الصفحة 1
الصفحة 1
Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Neurocutaneous disorders : A clinical, ciagnostic and therapeutic approach
Provides extensive data on the more common and many of the more rare congenital and hereditary syndromes that manifest in the nervous system and skin. Though often complex and multi-systemic, these disorders can frequently be diagnosed using a combination of simple visual inspection and sound clinical expertise. Drawing on fully referenced information from thousands of articles, the international editorial team has prepared a comprehensive overview that includes historical perspectives, clinical features, the pathogenesis, and diagnostic and therapeutic strategies. In addition, it addresses the biochemical, molecular, and genetic basis of the disorders.
Museum Digitisations and Emerging Curatorial Agencies Online : Vikings in the Digital Age
This book explores the multiple forms of curatorial agencies that develop when museum collection digitisations, narratives and new research findings circulate online. Focusing on Viking Age objects, it tracks the effects of antagonistic debates on discussion forums and the consequences of search engines, personalisation, and machine learning on American-based online platforms. Furthermore, it considers eco-systemic processes comprising computation, rare-earth minerals, electrical currents and data centres and cables as novel forms of curatorial actions.
Multigenic and Induced Systemic Resistance in Plants
This comprehensive volume consists of a series of up-to-date reviews, each incorporating current models and knowledge related to mechanisms of resistance either expressed constitutively or induced systemically in plants. Each chapter covers a topic related to the phenomenon of plant resistance to fungal and bacterial pathogens, insects, nematodes, viruses or abiotic stress in plants, as well as the application of this knowledge to protect crops now and in the future. Researchers, upper-level undergraduate and graduate students, and those teaching courses in plant physiology, entomology and plant pathology will find this volume a much needed asset.
Monographs in contact allergy ; Vol.4 : Systemic drugs
Presents : Identification section; Occupational allergic contact dermatitis; and Cutaneous adverse drug reactions from systemic drugs caused by type IV (delayed-type) hypersensitivity, as shown by positive patch tests (e.g. maculopapular eruption, acute generalized exanthematous pustulosis [AGEP], symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], fixed drug eruption, drug reaction with eosinophilia and systemic symptoms [DRESS], and photosensitivity). Separate chapters present an overview of the spectrum of allergic cutaneous drug reactions, diagnostic tests, immediate contact reactions (contact urticaria), and systemic drugs that have acquired delayed-type hypersensitivity only by cross-reactivity.
Mission AI: the new system technology
Offers a strategic perspective on AI and the process of embedding it in society. After decades of research, Artificial Intelligence (AI) is now entering society at large. Due to its general purpose character, AI will change society in multiple, fundamental and unpredictable ways. Therefore, the Netherlands Scientific Council for Government Policy (WRR) characterizes AI as a system technology: a rare type of technologies that have a systemic impact on society. Earlier system technologies include electricity, the combustion engine and the computer. The history of these technologies provides us with useful insights about what it takes to direct the introduction of AI in society.
Migration and Discrimination : IMISCOE Short Reader
This book provides a state of the art overview of the discrimination research field, with particular focus on discrimination against immigrants and their descendants. It covers the ways in which discrimination is defined and conceptualized, how it is measured, how it may be theorized and explained, and how it might be combated by legal and policy means.
Methods of Cancer Diagnosis, Therapy and Prognosis : Breast Carcinoma
Focusing on Breast Carcinoma, this first volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis brings together 56 leading scientists from around the world to deliver a comprehensive treatise on all aspects of breast cancer, including diagnosis, treatments and prognosis.
Mesoscale Analysis of Hydraulics
Presents a series of complicated hydraulic phenomena and related mechanism of high-speed flows in head-head dam. According to the basic hydraulic theory, detailed experiments and numerical simulations, microscopic scale analysis on cavitation bubbles, air bubbles, turbulent eddy vortices and sand grains are examined systemically. These investigations on microscopic fluid mechanics, including cavitation erosion, aeration protection, air–water flow, energy dissipation and river-bed scouring, allow a deep understanding of hydraulics in high-head dams. This book provides reference for designers and researchers in hydraulic engineering, environment engineering and fluid mechanics.
Introduction to Systems Biology
Informative and cutting-edge, this volume presents a clear and intuitive illustration of the biological systemic approaches and introduces ideal computational methods for research. Introduction to Systems Biology is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.
Introduction to basics of pharmacology and toxicology ; Vol.2 : Essentials of systemic pharmacology : From principles to practice
Describes the pharmacology of drugs acting on different systems in the human body Analyses various human diseases and the pharmacological agents governing them Provides a valuable reference resource for academicians, researchers, and clinical practitioners Offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics.
Intraperitoneal Cancer Therapy
The volume details major clinical trails to date, including immunotherapy, hyperthermic treatment of colo-rectal and ovarian cancers. Authors also examine regional approaches to therapy, systemic therapy, and the use of carboplatin and paclitaxel as the standard treatment for women with stages III and IV ovarian cancer. Other chapters also investigate techniques and procedures in treatment, as well as the future direction of both normothermic and hyperthermic intraperitoneal chemotherapy.
Internationalization and Economic Policy Reforms in Transition Countries
The project is devoted to analyzing the internationalization of the Russian economy and the associated changes in major policy fields. This book contains the revised analytical papers from the St. Petersburg conference in 2003 when the city celebrated its 300 year anniversary. We are very grateful to the Leontief Center for excellent organization of the conference.
Internal medicine for dental treatments: patients with medical diseases
Illustrates the precautions for dental treatment with patients with medical diseases and presents the correlation and relationship between oral symptoms and systemic diseases. It is organized into two parts; the first part is symptomatology presenting the description of some symptoms as general remarks. Then comes the part explaining the diseases, which describe the associations between each medical disease and the oral conditions. Chapters provide intraoral figures and in-depth information to help readers understand the symptoms, mechanisms, and responses, the comorbidities, and medications.
Intelligent Organizations : Powerful Models for Systemic Management
This innovative book opens a path to overcoming the crisis of management in the face of complexity. The systems approach on which this work is grounded enables the development of the new kind of intelligent organizations so urgently needed. Powerful models, grounded in organizational cybernetics and system dynamics
Innovation Policy in a Knowledge-Based Economy : Theory and Practice
Why Analyze Innovation Policies From a Knowledge- Based Perspective? It is broadly accepted that we have moved (or are moving) to a knowled- based economy, characterized at least by two main features: that knowl edge is a major factor in economic growth, and innovation processes are systemic by nature. It is not surprising that this change in the economic paradigm requires new analytical foundations for innovation policies. One of the purposes of this book is to make suggestions as to what they should include. Underpinning all the chapters in this book is a conviction of the impor tance of dynamic and systemic approaches to innovation policy. Nelson and Arrow saw innovation and the creation of new knowl edge as the emergence and the diffusion of new information, characterized essentially as a public good. The more recent theoretical literature regarded the rationale for innovation policies as being to provide solutions to "mar ket failures". Today, however, knowledge is seen as multidimensional (tacit vs. codified) and open to interpretation. Acknowledging that the creation, coordination and diffusion of knowledge are dynamic and cumu lative processes, and that innovation processes result from the coordination of distributed knowledge, renders the "market failure" view of innovation policies obsolete. Innovation policies must be systemic and dynamic
Innovation in European Freight Transportation : Basics, Methodology and Case Studies for the European Markets
Serious problems and risks can be observed in European freight transportation development. However, the transport and logistics sector shows a lack of tradition in utilising systematic innovation management to overcome these problems. Hence, this volume puts forward a specific and comprehensive Systemic Migration-Oriented Innovation Management Method.
Inflammatory Bowel Disease : From Bench to Bedside
Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders are explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.
Inflammation and natural products ; 1st ed.
Brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes.
Higher Education in Romania : Overcoming Challenges and Embracing Opportunities
The book focuses on areas of interest for Romanian higher education, such as systemic measures to improve access, participation and completion for (vulnerable) students, better promotion of the Romanian higher education to attract students, as well as instruments for a more efficient use of data at higher education level. Each article includes evidence-based policy proposals that could support new strategic initiatives in higher education, including new legislation.
