الصفحة 1
الصفحة 1
Transdermal Drug Delivery System Patch of Testosterone
Transdermal Drug Delivery System is a medicated way to administer the active ingredient by the skin; the adhesive patch is the major representation of this system. It is placed on the healthy skin to transfer the medication through the dermas then into the bloodstream.” TDDS” historically used since 19th century. In comparison with other formulations, it has many advantages. Meanly avoidance of first pass metabolism. Several types of TDDS are prepared, they differ by the number of layers and components. Some examples have been cited and modern technology, like nanocarrier, is used in TDDS. One of the APIs used in TDDS is Testosterone; this hormone is produced by human body, secreted in stable amount, when it decreases it causes important troubles. We mention that this kind of pharmaceutical form is missed in our country (Syria) so, we studied the possibility to prepare this form in our research lab. And we take the Testosterone as API of our works.
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
Behavioral medicinal therapy for ADHD & transdermal patches
ADHD is a popular disorder, often diagnosed in children in young ages. we aimed our study to focus on this disorder since it has a great impact on education and academic achievement. Although its widespread recently more than last twenty years, but in our survey we noticed that the reported cases in Syrian ministry of education is much lower than we observed in our practical clinical study. We will present the history, symptoms, risk factor, prognosis and therapy of this disorder with comparative study between two forms of treatment. According to this research and our practical work, we will find the best choice in treatment after diagnosed with ADHD
