الصفحة 23
الصفحة 23
Insights into Receptor Function and New Drug Development Targets
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function. The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.
Inside asylum bureaucracy : Organizing refugee status determination in Austria
Provides sociological insight into governmental action on the administration of asylum in the European context. It offers an in-depth understanding of how decision-making officials encounter and respond to structural contradictions in the asylum procedure produced by diverging legal, political, and administrative objectives.The study focuses on structural aspects on the one hand, such as legal and organisational elements, and aspects of agency on the other hand, examining the social practices and processes going on at the frontside and the backside of the administrative asylum system.
Insects and Ecosystem Function
In the past two decades, an increasing number of ecologists have started to investigate the importance of biodiversity for ecological processes such as energy flow and nutrient cycling, often referred to as 'ecosystem functioning'. Insects are a dominant component of biodiversity in terrestrial ecosystems and play a key role in mediating the relationship between plants and ecosystem processes. This volume is the first to summarize their effects on ecosystem functioning, focusing mainly, but not exclusively, on herbivorous insects. Renowned authors with extensive experience in the field of plant-insect interactions, contribute to the volume using examples from their own work. In addition to providing concise reviews of the field, this volume discusses in detail the advantages and disadvantages of various techniques of manipulating insect herbivory. Thus, the text provides both a theoretical basis as well as practical advice for future manipulative studies of biodiversity-ecosystem functioning.
Insecticides Design Using Advanced Technologies
Among the highlights of this book are the use of nanotechnology to increase potency of available insecticides, the use of genetic engineering techniques for controlling insect pests, the development of novel insecticides that bind to unique biochemical receptors, the exploration of natural products as a source for environmentally acceptable insecticides, and the use of insect genomics and cell lines for determining biological and biochemical modes of action of new insecticides.
Insect Conservation and Islands
A series of original papers and reviews dealing with the peculiarities of island insects and their conservation in many parts of the world. Contributions to this special issue of Journal of Insect Conservation range from biogeographical analyses andecological features of island insects and their evolution to the variety of concerns for their wellbeing, and practical conservation through a variety of, sometimes novel, approaches. They provide a valuable and up-to-date resource for entomologists and conservation practitioners.
Innovative techniques in instruction technology, e-learning, e-assessment, and education
Innovative Techniques in Instruction Technology, E-Learning, E-Assessment and Education is a collection of world-class paper articles addressing the following topics:E-Learning including development of courses and systems for technical and liberal studies programs; online laboratories; intelligent testing using fuzzy logic; evaluation of on line courses in comparison to traditional courses; mediation in virtual environments; and methods for speaker verification.
Innovative Medicine : Basic Research and Development
Devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”.
Innovations Towards Sustainability : Conditions and Consequences
The volume contains eight articles together with comments by twenty authors and discussants on the topic of innovations and sustainability. It provides a competently written, balanced and differentiated state-of-the-art insight into the relation between innovations and sustainability from the perspective of evolutionary economics. The scope of the contributions encompasses the technological, social, organizational, and political dimensions of the topic. Each article is discussed by a competently written commentary providing a critical evaluation and relating it to the relevant literature. Particular interest lies on the issues of steering opportunities and path formation capabilities by decentralized agents, or governmental institutions from the viewpoint of evolutionary economics.
Innovations in Quantitative Risk Management ; TU München, September 2013
The KPMG Center of Excellence in Risk Management conference Risk Management Reloaded and this proceedings volume contribute to bridging the gap between academia –providing methodological advances– and practice –having a firm understanding of the economic conditions in which a given model is used. Discussed fields of application range from asset management, credit risk, and energy to risk management issues in insurance. Methodologically, dependence modeling, multiple-curve interest rate-models, and model risk are addressed. Finally, regulatory developments and possible limits of mathematical modeling are discussed.
Innovations in preventive dentistry
Preventive dentistry is a constantly changing and developing field: As new research emerges, some practices that had once been revolutionary are abandoned, while others continue to withstand the test of time. This book discusses new developments and innovations in preventive dentistry, from primary prevention to secondary prevention by inactivating initial lesions, and on to tertiary prevention to avoid subsequent progression and complications of manifest oral disease. The book relies on a solid evidence base and instructs readers how this can be translated into clinical dental practice—what changes should be made to how we practice and why they should be made. Topics include caries and periodontal disease, orthodontic problems, diagnostic approaches, diet and oral health, oral hygiene, oral disease patterns, caries treatment, fluoride guidelines, risk management, sealants, and probiotics.
Innovations in Machine Learning : Theory and Applications
Machine learning is currently one of the most rapidly growing areas of research in computer science. In compiling this volume we have brought together contributions from some of the most prestigious researchers in this field. This book covers the three main learning systems; symbolic learning, neural networks and genetic algorithms as well as providing a tutorial on learning casual influences. Each of the nine chapters is self-contained. Both theoreticians and application scientists/engineers in the broad area of artificial intelligence will find this volume valuable. It also provides a useful sourcebook for Postgraduate since it shows the direction of current research.
Innovations in E-learning, Instruction Technology, Assessment and Engineering Education
Innovations in E-learning, Instruction Technology, Assessment and Engineering Education is a collection of world class paper articles addressing the following topics: E-Learning including development of courses and systems for technical and liberal studies programs; online laboratories; intelligent testing using fuzzy logic; evaluation of on line courses in comparison to traditional courses; mediation in virtual environments; and methods for speaker verification. Instruction Technology including internet textbooks; pedagogy-oriented markup languages; graphic design possibilities; open source classroom management software; automatic email response systems; tablet-pcs; personalization using web mining technology; intelligent digital chalkboards; virtual room concepts for cooperative scientific work; and network technologies, management, and architecture.
Innovations in classification, data science, and information systems ; Proceedings of the 27th Annual Conference of the Gesellschaft für Klassifikation e.V., Brandenburg University of Technology, Cottbus, March 12-14, 2003
The volume presents innovations in data analysis and classification and gives an overview of the state of the art in these scientific fields and applications. Areas that receive considerable attention in the book are discrimination and clustering, data analysis and statistics, as well as applications in marketing, finance, and medicine. The reader will find material on recent technical and methodological developments and a large number of applications demonstrating the usefulness of the newly developed techniques.
Innovations in Applied Artificial Intelligence ; 18th International Conference on Industrial and Engineering Applications of Artificial Intelligence and Expert Systems, IEA/AIE 2005, Bari, Italy, June 22-24, 2005, Proceedings
The contributions oriented to the technological aspects of AI and the quality of the papers are witness to a research activity clearly aimed at consolidating the theoretical results that have already been achieved. The c- ference program also included two invited lectures, by Katharina Morik and Roberto Pieraccini. Many people contributed in different ways to the success of the conference and to this volume. The authors who continue to show their enthusiastic interest in applied intelligence research are a very important part of our success. We highly appreciate the contribution of the members of the Program Committee, as well as others who reviewed all the submitted papers with eficiency and dedication.
Innovations for requirement analysis : From stakeholders needs to formal designs ; 14th Monterey Workshop 2007, Monterey, CA, USA, September 10-13, 2007. Revised Selected Papers
This book presents the thoroughly refereed and revised proceedings of the 14th Monterey workshop, held in Monterey, CA, USA, September 10-13, 2007. The theme of the workshop was Innovations for Requirement Analysis: From Stakeholders' Needs to Formal Designs.The 10 revised full papers included in the book were carefully selected during two rounds of reviewing and revision. These are preceded by the abstracts of the three keynote talks as well as a detailed introduction to the theme of the workshop, including a case study used by many participants to frame their analyses, and a summary of the workshop's results.
Innovation, Networks, and Knowledge Spillovers : Selected Essays
The volume is in three parts. The first part demonstrates that the processes of innovation and technological change are spatially differentiated, both regionally within countries and internationally between countries. The second part broadens, both conceptually and empirically, our understanding of the innovation process and the process of network formation, by examining the increasing importance of knowledge creation and diffusion in the new economy and how this is changing the nature of firms in crucial ways. Particular focus is laid on identifying the growing pressures for firms to develop more inter- and intrafirm networks and on providing lucid illustrations of these different kinds of networks. The third part discusses key issues related to the systems of innovation approach as a conceptual framework for regional innovation analysis and directs attention to enlightening conceptual and empirical work on the issue how knowledge spills over locally.
Innovation Management
Not solely covering new products, Innovation Management focuses on new services and new business models; in doing so, it provides an introduction to new business development. The book follows the logic of the innovation process, from idea development via selection to implementation, and discusses these topics both on the level of the company and individual projects. Its content is evidence-based, but with many practical examples.
Innovation in Life Cycle Engineering and Sustainable Development
Business models, which aims at determining how efficient can be a life cycle strategy from different point of view (customer, policy, environment, economics,…). End of life strategies, presenting recent approaches and technological solutions for end-of life treatments. Product development for sustainability, which aims at showing how designers integrate environmental conside- tions to improve their solutions. Product life cycle management, dealing with methods and tools to support life cycle considerations.
Innovation Economics, Engineering and Management Handbook 2 : Special Themes
Innovation Economics, Engineering and Management Handbook 2 is the second of the two volumes that comprise this book. The main objectives across both volumes are to study the innovation processes in todays information and knowledge society; to analyze how links between research and business have intensified; and to discuss the methods by which innovation emerges and is managed by firms, not only from a local perspective but also a global one.
Innovation Economics, Engineering and Management Handbook 1 : Main Themes
Innovation Economics, Engineering and Management Handbook 1 is the first of the two volumes that comprise this book. The main objectives across both volumes are to study the innovation processes in todays information and knowledge society; to analyze how links between research and business have intensified; and to discuss the methods by which innovation emerges and is managed by firms, not only from a local perspective but also a global one.
