الصفحة 23
الصفحة 23
Cancer du sein avancé : 29es Journées de la Société Française de Sénologie et Pathologie Mammaire (SFSPM) Avignon, 14–16 novembre 2007 = Advanced breast cancer : 29th Days of the French Society of Senology and Breast Pathology (SFSPM) Avignon, November 14–16, 2007
These days are an opportunity to remind and persuade those less convinced that the treatment of this very particular phase of the disease is not limited to a score played by a few speakers or even by medical oncologists alone; but on the contrary, we must bring into play a truly philharmonic polyphonic ensemble, united around the patient and comprising all the players in multidisciplinary care: general practitioner, surgeon, radiotherapist, imaging specialist, gynecologist, general practitioner, psychologist, algologist, supportive care workers ...
Cancer du sein ; Compte rendu du cours supérieur francophone de cancérologie (Saint-Paul-de-V Vence, ence, 18–20 janvier 2007) = Breast cancer : Proceedings of the French-speaking oncology higher course (Saint-Paul-de-V Vence, ence, 18–20 January 2007)
Durant les deux premières journées, toutes les étapes importantes de la prise en charge des cancers du sein ont été déclinées. L’analyse du risque de voir survenir un cancer du sein a été explorée dans sa diversité suivie par les résultats du dépistage organisé et les problèmes du diagnostic. Les traitements locorégionaux ont précédé les traitements adjuvants sans oublier les patientes dont la tumeur présentait une hyperexpression de HER2. Une session a été consacrée aux cancers métastatiques et une autre aux personnes âgées. Comme à chaque cours, nous nous sommes penchés sur l’avenir en dissertant sur la classification moléculaire et sur le passé avec la très belle conférence du Pr David Khayat sur le bilan du Plan Cancer.
Cancer du sein ; Compte rendu cours supérieur francophone de cancérologie, (Saint-Paul-de-Vence 13-15 Janvier 2005) = Breast cancer ; Report on the advanced French-language course in oncology, (Saint-Paul-de-Vence, January 13-15, 2005)
In January 2005, the 9th Cours de Saint-Paul-de-Vence, devoted to Breast Cancer, was dominated by the establishment of "Recommendations for Clinical Practice". The five subjects of these recommendations, such as the management of the axillary cavity, neo-adjuvant treatments, the management of patients whose tumor overexpresses HER2, adjuvant hormone therapy and finally adjuvant chemotherapy have been widely discussed. As in each course, certain essential fields were treated such as organized screening, conventional radiology and MRI, prognostic and predictive factors. Ductal cancers and lobular cancers have been compared in a remarkable way in three papers which were produced by the Saint-Cloud school. Data on in situ cancers have been updated. Finally, advice was given for the use of the various standards, whether local, regional or national.R2, l¹hormonothérapie adjuvante et enfin la chimiothérapie adjuvante ont été largement abordés.
Cancer cell biology : methods and protocols
Provides detailed methods on the mechanisms of underlying cancer cell biology. Chapters guide readers through techniques for culturing cancer cell lines, xenografts, cryopreservation of tumor cells, analyzing the co-culture of breast cancer cells, protein secretion by ELISA, flow cytometry-based, multi-parametric immunofluorescence analysis, protein expression by western blot, analysis of surface protein levels, protein recycling by biotinylation assay, and proteomics analysis by liquid chromatography-mass spectrometry.
Cancer
The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Cadmium toxicity : challenges and solutions
Offers a comprehensive collection of review and case chapters that cover cadmium toxicity and remediation. It covers sources of cadmium contamination, its impact on human health, and prospective remediation strategies, taking a multi-disciplinary approach a focus on application of recent advanced biological technology. The chapters here bring together a diverse group of environmental science, sustainability and health researchers to address the challenges caused by cadmium contamination, explaining the routes of exposure to environmental cadmium, how cadmium is transported in ecosystems, and the health risks linked to cadmium exposure in food and the environment.
CADD and informatics in drug discovery
Updates knowledge on recent advances in computational and bioinformatics tools/techniques and their practical applications in modern drug design and discovery programme. Also it encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas / presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, RandD personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, De-novo drug design, Pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and system biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to different stakeholders working in the pharmaceutical and biotechnology industries (RandD), the academic as well as research sectors. .
Business modeling and software design ; 10th International Symposium, BMSD 2020, Berlin, Germany, July 6-8, 2020, Proceedings
This book constitutes the refereed proceedings of the 10th International Symposium on Business Modeling and Software Design, BMSD 2020, which took place in Berlin, Germany, in July 2020. BMSD is a leading international forum that brings together researchers and practitioners interested in business modeling and its relation to software design. Particular areas of interest are: Business Processes and Enterprise Engineering; Business Models and Requirements; Business Models and Services; Business Models and Software; Information Systems Architectures and Paradigms; Data Aspects in Business Modeling and Software Development; Blockchain-Based Business Models and Information Systems; IoT and Implications for Enterprise Information Systems.
Bridging laboratory and field research for genetic control of disease vectors
Contemporary research on genetic control of disease-transmitting insects knows two kinds of scientists: those that work in the laboratory and those known as ‘field people’. Over the last decade, both groups seem to have developed differing research priorities, address fundamentally different aspects within the overall discipline of infectious-disease control, and worse, have developed a scientific ‘language’ that is no longer understood by the ‘other’ party. This gap widens every day, between the North and the South, between ecologists and molecular biologists, geneticists and behaviourists, etc. The need to develop a common research agenda that bridges this gap has been identified as a top priority by all parties involved. Only then shall the goal of developing appropriate genetic-control strategies for vectors of disease become reality.
Bridging divides : Maritime canals as invasion corridors
Maritime canals dissolve natural barriers to the dispersal of marine organisms, thus providing novel opportunities for natural dispersal, as well as for shipping-mediated transport. The introduction of alien species has proved to be one of the most profound and damaging of anthropogenic deeds - with both ecological and economic costs. This book is the first to assess the impacts of the world’s three principal maritime canals – the Kiel, the Panama, the Suez – as invasion corridors for alien biota. These three canals differ in their hydrological regimes, the types of biotas they connect, and in their permeability to invasions.
Breast cancer research and treatment : innovative concepts
Focuses on innovative treatment options for breast cancer, including surgery, radiotherapy, systemic therapy and of course immunotherapy that is changing outcomes in some aggressive breast cancer histotypes. Subsequent chapters also address the ongoing emerging research in the screening, diagnostics, and management of all subtypes of breast cancers. All current landscapes and future perspectives in each molecular subtype: luminal, HER2-positive, and triple-negative breast cancers are discussed within the different chapters. Breast cancer is still the most common cancer and cause of cancer deaths among women worldwide. The improvement of breast cancer outcome appears to be strictly related to the validation of precise biomarkers that enable us to better select personalized approaches in breast cancer management. The closing chapters deal with the challenges of low income countries of conducting research in the era of precision medicine for cancer. The book is edited and authored by leading experts in this field and will be of interest for clinicians and scientists alike
Brand hate : Navigating consumer negativity in the digital world, 2nd
Focuses on the concept of “brand hate” and consumer negativity in today’s digital markets. It explores the emotional detachment consumers generate against valued brands and how negative experiences affect their and other consumers' loyalty. The book defines consumer brand hate and discusses its dimensions, antecedents, and consequences as well as the semiotics and legality of such brand hate activities based on current brand dilution arguments. It describes the situations which lead to anti-branding and how consumers choose to express their dissatisfaction with a company on individual and social levels. This newly updated edition discusses recent research findings from brand hate literature with new cases and extended managerial analysis.
Brain-computer interfaces : An international sssessment of research and development trends
This WTEC study gathered information on worldwide status and trends in BCI research to disseminate to government decisionmakers and the research community. The study reviewed and assessed the state of the art in sensor technology, the biotic-abiotic interface and biocompatibility, data analysis and modeling, hardware implementation, systems engineering, functional electrical stimulation, noninvasive communication systems, and cognitive and emotional neuroprostheses in academic research and industry.
Brain and Human Body Modeling 2020 : Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting
This book describes modern applications of computational human modeling in an effort to advance neurology, cancer treatment, and radio-frequency studies including regulatory, safety, and wireless communication fields.
Bone Morphogenetic Proteins : From Local to Systemic Therapeutics
Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.
Blockchains For Network Security : Principles, technologies and applications
Blockchain technology is a powerful, cost-effective method for network security. Essentially, it is a decentralized ledger for storing all committed transactions in trustless environments by integrating several core technologies such as cryptographic hash, digital signature and distributed consensus mechanisms. Over the past few years, blockchain technology has been used in a variety of network interaction systems such as smart contracts, public services, Internet of Things (IoT), social networks, reputation systems and security and financial services. With its widespread adoption, there has been increased focus on utilizing blockchain technologies to address network security concerns and vulnerabilities as well as understanding real-world security implications.
Blockchain, artificial intelligence, and the internet of things : Possibilities and opportunities
Provides basic concepts and deep knowledge about various security mechanisms that can be implemented in IoT through Blockchain technology. This book aids readers in gaining insight and knowledge about providing security and solutions to different challenges in IoT using Blockchain technology. This book primarily focuses on challenges to addressing the integration of the IoT with Blockchain with respect to potential benefits for IoT. This book gives descriptive analysis of Blockchain integrated with IoT applications and platforms for the development of IoT solutions along with possible topologies to that integration. Several application examples are included in a variety of industries / Provides the latest on secure IIoT communication using Blockchain technology for Industry 4.0 / Includes updates on using Blockchain technology in secure vehicular communication (VANET), healthcare, retail, and gaming / Provides the latest on secure IIoT communication using Blockchain technology for Industry 4.0
Blockchain and crypto currency : Building a high quality marketplace for crypto data
This book contributes to the creation of a cyber ecosystem supported by blockchain technology in which technology and people can coexist in harmony. Blockchains have shown that trusted records, or ledgers, of permanent data can be stored on the Internet in a decentralized manner.
Biotic elicitors: Production, purification, and characterization
Details techniques to study biotic elicitors involved in the field of agriculture for the benefit of the environment and growers. Chapters guide readers through protein, carbohydrate, lipid, glycoprotein and glycolipid components derived from microorganisms and their production, purification, and characterization.
Bioterrorism and Infectious Agents : A New Dilemma for the 21st Century
Since the terrorist attack on the United States on September 11, 2001 and subsequent cases of anthrax in Florida and New York City, attention has been focused on the threat of b- logical warfare and bioterrorism. Biological warfare agents are de?ned as “living org- isms, whatever their nature, or infected material derived from them, which are used for h- tile purposes and intended to cause disease or death in man, animals and plants, and depend for their efforts on the ability to multiply in person, animal or plant attacked.” Biological warfare agents may be well suited for bioterrorism to create havoc and terror in a civilian population, because they are cheap and easy to obtain and dispense. Infectious or contagious diseases have played a major part in the history of warfare – deliberately or inadvertently – in restricting or assisting invading armies over the centuries. In 1346, the Tartars catapulted plaque-infected bodies into Kaffa in the Crimea to end a 3-year siege. Blankets contaminated with smallpox to infect North American Indians were used by British forces in the 18th century. More recently, the Japanese released ?eas infected with plaque in Chinese cities in the 1930s and 1940s. Biological research programs for both offensive and defensive strategies have been developed by the United States, Britain, the former Soviet Union, and Canada; several other nations are thought to have such programs.
