الصفحة 1
الصفحة 1
Open and Toroidal Electrophoresis : Ultra-High Separation Efficiencies in Capillaries, Microchips and Slabs
Written by one of the developers of Toroidal Capillary Electrophoresis (TCE), this book is the first to present this novel analytical technique, in detail, to the field of analytical chemistry. The exact expressions of separation efficiency, resolution, peak capacity, and many other performance indicators of the open and toroidal layouts are presented and compared.
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontology Matching
Euzenat and Shvaiko’s book is devoted to ontology matching as a solution to the semantic heterogeneity problem faced by computer systems. Ontology matching aims at finding correspondences between semantically related entities of different ontologies. These correspondences may stand for equivalence as well as other relations, such as consequence, subsumption, or disjointness, between ontology entities.
Ontology Learning and Population from Text: Algorithms, Evaluation and Applications
Ontology Learning and Population from Text: Algorithms, Evaluation and Applications presents approaches for ontology learning from text and will be relevant for researchers working on text mining, natural language processing, information retrieval, semantic web and ontologies. Containing introductory material and a quantity of related work on the one hand, but also detailed descriptions of algorithms, evaluation procedures etc. on the other, this book is suitable for novices, and experts in the field, as well as lecturers.
Ontologies for Urban Development
Action C21 of the European programme for Cooperation in the field of Scientific and Technical Research (COST—http://www.cost.esf.org/) is dedicated to investigating urban ontologies for an improved communication in urban civil engineering projects. The Action, known informally as "Towntology", brings together a large and heterogeneous grouping from across Europe, whose interests range from construction to urban tourism and from transport infrastructure to resource visualisation. On 6-7 November 2006, in Geneva, the Action convened a successful workshop to address emerging issues in the field. This volume presents the contributions to that workshop, in many cases revised afterwards to capture some of the outcomes of discussion.
Ontologies for Agents : Theory and Experiences
On the other hand, ontologies have established themselves as a powerful tool to enable kno- edge sharing, and a growing number of applications have bene?ted from the use of ontologies as a means to achieve semantic interoperability among heterogeneous, distributed systems. In principle ontologies and agents are a match made in heaven, that has failed to happen. What makes a simple piece of software an agent is its ability to communicate in a ”social” environment, to make autonomous decisions, and to be proactive on behalf of its user. Communication ultimately depends on und- standing the goals, preferences, and constraints posed by the user. Autonomy is theabilitytoperformataskwithlittleornouserintervention,whileproactiveness involves acting autonomously with no need for user prompting. Communication, but also autonomy and proactiveness, depend on knowledge. The ability to c- municate depends on understanding the syntax (terms and structure) and the semantics of a language. Ontologies provide the terms used to describe a domain and the semantics associated with them. In addition, ontologies are often comp- mented by some logical rules that constrain the meaning assigned to the terms. These constraints are represented by inference rules that can be used by agents to perform the reasoning on which autonomy and proactiveness are based.
One hundred years of social protection : The changing social question in Brazil, India, China, and South Africa
As the first in-depth study of the ideational foundations of social protection policies and programmes in these four countries, the contributions demonstrate that the social question was articulated in an increasingly inclusive way.
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
Oncology : An Evidence-Based Approach
Reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor immunology.
Once upon a time : illustrations from fairytales, fables, primers, pop-ups, and other children's books
The 1905 obituary of John McLoughlin, Jr., in Publisher's Weekly declared,?Every child in the land knows the McLoughlin books. ... In fact, the history in the last decade of colored toy books for youngsters is the history of Mr. McLoughlin and his firm.?
On the Topology of Isolated Singularities in Analytic Spaces
The aim of this book is to give an overview of selected topics on the topology of real and complex isolated singularities, with emphasis on its relations to other branches of geometry and topology. The first chapters are mostly devoted to complex singularities and a myriad of results spread in a vast literature, which are presented here in a unified way, accessible to non-specialists. Among the topics are the fibration theorems of Milnor; the relation with 3-dimensional Lie groups; exotic spheres; spin structures and 3-manifold invariants; the geometry of quadrics and Arnold's theorem which states that the complex projective plane modulo conjugation is the 4-sphere. The second part of the book studies pioneer work about real analytic singularities which arise from the topological and geometric study of holomorphic vector fields and foliations. In the low dimensional case these turn out to be related to fibred links in the 3-sphere defined by meromorphic functions. This provides new methods for constructing manifolds equipped with a rich geometry.
On the path to AI : Law’s prophecies and the conceptual foundations of the machine learning age
This book explores machine learning and its impact on how we make sense of the world. It does so by bringing together two ‘revolutions’ in a surprising analogy: the revolution of machine learning, which has placed computing on the path to artificial intelligence, and the revolution in thinking about the law that was spurred by Oliver Wendell Holmes Jr in the last two decades of the 19th century.
On the move to meaningful internet systems 2007 : OTM 2007 Workshops ; OTM Confederated International Workshops and Posters, AWeSOMe, CAMS, OTM Academy Doctoral Consortium, MONET, OnToContent, ORM, PerSys, PPN, RDDS, SSWS, and SWWS 2007, Vilamoura, Portugal, November 25-30, 2007,
it is clear that there is an acute and increasing need to address and discuss in an integrated forum the implied software and system issues as well as methodological, semantical, theoretical and application issues. As we all know, e-mail, the Internet, and even video conferences are not sufficient for effective and efficient scientific exchange. This is why the OnTheMove (OTM) Federated Conferences series has been created to cover the increasingly wide yet closely connected range of fundamental technologies such as data and Web Semantics.
On the move to meaningful internet systems 2006 : CoopIS, DOA, GADA, and ODBASE ; Vol. 4275 ; OTM Confederated International Conferences, CoopIS, DOA, GADA, and ODBASE 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part I
This two-volume set LNCS 4275/4276 constitutes the refereed proceedings of the four confederated conferences CoopIS 2006, DOA 2006, GADA 2006, and ODBASE 2006 held as OTM 2006 in Montpellier, France in October/November 2006. The 106 revised full and nine short papers presented together with four keynote speeches were carefully reviewed and selected from a total of 361 submissions.
On the move to meaningful internet systems 2005 : CoopIS, DOA, and ODBASE ; Vol. 3761 : OTM Confederated International Conferences, CoopIS, DOA, and ODBASE 2005, Agia Napa, Cyprus, October 31 - November 4, 2005, Proceedings, Part II
Constitutes the refereed proceedings of the three confederated conferences CoopIS 2005, DOA 2005, and ODBASE 2005 held as OTM 2005 in Agia Napa, Cyprus in October/November 2005. This title presents 89 revised and 7 short papers together with 3 keynote speeches that were reviewed and selected from a total of 360 submissions.
Omega-3 fatty acids : Keys to nutritional health
Argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health.
Omega 3 and Omega 6 and its relationship to obesity
This research summarizes information about omega-3 and omega-6. In recent times, there has been growing recognition of the key role of foods and beverages in disease prevention and treatment. Thus, the production and consumption of functional foods has gained much importance as they provide a health benefit beyond the basic nutritional functions. At present, PUFA (poly unsaturated fatty acids) as Omega-3 [(n-3)] fatty acids and Omega -6 [(n-6)] fatty acid have been linked to healthy aging throughout life. Recently, omega-3 fatty acids EPA (eicosapentaenoic acid ) and DHA (docosahexaenoic acid ) have been associated with cardiovascular function, and Alzheimer’s disease.
Olfactory knows the truth
Olfaction, the sense of smell detects and discriminate odors as well as social cues which influence our innate responses. The olfactory system in human beings is found to be weak as compared to other animals; however, it seems to be very precise. It can detect and discriminate millions of chemical moieties (odorants) even in minuscule quantities. The sense of smell is greatly underappreciated, despite the fact that it monitors the intake of airborne agents into the human respiratory system and determine to a large degree the flavor and palatability of foods and beverage. In addition to enhancing quality of life, this primary sensory system warns of spoiled foods, leaking natural gas, polluted air and smoke, and mediates basic elements of communication (e.g., mother-infant interaction). It is now apparent that smell dysfunction is among the first clinical signs of such neurodegenerative diseases as Alzheimer’s disease and sporadic Parkinson’s disease.
Old Buildings New Designs
Increasingly, architects are hired to design new work for existing structures. Whether for reasons of preservation, sustainability, or cost-effectiveness, the movement to reuse buildings presents a variety of design challenges and opportunities. Old Buildings, New Designs is an Architecture Brief devoted to working within a given architectural fabric from the technical issues that arise from aging construction to the controversy generated by the various project stakeholders to the unique aesthetic possibilities created through the juxtaposition of old and new.
Old and New Perspectives on Mortality Forecasting
This book describes methods of mortality forecasting and discusses possible improvements. It contains a selection of previously unpublished and published papers, which together provide a state-of-the-art overview of statistical approaches as well as behavioural and biological perspectives. The different parts of the book provide discussions of current practice, probabilistic forecasting, the linearity in the increase of life expectancy, causes of death, and the role of cohort factors.
