الصفحة 1
الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontology Matching
Euzenat and Shvaiko’s book is devoted to ontology matching as a solution to the semantic heterogeneity problem faced by computer systems. Ontology matching aims at finding correspondences between semantically related entities of different ontologies. These correspondences may stand for equivalence as well as other relations, such as consequence, subsumption, or disjointness, between ontology entities.
Online Storage Systems and Transportation Problems with Applications : Optimization Models and Mathematical Solutions
This books covers the analysis and development of online algorithms involving exact optimization and heuristic techniques, and their application to solve two real life problems. The first problem is concerned with a complex technical system: a special carousel based high-speed storage system - Rotastore. It is shown that this logistic problem leads to an NP-hard Batch PreSorting problem which is not easy to solve optimally in offline situations. The second problem originates in the health sector and leads to a vehicle routing problem. Reasonable solutions for the offline case covering a whole day with a few hundred orders are constructed with a heuristic approach, as well as by simulated annealing. Optimal solutions for typical online instances are computed by an efficient column enumeration approach leading to a set partitioning problem and a set of routing-scheduling subproblems. The latter are solved exactly with a branch-and-bound method which prunes nodes if they are value-dominated by previous found solutions or if they are infeasible with respect to the capacity or temporal constraints.
Online Marketing
Provides a clear and practice-oriented overview of the basics of online marketing. Short learning units, clear didactic modules and the accompanying learning control ensure a sustainable transfer of knowledge. It is thus aimed at all those who deal with questions of online marketing in the context of their education and training (also as a minor subject) as well as their professional practice.
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
On the move to meaningful internet systems 2006 : OTM 2006 Workshops ; Vol. 4277 ; OTM Confederated International Conferences and Posters, AWeSOMe, CAMS, COMINF, IS, KSinBIT, MIOS-CIAO, MONET, On To Content, ORM, PerSys, OTM Academy Doctoral Consortium, RDDS, SWWS, SeBGIS 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part I
This two-volume set LNCS 4277/4278 constitutes the refereed proceedings of 14 international workshops held as part of OTM 2006 in Montpellier, France in October/November 2006. The 191 revised full papers presented were carefully reviewed and selected from a total of 493 submissions to the workshops. The first volume begins with 26 additional revised short or poster papers of the OTM 2006 main conferences.
On the move to meaningful internet systems 2006 : CoopIS, DOA, GADA, and ODBASE ; Vol. 4276 ; OTM Confederated International Conferences, CoopIS, DOA, GADA, and ODBASE 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part II
A two-volume set, which constitutes the refereed proceedings of the four confederated conferences CoopIS 2006, DOA 2006, GADA 2006, and ODBASE 2006 held as OTM 2006 in Montpellier, France. It contains 106 revised full and 9 short papers, which were carefully reviewed and selected from a total of 361 submissions.
On the move to meaningful internet systems 2006 : CoopIS, DOA, GADA, and ODBASE ; Vol. 4275 ; OTM Confederated International Conferences, CoopIS, DOA, GADA, and ODBASE 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part I
This two-volume set LNCS 4275/4276 constitutes the refereed proceedings of the four confederated conferences CoopIS 2006, DOA 2006, GADA 2006, and ODBASE 2006 held as OTM 2006 in Montpellier, France in October/November 2006. The 106 revised full and nine short papers presented together with four keynote speeches were carefully reviewed and selected from a total of 361 submissions.
On the move to meaningful internet systems 2005 : OTM 2005 Workshops ; OTM Confederated International Workshops and Posters, AWeSOMe, CAMS, GADA. MIOS+INTEROP, ORM, PhDS, SeBGIS. SWWS. and WOSE 2005, Agia Napa, Cyprus, October 31 - November 4, 2005, Proceedings
This book constitutes the joint refereed proceedings of nine international workshops held as part of OTM 2005 in Agia Napa, Cyprus in October/November 2005.The 145 revised full papers presented were carefully reviewed and selected from a total of 268 submissions. Topics addressed are agents, Web services and ontologies merging (AWeSOMe 2005), context-aware mobile systems (CAMS 2005), grid computing and its application to data analysis (GADA 2005), inter-organizational systems and interoperability of enterprise software and applications (MIOS+INTEROP 2005), object-role modeling (ORM 2005), a PHD symposium (PhDS 2005), semantic-based geographical information systems (SeBGIS 2005), Web semantics (SWWS 2005), and ontologies, semantics and e-learning (WOSE 2005)
On the move to meaningful internet systems 2005 : CoopIS, DOA, and ODBASE ; Vol. 3761 : OTM Confederated International Conferences, CoopIS, DOA, and ODBASE 2005, Agia Napa, Cyprus, October 31 - November 4, 2005, Proceedings, Part II
Constitutes the refereed proceedings of the three confederated conferences CoopIS 2005, DOA 2005, and ODBASE 2005 held as OTM 2005 in Agia Napa, Cyprus in October/November 2005. This title presents 89 revised and 7 short papers together with 3 keynote speeches that were reviewed and selected from a total of 360 submissions.
On the move to meaningful internet systems : OTM 2008 Workshops ; OTM Confederated International Workshops and Posters, ADI, AWeSoMe, COMBEK, EI2N, IWSSA, MONET, OnToContent + QSI, ORM, PerSys, RDDS, SEMELS, and SWWS 2008, Monterrey, Mexico, November 9-14, 2008. Proceedings
This volume constitutes the refereed proceedings of 13 international workshops held as part of OTM 2008 in Monterrey, Mexico, in November 2008.The 106 revised full papers presented were carefully reviewed and selected from a total of 171 submissions to the workshops. The volume starts with 19 additional revised poster papers of the OTM 2008 main conferences CoopIS and ODBASE. Topics of the workshop papers are ambient data integration (ADI 2008), agents and web services merging in distributed environment (AWeSoMe 2008), community-based evolution of knowledge-intensive systems (COMBEK 2008), enterprise integration, interoperability and networking (EI2N 2008), system/software architectures .
omputational science and its applications - ICCSA 2005 ; Vol. 3480 ; International Conference, Singapore, May 9-12, 2005, Proceedings, Part I
The four volume set assembled following The 2005 International Conference on Computational Science and its Applications, ICCSA 2005, held in Suntec International Convention and Exhibition Centre, Singapore, from 9 May 2005 till 12 May 2005, represents the ?ne collection of 540 refereed papers selected from nearly 2,700 submissions. Computational Science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry. Due to the shear size of many challenges in computational science, the use of supercomputing, parallel processing, and - phisticated algorithms is inevitable and becomes a part of fundamental t- oretical research as well as endeavors in emerging ?elds.
Oil Spill Response : A Global Perspective
This book provides a timely international perspective on applied research and development, technology transfer, and “lessons learned” from field trials and actual case studies associated with recent spill events. This book provides a synopsis as to the methods currently employed to deals with spills and an insight on future technologies under development.
Offshore Risk Assessment : Principles, Modelling and Applications of QRA Studies
This updated and expanded second edition has been informed by a major R&D programme on offshore risk assessment in Norway (2002–2006), and reflects the trend of expanded use of floating production installations. It starts with a thorough discussion of risk metrics and risk analysis methodology with subsequent chapters devoted to analytical approaches to escalation, escape, evacuation and rescue analysis of safety and emergency systems. Separate chapters analyse the main hazards of offshore structures: fire, explosion, collision and falling objects. Risk mitigation and control are discussed, as well as an illustration of how the results from quantitative risk assessment studies should be presented. The second edition has a stronger focus on the use of risk assessment techniques in the operation of offshore installations. Also decommissioning of installations is covered.
Oculoplastics and Orbit
This book have been provided throughout each chapter. evidence-based medicine into clinical practice.It is reasonable to now update our With the start of the second cycle of subspecialty readers with what has been achieved. coverage, the dissemination of practical inform- a Te immediate goal was to transfer inform- a tion will be continued as we learn more about tion through a high quality quarterly publication the emerging advances in various ophthalmic in which ophthalmology would be represented by subspecialties that can be applied to obtain the eight subspecialties.
Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Object-Oriented Technology. ECOOP 2007 Workshop Reader ; ECOOP 2007 Workshops, Berlin, Germany, July 30-31, 2007, Final Reports
Contains the reports from the workshopsheld at the 21st European Conference on Object-Oriented Programming - ECOOP 2007 - at Technische Universit] at Berlin. Nineteen workshops were heldin the courseofthis conference on July 30 and July 31, 2007, covering a large spectrum of hot research topics. As in previous editions of ECOOP, numerous scientists from academia and industry took the chance to present innovative and topical ideas in an environment ofering optimal conditions for exciting discussions and fruitful interactions. The Workshop Reader which contains the reports from the workshops has been a substantial part of the ECOOP conference for more than10 years
Nutrition in Kidney Disease
The field of kidney disease has evolved over the years to encompass a broad and sophisticated knowledge base. There has been a proliferation of scientific information and technical advances in the field. In Nutrition in Kidney Disease, the authors provide a comprehensive perspective of the emerging science in nutrition in kidney disease. This important book is written by a collaborative group of distinguished dietitians and physicians in the specialized field of kidney disease and clinical nutrition, who have devoted their careers to the care of patients with kidney disease. At the end of key chapters, case studies assess knowledge of the subject within the context of didactic curriculums.
Nutraceuticals in obesity management and control
Provides detailed information on nutraceuticals that can be helpful in the control and management of obesity. It clarifies key aspects of nutraceuticals that include sources, extraction, chemistry, mechanisms of action, pharmacology, bioavailability, safety, and various applications. Beginning with a concise overview of the prevalence of obesity, complications related to obesity, and current treatment regimens, the volume delves into the roles of functional foods and nutraceuticals for the management of body weight and for alleviating obesity comorbidities. It goes on to discuss the effect of some of the most commonly and frequently used naturally occurring nutraceutical substances, along with their mechanisms of action in controlling obesity. The volume looks at the role of nutraceutical fruits as well as the beneficial aspects of carotenoids in fruits and vegetables and explores antioxidant-rich nutraceuticals, the role of vitamins and supplements, the use of green tea, and the potential of pseudocereals and spices in the management of metabolic syndrome.
Numerical solution of Variational Inequalities by Adaptive Finite Elements
Franz-Theo Suttmeier describes a general approach to a posteriori error estimation and adaptive mesh design for finite element models where the solution is subjected to inequality constraints. This is an extension to variational inequalities of the so-called Dual-Weighted-Residual method (DWR method) which is based on a variational formulation of the problem and uses global duality arguments for deriving weighted a posteriori error estimates with respect to arbitrary functionals of the error. In these estimates local residuals of the computed solution are multiplied by sensitivity factors which are obtained from a numerically computed dual solution. The resulting local error indicators are used in a feed-back process for generating economical meshes which are tailored according to the particular goal of the computation.
