الصفحة 1
الصفحة 1
Oncology : An Evidence-Based Approach
Reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor immunology.
Numerical Mathematics and Advanced Applications ; Proceedings of ENUMATH 2005 the 6th European Conference on Numerical Mathematics and Advanced Applications, Santiago de Compostela, Spain, July 2005
This book include applications such as atmosphere and ocean, water pollution, electromagnetism, interface problems, waves, finance, heat transfer, unbounded domains, numerical linear algebra, convection-diffusion, fluid-structure, plates, solids, hyperbolic equations, multiphase flow, Navier-Stokes, singular perturbation problems, non linear PDE, control, parabolic equations, as well as methodologies such as a posteriori error estimates, discontinuous Galerkin methods, multiscale methods, optimization, adaptive methods, domain decomposition techniques, exponential integrators, hp-finite elements, level set methods, fractional step methods, penalty procedures, and finite volumes. The book gives an extensive overview of the most recent research in scientific computing, providing to the reader the latest developments concerning the mathematical issues and the applications of this active field of science.
Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Nonlinear Partial Differential Equations with Applications
This book primarily concerns quasilinear and semilinear elliptic and parabolic partial differential equations, inequalities, and systems. It balances the abstract functional-analysis approach based on nonlinear monotone, pseudomonotone, weakly continuous, or accretive mappings with concrete partial differential equations in their weak (or more general) formulation. Methods of Galerkin or of Rothe are exposed in a large generality. Other methods include various direct methods, regularization, or fixed points. The exposition leads general theory as fast as possible towards the analysis of concrete equations, which have specific applications in continuum (thermo-) mechanics of solids and fluids, electrically (semi-) conductive media, modelling of biological systems, or in mechanical engineering. Selected parts are rather an introduction into the subject while some others form an advanced textbook. The intended audience is graduate and PhD students and researchers in the theory of partial differential equations or in mathematical modelling of distributed parameter systems.
Nonlinear Finite Element Methods
Finite element methods have become ever more important to engineers as tools for design and optimization, now even for solving non-linear technological problems. However, several aspects must be considered for finite-element simulations which are specific for non-linear problems: These problems require the knowledge and the understanding of theoretical foundations and their finite-element discretization as well as algorithms for solving the non-linear equations. This book provides the reader with the required knowledge covering the complete field of finite element analyses in solid mechanics.
Nonlinear Dielectric Phenomena in Complex Liquids
Complex liquids constitute a basic element in modern materials science; their significant features include self-assembly, mesoscale structures, complex dynamics, unusual phases and enormous sensitivity to perturbations. Understanding their nature and properties are a great challenge to modern materials science that demands novel approaches. This book focuses on nonlinear dielectric phenomena, particularly on nonlinear dielectric spectroscopy (NDS), which may be considered a possible successor to broadband dielectric spectroscopy (BDS). NDS phenomena directly coupled to mesoscale heterogeneity fluctuations, so information obtained in this way is basically complementary to BDS tests. The book also discusses the application of NDS in a set of complex liquid systems: glassy liquids, liquid crystals, liquids with critical point phenomena, and bio-relevant liquids. The complementary application of NDS and BDS may allow the discovery of universal patterns for the whole category of complex liquids. Written by specialists in the field of nonlinear dielectric studies, theoreticians and experimentalists, ranging from solid state physics to biophysics, the book is organized so that it can serve as a basic textbook for a non-experienced reader.
Nonlinear Continua
This book develops a modern presentation of Continuum Mechanics, oriented towards numerical applications in the fields of nonlinear analysis of solids, structures and fluid mechanics. though the mathematical presentation of the different topics is quite rigorous, an effort is made to link formal developments with engineering physical intuition.
NMR-MRI, µSR and Mössbauer Spectroscopies in Molecular Magnets and magnetic nanoparticles
In this book an extensive overview on the results obtained during the last decade and on recent achievements in the study of molecular magnets by means of Nuclear Magnetic Resonance, Muon Spin Rotation, Magnetic Resonance Imaging and Mossbauer techniques is presented. The aim is to introduce the reader to these techniques and to give a general background on their application to molecular spin systems.
NMR - From Spectra to Structures : An Experimental Approach
Nuclear magnetic resonance spectroscopy is one of the most powerful analytical methods. This practice-oriented textbook aims at teaching how NMR experiments should be used to make structural asssignments. The book is intended as a practical guide for students and laboratory personnel, so that the emphasis is on practical rather than on theoretical aspects, which are treated only to the extent necessary to understand the experiments and to interpret the results.The second edition has been expanded to include several other heteronuclei (15N, 19F, 29Si, 77Se, 113Cd, 117Sn/119Sn, 195Pt, 207Pb) and a new chapter on solid state NMR. The problems section has been enlarged and now includes 50 problems.
New Techniques in Solid-State NMR
After the discovery of nuclear magnetic resonance, [1, 2] the new spectroscopy was used for the study of 1 H nuclei in liquids, but then the signal from copper in the receiver coil itself, the first observation of NMR in the solid state, was found.“Wide-line NMR”, named thus because of the line-broadening effects of dipolar interaction and chemical shift anisotropy, was not far behind, and soon led to significant advances through the analysis of spectral lineshapes. Inthis way Richards and Smith [3] demonstrated the presence of H3O+ cations in solid hydrates of strong acids, while Andrew and Eades [4] investigated the details of molecular motion in three solid benzenes. Even now, 50 years later, it is difficult to think of a technique which would provide a more convincing demonstration of the reality of these effects.
New strategies in treating and diagnosing of Myeloid Leukemia
Leukemia is a cancer of white blood cells. It is characterized by an abnormal accumulation of WBC in the bone marrow which leads to bone marrow failure. in this project, we will observe myeloid leukemias (acute & chronic), Clinical Practice Guidelines for leukemia provide recommendations on the diagnostic evaluation, and applied treatment in Syria and Germany for induction and consolidation for patients and we're going to devote a special paragraph on therapy with monoclonal antibodies. Gilteritinib are new therapies for acute myeloid leukemia and we're going to suggest them in detail.
New Frontiers for design of interior lighting products
Explores the single components that commonly constitute luminaires for interiors, describing their operating principles, families, strengths and weaknesses. It opens with the product classification and main standard requirements. The following chapters describe the different components: light sources, power supplies, thermal dissipation techniques, control technologies, optical systems. The description focuses on the most recent technologies to allow the reader to consider a product design capable of confronting future lighting scenarios. The book provides a simple path addressed to all those who want to try their hand at designing luminaires for interiors, even without a specific engineering background.
Neuro-Oncology of CNS Tumors
Diagnosis and treatment modalities for neuro-oncologic diseases have made considerable advances in recent years. There is hardly a segment of the field of solid tumours that is experiencing such dynamic development with regard to basic scientific findings and clinical results. In the present book the world's leading experts have compiled the current practice-relevant knowledge of neuro-oncologic deseases. The book's clear structure and the uniform presentation of all chapters make this volume a valuable reference, especially for practice-oriented activities, allowing swift access to information about current treatment standards. Hence it will be of great value to both clinicians and researchers.
Nanoscale Devices - Fundamentals and Applications
This book contains a collection of papers giving insight into the fundamentals and applications of nanoscale devices. The main focus is on the synthesis and characterization of nanoscale magnetic materials, the fundamental physics and materials aspects of solid-state nanostructures, the development of novel device concepts and design principles for nanoscale devices, as well as on applications in electronics with special emphasis on defence against the threat of terrorism.
Nanocomposites : Ionic Conducting Materials and Structural Spectroscopies
Nanocomposites have been receiving more and more attention given the improvement of synthesis techniques and the availability of powerful characterization techniques. The aim of the book is to introduce nanocomposite materials using a broad range of inorganic and organic solids. Furthermore, it is intended to present recent and not very common developments in especially spectroscopic characterization techniques, including Mössbauer, EXAFS, NMR. This should make the book attractive for a broad range of readers, including chemists and physicists.
Multiscale fatigue crack initiation and propagation of engineering materials ; Structural integrity and microstructural worthiness : Fatigue crack growth behaviour of small and large bodies
This book elucidates the correlation of fatigue crack growth data to multiscale cracking, particularly to the understanding of micrographs influenced by mechanical disturbance and thermodynamic variables. Attention is given to the interpretation of test data by fatigue crack growth rate using two empirical parameters in consistence with the fracture control methodology currently used by industry.
Multiscale Biomechanics and Tribology of Inorganic and Organic Systems : In memory of Professor Sergey Psakhie
This book gathers authoritative contributions concerning multiscale problems in biomechanics, geomechanics, materials science and tribology. It is written in memory of Sergey Grigorievich Psakhie to feature various aspects of his multifaceted research interests, ranging from theoretical physics, computer modeling of materials and material characterization at the atomic scale, to applications in space industry, medicine and geotectonics, and including organizational, psychological and philosophical aspects of scientific research and teaching as well
Multiphase Reacting Flows : Modelling and Simulation
This book entitled ''Multiphase reacting flows: modelling and simulation'' contains the lecture notes of the CISM (International Centre for Mechanical Sciences) course held in Udine, Italy, on July 3-7, 2006, and it describes various modelling approaches for dealing with polydisperse multiphase reacting flows. A multiphase reacting system is characterized by the presence of multiple phases and in this book we focus on disperse multiphase systems, where one phase can be considered as a continuum, whereas the additional phases are dispersed in the continuous one. In other words, in this book we deal with multiphase systems constituted by particles, droplets or bubbles (i.e., solid particles suspended in a continuous liquid phase, liquid droplets in a gaseous phase, or gas bubbles in liquid.) The other important characteristic elements of the systems discussed in this book are the presence of one or more chemical reactions and the turbulent nature of the flow. The chemical reactions usually involve all the phases present in the system and might be responsible for the formation or disappearance of the disperse and/or continuous phases.
Multifield Problems in Solid and Fluid Mechanics
This book summarizes the main scientific results of the Collaborative Research Center on Multifield Problems in Continuum Mechanics. The book is divided into three main sections: A: Volume-Coupled Problems, devoted to fields which are coupled inside the processing domain or volume, B: Boundary-Coupled Problems, here physical fields and processes are coupled via domain boundaries, C: Fundamental Methods, search into the mathematical concepts and backgrounds of multifield and multiscale modeling.
Multidetector-Row Computed Tomography : Scanning and Contrast Protocols
Multidetector-row computed tomography (MDCT) has advanced the approach to diagnostic assessment of many pathologies and now plays an integral role in imaging of both abdominal and cardiovascular diseases. The possibility to acquire diagnostic images with shorter scan duration, longer scan ranges, and/or thinner sections, MDCT has facilitated the opening of new horizons, such as interventional MDCT and functional imaging in stroke and oncology. In addition, advanced postprocessing techniques now permit high quality volumetric imaging in combination with maximum intensity projections, volume rendering, curved planar reformations and multiplanar reconstructions. This volume gathers contributions by internationally renowned specialists in the field who, through presenting their clinical experience, provide a thorough overview not only of MDCT and its practical applications, but also of workflow management in everyday clinical practice. Focussing on scanning and contrast protocols, the current advantages and disadvantages of non-enhanced vs. enhanced MDCT are discussed, along with insights into likely future developments. The volume represents an up-to-date source of technical and practically-oriented clinical information which should prove of great benefit to all who wish to improve or consolidate their knowledge and expertise in MDCT.
