprehensive approach and the answers given will be of interest to scholars and policy makers alike and may guide the path for future tax developments in Europe.
NASAs Scientist-Astronauts
Mounting pressure in the early 1960s from the National Academy of Sciences (NAS) to study ways of expanding the role of astronauts to conduct science on future space missions led to NASA’s conclusion that flying scientifically trained crewmembers would generate greater returns from each mission. NASA and industry studies continued investigating possibilities that could lead to the eventual creation of the first space stations using surplus Apollo hardware, through the Apollo Applications Programme (AAP).
Nanopharmaceuticals ; Vol.1 : Expectations and realities of multifunctional drug delivery systems
Reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.
Nanoformulations in Human Health: Challenges and Approaches
This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
Mysteries of the Rectangle : Essays on painting
In Mysteries of the Rectangle, Hustvedt concentrates her narrative gifts on the works of such masters as Francisco Goya, Jan Vermeer, Jean-Baptiste-Siméon Chardin, Gerhard Richter, and Joan Mitchell. Through her own personal experiences, Hustvedt is able to reveal things until now hidden in plain sight: an egglike detail in Vermeer's Woman with a Pearl Necklace and the many hidden self-portraits in Goya's series of drawings, Los Caprichos, as well as in his infamous painting The Third of May. Most importantly, these essays exhibit the passion, thrill, and sheer pleasure of bewilderment a work of art can produce—if you simply take the time to look.
Mysteries of English Grammar : A Guide to complexities of the English Language
Despite a history of hundreds of years of research analysing aspects of English grammar, there are still open problems which continue to baffle language researchers today. Such ‘grammar mysteries’ arise for a number of reasons: because the language is changing; because different speakers of the language adhere to distinct norms and thus introduce and maintain variation in the system; because there are differences between the grammar of spoken and written English.
My Heavens : The Adventures of a Lonely Stargazer Building an Over-the-Top Observatory
Whether you might want to undertake building an over-the-top dome observatory yourself or not, you are sure to enjoy this informative tale by Gordon Rogers, told with humor and humility, of his torturous but ultimately rewarding experience with building for himself, attached to his own home, a fancy and sophisticated dome observatory, just for the pleasure of sky watching on beautiful nights (of which there are far too few in England!). Read about all the thinking and planning that went into this venture, and the options considered and rejected. Read about the choices and mistakes made along the way. Finally, read and discover the joys of sky watching using state-of-the-art equipment, and share in the author’s frustrations and triumphs as he completed this project of a lifetime.
Mute people aiding application
Communication is an essential tool for human survival. It is a fundamental and effective method of sharing thoughts, needs, feelings, and opinions. However, a large portion of the world's population lacks the ability to communicate with others. Such as the ones suffering from hearing loss, speech disability, or even both. Those disabilities have a significant impact on their lives in terms of work and relationships. The majority of these people are sometimes unable to support themselves financially due to the lack of job opportunities. Given these difficulties, we have decided to develop an application to help them overcome the obstacles they may encounter in their daily lives. After consulting with two deaf and mute people we customized an application that works in two ways. One of which is to translate their sign language in real time by using mobile camera and recognizing hand motion. The other works by converting text-to-voice, and accurately expressing the user’s emotions with the help of the facial emotion recognition.
Mutagenic Impurities : Strategies for Identification and Control
In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective.
Musculoskeletal Diseases 2021-2024 : Diagnostic Imaging
This book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included.
Musculoskeletal Diseases : Diagnostic Imaging and Interventional Techniques
Written by internationally renowned experts, this volume is a collection of chapters dealing with imaging diagnosis and interventional therapies in musculoskeletal diseases. The different topics are disease-oriented and encompass all the relevant imaging modalities including X-ray technology, nuclear medicine, ultrasound and magnetic resonance, as well as image-guided interventional techniques. This book represents a condensed version of twenty topics relevant in musculoskeletal disease, and is aimed both at residents in radiology and at experienced radiologists wishing to be updated on the current state-of-the art.
