الصفحة 1
الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Online Storage Systems and Transportation Problems with Applications : Optimization Models and Mathematical Solutions
This books covers the analysis and development of online algorithms involving exact optimization and heuristic techniques, and their application to solve two real life problems. The first problem is concerned with a complex technical system: a special carousel based high-speed storage system - Rotastore. It is shown that this logistic problem leads to an NP-hard Batch PreSorting problem which is not easy to solve optimally in offline situations. The second problem originates in the health sector and leads to a vehicle routing problem. Reasonable solutions for the offline case covering a whole day with a few hundred orders are constructed with a heuristic approach, as well as by simulated annealing. Optimal solutions for typical online instances are computed by an efficient column enumeration approach leading to a set partitioning problem and a set of routing-scheduling subproblems. The latter are solved exactly with a branch-and-bound method which prunes nodes if they are value-dominated by previous found solutions or if they are infeasible with respect to the capacity or temporal constraints.
One Hundred Years of Intuitionism (1907-2007) : The Cerisy Conference
With logicism and formalism, intuitionism is one of the main foundations for mathematics proposed in the twentieth century; and since the seventies, notably its views on logic have become important also outside foundational studies, with the development of theoretical computer science. The aim of the book is threefold: to review and complete the historical account of intuitionism; to present recent philosophical work on intuitionism; and to give examples of new technical advances and applications of intuitionism.
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
On the Way to the Web : The Secret History of the Internet and its Founders
On the Way to the Web: The Secret History of the Internet and Its Founders is an absorbing chronicle of the inventive, individualistic, and often cantankerous individuals who set the Internet free. Michael A. Banks describes how the online population created a new culture and turned a new frontier into their vision of the future. This book will introduce you to the innovators who laid the foundation for the Internet and the World Wide Web, the man who invented online chat, and the people who invented the products all of us use online every day. Learn where, when, how and why the Internet came into being, and exactly what hundreds of thousands of people were doing online before the Web. See who was behind it all, and what inspired them.
On the move to meaningful internet systems 2007 : OTM 2007 Workshops ; OTM Confederated International Workshops and Posters, AWeSOMe, CAMS, OTM Academy Doctoral Consortium, MONET, On To Content, ORM, PerSys, PPN, RDDS, SSWS, and SWWS 2007, Vilamoura, Portugal, November 25-30, 2007, Proceedings, Part II
This two-volume set LNCS 4805/4806 constitutes the refereed proceedings of 10 international workshops and papers of the OTM Academy Doctoral Consortium held as part of OTM 2007 in Vilamoura, Portugal, in November 2007. The first volume begins with 23 additional revised short or poster papers of the OTM 2007 main conferences.
On the move to meaningful internet systems 2007 : CoopIS, DOA, ODBASE, GADA, and IS ; OTM Confederated International Conferences, CoopIS, DOA, ODBASE, GADA, and IS 2007, Vilamoura, Portugal, November 25-30, 2007, Proceedings, Part II
This two-volume set LNCS 4803/4804 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2007), Distributed Objects and Applications (DOA 2007), Ontologies, Databases and Applications of Semantics (ODBASE 2007), Grid computing, high performance and Distributed Applications (GADA 2007), and Information Security (IS 2007) held as OTM 2007 in Vilamoura, Portugal, in November 2007.
On the move to meaningful internet systems 2006 : OTM 2006 Workshops ; Vol.4278 ; OTM Confederated International Conferences and Posters, AWeSOMe, CAMS, COMINF ,IS, KSinBIT, MIOS-CIAO, MONET, On To Content, ORM, PerSys, OTM Academy Doctoral Consortium, RDDS,SWWS,SeBGIS 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part II
This two-volume set LNCS 4277/4278 constitutes the refereed proceedings of 14 international workshops held as part of OTM 2006 in Montpellier, France in October/November 2006. The first volume begins with 26 additional revised short or poster papers of the OTM 2006 main conferences.
On the move to meaningful internet systems 2006 : OTM 2006 Workshops ; Vol. 4277 ; OTM Confederated International Conferences and Posters, AWeSOMe, CAMS, COMINF, IS, KSinBIT, MIOS-CIAO, MONET, On To Content, ORM, PerSys, OTM Academy Doctoral Consortium, RDDS, SWWS, SeBGIS 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part I
This two-volume set LNCS 4277/4278 constitutes the refereed proceedings of 14 international workshops held as part of OTM 2006 in Montpellier, France in October/November 2006. The 191 revised full papers presented were carefully reviewed and selected from a total of 493 submissions to the workshops. The first volume begins with 26 additional revised short or poster papers of the OTM 2006 main conferences.
On the move to meaningful internet systems 2006 : CoopIS, DOA, GADA, and ODBASE ; Vol. 4276 ; OTM Confederated International Conferences, CoopIS, DOA, GADA, and ODBASE 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part II
A two-volume set, which constitutes the refereed proceedings of the four confederated conferences CoopIS 2006, DOA 2006, GADA 2006, and ODBASE 2006 held as OTM 2006 in Montpellier, France. It contains 106 revised full and 9 short papers, which were carefully reviewed and selected from a total of 361 submissions.
On the move to meaningful internet systems 2006 : CoopIS, DOA, GADA, and ODBASE ; Vol. 4275 ; OTM Confederated International Conferences, CoopIS, DOA, GADA, and ODBASE 2006, Montpellier, France, October 29 - November 3, 2006, Proceedings, Part I
This two-volume set LNCS 4275/4276 constitutes the refereed proceedings of the four confederated conferences CoopIS 2006, DOA 2006, GADA 2006, and ODBASE 2006 held as OTM 2006 in Montpellier, France in October/November 2006. The 106 revised full and nine short papers presented together with four keynote speeches were carefully reviewed and selected from a total of 361 submissions.
On the Move to Meaningful Internet Systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part II
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
On the move to meaningful internet systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part I
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
On the construction of engineering handbooks : With an Illustration from the railway safety domain
This book is the first to reflect upon the question of how to construct a desktop handbook. It is demonstrated how concept analysis can be used for identifying settled knowledge as the key ingredient by utilizing the assembled data for classification; a presentation scheme for handbook articles is developed and demonstrated to be suitable. The sketched approach is then illustrated by an example from the railway safety domain. Finally, the limitations of the presented methods are discussed.
omputational science and its applications - ICCSA 2005 ; Vol. 3480 ; International Conference, Singapore, May 9-12, 2005, Proceedings, Part I
The four volume set assembled following The 2005 International Conference on Computational Science and its Applications, ICCSA 2005, held in Suntec International Convention and Exhibition Centre, Singapore, from 9 May 2005 till 12 May 2005, represents the ?ne collection of 540 refereed papers selected from nearly 2,700 submissions. Computational Science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry. Due to the shear size of many challenges in computational science, the use of supercomputing, parallel processing, and - phisticated algorithms is inevitable and becomes a part of fundamental t- oretical research as well as endeavors in emerging ?elds.
olution Sets for Net Zero Energy Buildings : Feedback from 30 Buildings Worldwide
Presents a unique study of 30 NZEBs that have been constructed and have had their performance measured for at least 12 months. The study is based upon an international collaborative research initiated by the International Energy Agency. It is the first book to evaluate building strategies in houses, educational buildings and offices that have been demonstrated to work in practice. It examines how the design challenges of climate and building type have been addressed, and to what extent the various design approaches have been successful. This book presents convincing evidence that a careful re-thinking of conventional design norms can achieve a far greater performance benefit than is normally feasible. It identifies 'solution sets' that work at the whole building level and at the individual building design challenge level for each climate and building type. In doing so, the book provides guidance as to how to improve the design by learning from these cases. Unusually for a book of this type it has examples of buildings in what are conventionally labeled 'hot' and 'cold' climates.
Oil and Security : A World Beyond Petroleum
This book examines the economic impact of changes in the global demand and supply for fossil fuels both on the major producers in Middle Eastern countries around the Persian Gulf, other producers, as well as the world at large. The economic, social and political life of most countries is not only intimately linked to and influenced by the energy market but also affected by historical developments. Among other issues, it shows how the economic, social and political development of societies in Arabia, the peoples of the Arab Peninsula are influenced by their historic and cultural environment, and what the future may bring to this region when their principal economic assets, petroleum and gas, start to lose markets as alternative sources of fossil fuel, alternative, and renewable energy supply the bulk of global energy needs. It also describes how changing fossil fuel costs, access, security of supply, and environmental impacts may affect future economic, social, and political developments as well as technological advances and changes in priorities.
Office-Based Maxillofacial Surgical Procedures : A Step-by-step Approach
This book is a comprehensive, step-by-step guide to maxillofacial surgical procedures typically performed in an office setting. Health care providers will be able to use the book as a resource to expand their knowledge on common maxillofacial surgical procedures.
Obtaining the best from Regulation and Competition
Deregulation has introduced competition into traditionally monopolistic markets, particularly telecommunications and electric utilities. This book brings together ten essays that were presented at the Center for Research in Regulated Industries at Rutgers University and funded by several regulated companies. The authors, who include young scholars as well as established and highly regarded consultants and researchers, address some of the major issues now facing network industries and regulators - deregulation, competition, stranded assets, diversification, pricing, and mergers and acquisitions.
Obstetric life support manual
A comprehensive review in normal and abnormal pregnancy physiology, the most common etiologies of maternal medical emergencies, recognition of maternal deterioration and pending cardiopulmonary arrest, modifications to cardiopulmonary resuscitation in pregnant and postpartum patients, special procedures that can assist in diagnosing and treating maternal medical emergencies tailored to the setting (e.g., point-of-care ultrasound, resuscitative cesarean delivery, extracorporeal cardiopulmonary resuscitation), treatment of trauma/stroke in pregnancy, and postpartum maternal medical emergencies. There are streamlined algorithms and cognitive aids designed to improve a team’s ability to successfully implement techniques unique to treating maternal medical emergencies and car..
