Author

Awad –R.; Zarzour- W.; Kabalan- Y.

Published in

Damascus University Journal of Health Sciences, Volume 22, Issue 1, 2006

Abstract

Cytokines production is associated with diabetes mellitus and in its turn is associated with infiltration of the islets of Langerhans with autoreactive lymphocytes and specific destruction of the insulin-producing B cells. Our aim is therefore to investigate the effect potential role of the effect of the cytokine especially (interleukin-1B, interleukin-6, interleukin-8) and C-reactive protein (C.R.P.) on the microvascular complications of diabetes (nephropathy).

A total of 31 diabetic patients with nephropathy aged 45 to 60 years, undergoing dialysis were compared with non-diabetic control subjects (N=20) after matching for age and sex, and were compared also with diabetic subjects without nephropathy (N=124). Immune parameters were analyzed in serum with rigidly evaluated ELISA.

Serum proinflammatory interleukin-6 (IL-6) and interleukin-8 (IL-8) concentrations were higher in nephropathy diabetic patients than in the control subjects.

(Mean for IL-6 in nephropathy and control subjects 6.9 Pg/ml, 1.2 Pg/ml respectively P≤0.05).

Link to read full paper

http://www.damascusuniversity.edu.sy/mag/health/old/medical/2006/1-2006/Awad.pdf