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Title: The Prevalence of Celiac Disease Among Female University Students,

Damascus-Syria

Authors: Nada Dehneh,

Abstract:

Objective: Celiac disease is a systemic immune-mediated disorder triggered by

gluten ingestion in genetically susceptible individuals. While previous studies

indicate a high prevalence (1.6%) in the Syrian population, data on specific

demographic groups are limited. This study aimed to determine the seroprevalence

of celiac disease among female students at the Arab International University and to

assess its association with haematological manifestations and HLA-DQ genotypes .

Methods: A cross-sectional study was conducted involving 88 female students

with elevated/deficient iron and high /low BMI. Measurements included height and

weight, iron, red blood cells profile including haemoglobin, and serological

screening performed using anti DGP IgA, in addition to low resolution HLA-DQ

genotyping.

Results: Low resolution HLA-DQ2-DQ8 was probable in 83%. Anti DGP IgA

antibodies were positive in 1of 88 (1.1%), and equivocal in 2 of 88(2.3%).

Conclusion: The prevalence of celiac disease among female university students is

aligns with the high background prevalence in Syria. These findings underscore the

need for increased awareness and targeted screening in this young adult population

to enable timely diagnosis and management with a gluten-free diet