الصفحة 5
الصفحة 5
Insights into Receptor Function and New Drug Development Targets
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function. The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.
Innovative trends in international business and sustainable management
Describes multidimensional trends, challenges, and opportunities for the development of international business and sustainable management in the context of a global pandemic. This book uniquely highlights new priorities of scientific and practical research in the field of international business and sustainable management that require a systematic knowledge of the ongoing transformations of trends, challenges, and opportunities for the development.
Innovative Endocrinology of Cancer
Deals with developments in such topics as mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and hormonal sensitivity of the latter, genesis, dichotomy and endocrinology of cancer in females, and pharmacogenomics and proteomics in oncoendocrinology.
Innovative comparative methods for policy analysis : Beyond the quantitative-qualitative divide
Innovative Comparative Methods for Policy Analysis aims to provide a decisive push to the further development and application of innovative and specific comparative methods for the improvement of policy analysis. To take on this challenge, this volume brings together methodologists and specialists from a broad range of social scientific disciplines and policy fields.
Innovations in Macroeconomics ; 2nd ed.
Modern macroeconomics suffers from an unclear link between short-term Keynesian analysis and long-term growth modelling. Moreover, product and process innovations have been only partially integrated. The analysis suggests new approaches to innovations in open economies in many ways, including the Schumpeterian Mundell-Fleming model and new monetary growth models. A specific focus is on the role of innovations for output, employment and exchange rate developments. A new link between monetary analysis and growth modelling in open economies is presented. Structural change, innovations and growth are considered from a new perspective. This important new book sets a new direction for macroeconomics. By linking several strands of fundamental economic thinking into a coherent, integrated framework it provides a pathbreaking understanding into the fundamental forces shaping macroeconomic performance.
Innovations in Macroeconomics ; 1st ed.
Modern macroeconomics suffers from an unclear link between short-term Keynesian analysis and long-term growth modelling. Moreover, product and process innovations have been only partially integrated. The analysis suggests new approaches to innovations in open economies in many ways, including the Schumpeterian Mundell-Fleming model and new monetary growth models. A specific focus is on the role of innovations for output, employment and exchange rate developments. This book presents a new link between monetary analysis and growth modelling in open economies. Structural change, innovations and growth are considered from a new perspective. With respect to economic policy - in particular innovation policy - the analysis implies major changes, concerning both EU countries and other leading OECD economies.
Innovation, Industrial Dynamics and Structural Transformation : Schumpeterian Legacies
This book provides an account of work in the Schumpeterian and evolutionary tradition of industrial dynamics and the evolution of industries. It is shown that over time industries evolve and change their structure. In this dynamic process change is affected and sometimes constraint by many factors: knowledge and technologies, the capabilities and incentives of actors, new products and processes, and institutions. All these elements and their relations drive innovative activities and affect economic performance in an industry. Investigations into these complex phenomena show a deep interdependence between empirical work delivering a rich account of regularities and stylized facts in the structure of industries and their change, and theoretical analyses ranging from appreciate theorizing to formal modeling.
Innovation Policy in a Knowledge-Based Economy : Theory and Practice
Why Analyze Innovation Policies From a Knowledge- Based Perspective? It is broadly accepted that we have moved (or are moving) to a knowled- based economy, characterized at least by two main features: that knowl edge is a major factor in economic growth, and innovation processes are systemic by nature. It is not surprising that this change in the economic paradigm requires new analytical foundations for innovation policies. One of the purposes of this book is to make suggestions as to what they should include. Underpinning all the chapters in this book is a conviction of the impor tance of dynamic and systemic approaches to innovation policy. Nelson and Arrow saw innovation and the creation of new knowl edge as the emergence and the diffusion of new information, characterized essentially as a public good. The more recent theoretical literature regarded the rationale for innovation policies as being to provide solutions to "mar ket failures". Today, however, knowledge is seen as multidimensional (tacit vs. codified) and open to interpretation. Acknowledging that the creation, coordination and diffusion of knowledge are dynamic and cumu lative processes, and that innovation processes result from the coordination of distributed knowledge, renders the "market failure" view of innovation policies obsolete. Innovation policies must be systemic and dynamic
Innovation Capacity and the City : The Enabling Role of Design
This book represents one of the key milestones of DESIGNSCAPES: value creation through design-enabled innovation”. The book demonstrates that adopting design allows us to embed innovation within the city so as to arrive at feasible answers to complex global challenges. In this way, innovation can become disruptive, while also sparking a dynamic of gradual change in the “urbanscape” it acts within. To explore this potential, the book puts forward the concept of “design enabled innovation in urban environments” and examines the part that the city can play in promoting and facilitating the adoption of design among public and private sector innovators. This leads to a potential evaluation framework in which a given urbanscape is assessed both in terms of its capacity for generating innovation, and of the nature (more or less design-dependent or design-prone) of the innovative initiatives it hosts. This thread of reasoning holds many promising implications, including a possible “third way” between those who dream of an alternative economic model where revenues and growth are sacrificed on the altar of social and environmental respect, and the supporters of the traditional market-based view, who feel it is enough to add a touch of responsibility and concern to a system that should continue rewarding the profitability of innovations.
Innovation and Firm Performance : An Empirical Investigation for German Firms
The process of firms’ growth – in terms of productivity or employment – is a major concern of policy makers. In this context, innovations are considered to play a crucial role in stimulating firms’ performance. This book investigates this general hypothesis by looking at three topics: 1. Does innovation lead to an increase in employment growth? 2. Does innovation boost labour productivity? 3. Does innovation in one period improve innovation performance in subsequent periods? Based on a comprehensive innovation panel dataset for German firms, this book presents detailed results for each question, in particular by separating the effects induced by new products from those induced by the introduction of new production technologies. From a theoretical point of view, amongst others, a new multi-product model has been developed to study employment effects.
Innate and Adaptive Immunity in the Tumor Microenvironment
Recent studies, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues.
Injecting Salmonella Bacteria in to the Tumor Cures Cancer
The human body is inhabited by millions of tiny living organisms like good bacteria. We acquire these bacteria during birth and the first years of life, and they live with us throughout our lives. The human microbiomes are involved in healthy growth, in protecting the body from invaders, in helping digestion, and in regulating moods, but sometimes these bacteria can also be harmful. We need to take good care of our health to avoid the development of some diseases, like salmonella for example. Salmonella infections in humans can range from self-limiting gastroenteritis typically associated with non-typhoidal Salmonella (NTS) to typhoidal fever, which can be life-threatening. Salmonellosis causes considerable morbidity and mortality in both humans and animals, and has a significant socioeconomic impact worldwide.
Indigenous Knowledge and Education in Africa
This book presents a strong philosophical, theoretical and practical argument for the mainstreaming of indigenous knowledge in curricula development, and in teaching and learning across the African continent. Since the dawn of political independence in Africa, there has been an ongoing search for the kind of education that will create a class of principled and innovative citizens who are sensitive to and committed to the needs of the continent. When indigenous or environment-generated knowledge forms the basis of learning in classrooms, learners are able to immediately connect their education with their lived reality. The result is much introspection, creativity and innovation across fields, sectors and disciplines, leading to societal transformation. Drawing on several theoretical assertions, examples from a wide range of disciplines, and experiences gathered from different continents at different points in history, the book establishes that for education to trigger the necessary transformation in Africa, it should be constructed on a strong foundation of learners’ indigenous knowledge. The book presents a distinct and uncharted pathway for Africa to advance sustainably through home-grown and grassroots based ideas, leading to advances in science and technology, growth of indigenous African business and the transformation of Africans into conscious and active participants in the continent’s progress.
Indian Life and Health Insurance Industry : A Marketing Approach
Due to its massive population, sound economic fundamentals, dynamic improvements in the insurance regulatory framework and an increasing awareness amongst Indians about the relevance of insurances, India offers extensive opportunities for market entry and expansion in the insurance industry. "The book reveals insightful ideas about the Indian insurance industry along with a discussion on the best practices of the marketing mix. Novi's impressive thesis, which forms the basis of this book, prompted me to contribute to her research with an India perspective. I am sure that this book will be an important reference material for emerging markets with similar growth dynamics."
Income Elasticity and Economic Development : Methods and Applications
Income Elasticity and Economic Development: Methods and Applications is mainly concerned with methods of estimating income elasticity. This field is connected with economic development that can be achieved by reducing income inequality. This is highly relevant in today's world, where the gap between rich and poor is widening with the growth of economic development. Income Elasticity and Economic Development: Methods and Applications provides a good example in showing how to calculate income elasticity, using a number of methods from widely available grouped data. Some of the techniques presented here can be used in a wide range of policy areas in all developed, developing and under-developed countries. Policy analysts, economists, business analysts and market researchers will find this book very useful.
In Vitro Culture of Mycorrhizas
biologists have made important progress in understanding better the functioning of AM fungi. An in vitro technique has been developed using mycorrhizal root organ cultures, which made it possible to investigate the genetics, cell biology and physiology of AM fungi. We can now be objective enough to critically evaluate the impacts the in vitro technique has had to improve our knowledge on mycorrhizal symbiosis.
In and Out of Equilibrium 2
The intersection of probability and physics has been a rich and explosive area of growth in the past three decades, specifically covering such subjects as percolation theory, random walks in random environment, disordered systems, interacting particle systems and their many connections to statistical mechanics. The last decade was particularly fruitful for all these topics. This book reflects this development and marks also the first decade of the Brazilian School of Probability. This volume consists of a collection of invited articles, written by some of the most distinguished probabilists, most of whom have been personally responsible for advances in the various subfields of probability.
Improving operating leverage using hyperautomation : Unlock strategic advantages across banking and non-banking financial institutions
Delving in depth into enterprise non-interest operating cost management and operating leverage. operating Leverage is about managing a bank's capabilities and its capacity to deliver its products and services efficiently. it is not limited to managing operational costs but includes the operational support for the growth of business and for improving profitability. the reader can learn to improve risk adjusted operational effectiveness by implementing a nuanced approach to managing performance, risk, control, and cost simultaneously, at the process level. the book explains why hyperautomation, a technology that intelligently automates business processes is a more advanced and comprehensive way to manage these factors in a holistic and integrated way.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Illustrated Pediatric Dentistry ; Part 1
This textbook is modernized with the latest information and techniques in pediatric dentistry. The chapters cover primary pediatric dentistry, its clinical aspects, preventive dentistry, and information about the latest trends in the specialty. The text will equip readers with the knowledge suited to the changing
