الصفحة 1
الصفحة 1
Oncofertility : Fertility Preservation for Cancer Survivors
While cancer survival rates have increased steadily over the last several decades, particularly among younger patients, the more aggressive forms of treatment that have made this possible often compromise a cancer patient's ability to later have biological children. In the past, pregnancy after cancer was largely unheard of. Today it is increasingly a possibility due to high survivorship rates in general and emerging reproductive technologies that give patients and their families options at the time of diagnosis to ensure a patient's future fertility (cryopreservation of ovarian tissue).
Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting
ompiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes
Obesity and Cancer
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development.
Nutritional Management of the Surgical Patient
Provides the first comprehensive evidence-based overview of the nutritional and dietary therapies for surgical patients. It takes clinicians through every stage of surgery, from pre-operative and immediate post-operative care, through to long term recovery and survivorship. This book describes the impact of surgical procedures and their complications and the effect these have on nutritional status as well as the nutritional strategies utilised to manage patients in these settings.
Novel mouse model for future autism research
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the first 3 years of life. It is not a single disorder, and it is broadly considered to be a multi-factorial disorder resulting from genetic and non-genetic risk factors and their interaction. Genetic studies of ASD have identified mutations that interfere with typical neurodevelopment in utero through childhood. These complexes of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have provided many important insights into the pathological changes that occur in the brain of patients with ASD in vivo. Especially, the role of amygdala, a major component of the limbic system and the affective loop of the cortico-striatothalamo-cortical circuit, in cognition and ASD has been proved in numerous neuropathological and neuroimaging studies.
New Perspectives in the Study of Mesoamerican Primates : Distribution, Ecology, Behavior, and Conservation
The purpose of this volume is to present a comprehensive overview of recent advances in primate field research, ecology, and conservation biology in Mesoamerica. The overall goal of each contribution is to integrate newly collected field data with theoretical perspectives drawn from evolutionary biology, socioecology, biological anthropology, and conservation to identify how our current knowledge of primate behavior and ecology has moved beyond more traditional approaches. A corollary to this, and an important goal of the volume is to identify geographical regions and species for which we continue to lack sufficient information, to develop action plans for future research, and to identify areas for immediate conservation action. Despite many decades of primate research in Mesoamerica, much is still unknown concerning the basic ecology and behavior of these species, demography, current distribution, and conservation status of local populations, and the effectiveness of conservation policies on primate survivorship. Four major areas of research are the focus of the volume: Evolutionary Biology and Biogeography; Population Demography and Ecology; Behavior; and Conservation and Management Policies.
Neuronal cell death : Methods and protocols
Covers comprehensive methods on ways to assess structural and ultrastructural changes in the mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques including super-resolution imaging, electron microscopy, and ultra-high field MRI. The chapters in this book cover topics such as analysis of neurodegeneration in the post-mortem characterization of preclinical animal models, in vivo modeling in cell death in different model systems and brain organoids, single cell clonal analysis using Mosaic Analysis with Double Markers in genetic mouse models, and genome and proteomic methods for analysis of mRNA dynamics and quantitation of targeted peptides.
Nanopharmaceuticals ; Vol.1 : Expectations and realities of multifunctional drug delivery systems
Reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.
Nanopharmaceuticals : Vol.3 : Principles and applications
Focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Multifunctional Pharmaceutical Nanocarriers
Various pharmaceutical nanocarriers, such as nanospheres,nanocapsules, liposomes, micelles, cell ghosts, lipoproteins and some others are widely used for experimental (and already clinical) delivery of therapeutic and diagnostic agents. The use of nanoparticulate pharmaceutical carriers to enhance the in vivo efficiency of many drugs well established itself over the past decade both in pharmaceutical research and clinical setting.
MR Imaging in White Matter Diseases of the Brain and Spinal Cord
Comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.
Mouse Models of Human Blood Cancers : Basic Research and Pre-clinical Applications
Although it remains an open question among some people whether mice and humans are similar in disease development, the laboratory mouse has emerged as the preeminent animal model for human diseases. This is underscored by the recently completed mouse and human genome projects, which have revealed that mice and humans share the vast majority of their genes, and thus get many of the same diseases, and for the same reasons. Emphasizing why mouse models are valuable in vivo systems for understanding disease mechanisms and developing therapeutic strategies for human blood cancers, "Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications," edited by Shaoguang Li, aims on presenting thorough analyses of the pathological features and the molecular bases of several major types of blood cancer and to describe translational research using mouse cancer models.
Molecular Technology ; Vol.2 : Life Innovation
Interdisciplinary and application-oriented, this ready reference focuses on methods and processes with a high practical aspect, covering new trends in drug delivery, in-vivo analysis, structure formation and much more.
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes
Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes features important insights into the applications of fullerenes and carbon nanotubes. It discusses the fullerene and nanotubes derivatives which are effective against viruses, cells, and bacteria and those which are able to interact and inhibit certain enzymes. Also covered in this book are the formation of complex structures between biologically active molecules and carbon materials. Furthermore, the application of fullerenes in certain medical therapies is explored, including the very recent discovery of new bio-compatible media which could be used as carriers in the delivery of fullerenes in vivo. An additional topic of this text is the formation of hybrids between nanotubes and biological molecules and their use as chemical sensors.
Interventions for Persisting Ductus Arteriosus in the Preterm Infant
Over the past few years a remarkably rapid evolution in the professional level of neonatology and in the survival of immature infants has been witnessed. Persisting ductus arteriosus is common in this population and is associated with impaired longterm outcome. Many uncertainties exist concerning indication, approach, best time, and side effects of necessary measurements and interventions to avoid later neurodevelopmental handicaps of the survivors. Experts in neonatology and pediatric cardiology give their opinion in this book. We are sure it will help to define the level of evidence and to develop standards of intervention for persisting ductus arteriosus in Europe. Adequate dealing with the ductus will become a challenge for every perinatal center.
Innovative dosage forms : Design and development at early stage
Provides information that is essential for the drug development effort Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals Describes current approaches in early pre-formulation to achieve the best in vivo results Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design
In Vivo Models of Inflammation ; Vol. II
In Vivo Models of Inflammation (Vol. 2) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation.
In Vivo Models of Inflammation ; Vol. I
In Vivo Models of Inflammation (Vol. 1) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation.
In vivo Models of HIV Disease and Control
An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.
In Vivo Imaging of Cancer Therapy
In Vivo Imaging of Cancer Therapy addresses a variety of cutting-edge imaging techniques, including their use for best practice, and provides examples of results found in both pre-clinical and clinical studies. This comprehensive text covers the entire spectrum of in vivo imaging for oncology, including current approaches to detailed anatomic measurements, MR and optical spectroscopy, and molecular imaging techniques requiring exogenously administered imaging agents. The challenges and approaches to quantification are also outlined. The authors describe technologies and methods that are currently clinically available, and many that are still in a developmental stage or useful only in animal studies.
