الصفحة 3
الصفحة 3
New Partnerships for Innovation in Microfinance
"The book presents valuable information with a strong analytical tilt. … targets economists and managers in banking and development finance organizations, as well as policy makers, international development organizations, and development agencies. Because it covers a range of issues related to funding microfinance, and is written in relatively simple language, yet intelligently argued, it can be used as a resource book for courses on microfinance funding and development. … a useful read for practitioners in the sector."
New Narratives in Eighteenth-Century Chemistry : Contributions from the 1st Francis Bacon Workshop, 21-23 April 2005, California Institute of Technology, Pasadena, California
The eighteenth century has long been considered critical for the development of modern chemistry, yet many crucial features of the period remain largely unknown or unexplored, for general accounts--often built around Lavoisier--have remained quite selective. This volume presents new approaches and topics in an attempt to build a richer, fuller, more complex view of chemical work during the period. Themes include "late-phase" alchemy, professionalization, chemical education, and the links and relations between chemistry and pharmacy, medicine, agriculture, and geology.
New Methodologies and Techniques for a Sustainable Organic Chemistry
Chemical industries have to face the big challenge of finding adequate processes to produce large quantities of new products for which there is a present need, decreasing at the same time both the impact on the environment and the risk of disasters. These issues have led to the establishment of new concepts of sustainable development as affirmed in the Rio Declaration on Environment and Development in the early 90’s and has been the subject of intensive studies in the last two decades. The book addresses this challenge collecting the recent “New Methodologies and Techniques for a Sustainable Organic Chemistry”.
New Frontiers in Polymer Synthesis
It is generally accepted that a new material is often developed by ?nding a new synthesis method of reaction or a new reaction catalyst. Historically, a typical example may be referred to as a Ziegler–Natta catalyst, which has allowed large-scale production of petroleum-based polyole?ns since the middle of the 20th century. New polymer synthesis, therefore, will hopefully lead to creation of new polymer materials in the 21st century. This special issue contributed by three groups focuses on recent advances in polymer synthesis methods, which handle the cutting-edge aspects of the advanced technology.
New Drug Development for Known and Emerging Viruses
This book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic.
New Carbon Based Materials for Electrochemical Energy Storage Systems : Batteries, Supercapacitors and Fuel Cells
This NATO-ARW volume contains a diverse collection of papers addressing the role of carbon in some key electrochemical systems, both conventional and emerging. These papers discuss the latest issues associated with development, synthesis, characterization and use of new advanced carbonaceous materials for electrochemical energy storage. Such systems include: metal-air primary and rechargeable batteries, fuel cells, supercapacitors, cathodes and anodes of lithium-ion and lithium polymer rechargeable batteries, as well as nanocarbon materials of the future.
New Aspects of Zirconium Containing Organic Compounds
Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts. They offer novel synthetic opportunities in carbon-carbon bond formation based on either carbene-centered reactions or on metal-templated processes which makes them indispensable in modern synthetic methodology. The most prominent metal carbenes are now either commercially available or easy to synthesize and handle with modern laboratory techniques. This volume organized in eight chapters written by the leading scientists in the field illustrates the theoretical background, non-classical nucleophilic and cycloaddition patterns, chromium-templated benzannulation and photo-induced reactions, rhodium-catalyzed carbene transfer as well as the principles and applications of olefin metathesis which has coined the progress in synthetic methodology over the past decade. Designed for researchers in academia and industry as well as graduate students it presents the state-of-the-art potential of carbene complexes in modern organic synthesis.
New Aspects in Phosphorus Chemistry V
The use of polyphosphazenes as fluoroelastomers, flame retardants and self-extinguishing macromolecules, polymeric ionic conductors, biomaterials, and photosensitive polymeric compounds is outlined. This volume,as well as the four precedent volumes,describes only in part the huge number of original papers on phosphorus-related topics. Some further volumes will be necessary in the future to cover all aspects of this chemistry in perpetual rebirth.
New Algorithms for Macromolecular Simulation
Molecular simulation is a widely used tool in biology, chemistry, physics and engineering. This book contains a collection of articles by leading researchers who are developing new methods for molecular modelling and simulation. Topics addressed here include: multiscale formulations for biomolecular modelling, such as quantum-classical methods and advanced solvation techniques; protein folding methods and schemes for sampling complex landscapes; membrane simulations; free energy calculation; and techniques for improving ergodicity. The book is meant to be useful for practitioners in the simulation community and for those new to molecular simulation who require a broad introduction to the state of the art.
Neutron Spin Echo in Polymer Systems
Neutron spin echo spectroscopy (NSE) provides the unique opportunity to unravel the molecular dynamics of polymer chains in space and time, covering most of the relevant length and time scales. This article reviews in a comprehensive form recent advances in the application of NSE to problems in polymer physics and describes in terms of examples expected future trends. The review commences with a description of NSE covering both the generic longitudinal field set-up as well as the resonance technique. Then, NSE results for homopolymers chains are presented, covering all length scales from the very local secondary J3-relaxation to large scale reptation. This overview is the core of the review. Thereafter the dynamics of more complex systems is addressed. Starting from polymer blends, diblock copolymers, gels, micelles, stars and dendrirners, rubbery electrolytes and biological macromolecules are discussed. Wherever possible the review relates the NSE findings to the results of other techniques, in particular emphasizing computer simulations.
Neutron and X-ray Spectroscopy
Neutron and X-Ray Spectroscopy delivers an up-to-date account of the principles and practice of inelastic and spectroscopic methods available at neutron and synchrotron sources, including recent developments. The chapters are based on a course of lectures and practicals (the HERCULES course) delivered to young scientists who require these methods in their professional careers. Each chapter, written by a leading specialist in the field, introduces the basic concepts of the technique and provides an overview of recent work. This volume, which focuses on spectroscopic techniques in synchrotron radiation and inelastic neutron scattering, will be a primary source of information for physicists, chemists and materials scientists who wish to acquire a basic understanding of these techniques and to discover the possibilities offered by them. Emphasizing the complementarity of the neutron and X-ray methods, this tutorial will also be invaluable to scientists already working in neighboring fields who seek to extend their knowledge.
Neurochemical Aspects of Excitotoxicity
Leading researchers offer cutting-edge information on glutamate metabolism in the brain, examining the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases.
Neuroacanthocytosis Syndromes
Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.
Neodymium Based Ziegler Catalysts - Fundamental Chemistry
In this volume we try to review the available literature by two independentapproaches to Nd and Ln-catalyzed diene polymerizations. In the first part ofthe volume, which is entitled “Neodymium-Based Ziegler/Natta Catalysts andtheir Application in Diene Polymerization”, a polymer chemist’s view is givenwith strong emphasis on Nd-based catalyst systems. Also technological andindustrial aspects of Nd-catalyzed diene polymerizations are addressed. In thesecond part of the volume, which is entitled “Rare-Earth Metals and AluminumGetting Close in Ziegler-type Organometallics”, a more organometallic per-spective is given and Ln-based catalyst systems are addressed. By the synopsisof these different perspectives, the reader will comprehend the complexity ofLn-based Ziegler catalyst systems and their application to the polymerizationof dienes.
Neglected tropical diseases and phytochemicals in drug discovery
Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.
Natural Products Targeting Clinically Relevant Enzymes
Covers the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural Product Synthesis II : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural Product Synthesis I : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural product experiments in drug discovery
Explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.
