الصفحة 1
الصفحة 1
Olfactory knows the truth
Olfaction, the sense of smell detects and discriminate odors as well as social cues which influence our innate responses. The olfactory system in human beings is found to be weak as compared to other animals; however, it seems to be very precise. It can detect and discriminate millions of chemical moieties (odorants) even in minuscule quantities. The sense of smell is greatly underappreciated, despite the fact that it monitors the intake of airborne agents into the human respiratory system and determine to a large degree the flavor and palatability of foods and beverage. In addition to enhancing quality of life, this primary sensory system warns of spoiled foods, leaking natural gas, polluted air and smoke, and mediates basic elements of communication (e.g., mother-infant interaction). It is now apparent that smell dysfunction is among the first clinical signs of such neurodegenerative diseases as Alzheimer’s disease and sporadic Parkinson’s disease.
Oil Spill Response : A Global Perspective
This book provides a timely international perspective on applied research and development, technology transfer, and “lessons learned” from field trials and actual case studies associated with recent spill events. This book provides a synopsis as to the methods currently employed to deals with spills and an insight on future technologies under development.
Nutrient Acquisition by Plants : An Ecological Perspective
Adaptation and evolution of terrestrial plants depend, to a large extent, on their ability to acquire nutrients. This is a modern and integrative treatment of the mechanisms controlling plant nutrient uptake and how plants respond to changes in the environment. The following key topics are covered: soil nutrient bioavailability; root responses to variations in nutrient supply; nitrogen fixation; regulation of nutrient uptake by internal plant demand; root characteristics; kinetics of nutrient uptake; root architecture; life span; mycorrhizae; responses to climate change. This integrated view helps us to understand the mechanisms that govern present-day plant communities and is indispensable in models designed to predict the response of plants to a changing climate.
Numerical computation, data analysis and software in mathematics and engineering
Include the aspects of the meshless method, numerical simulation, mathematical models, deep learning and data analysis. Meshless methods, such as the improved element-free Galerkin method, the dimension-splitting, interpolating, moving, least-squares method, the dimension-splitting, generalized, interpolating, element-free Galerkin method and the improved interpolating, complex variable, element-free Galerkin method, are presented. Some complicated problems, such as tge cold roll-forming process, ceramsite compound insulation block, crack propagation and heavy-haul railway tunnel with defects, are numerically analyzed.
Nuclear pre-mRNA Processing in Plants
In recent years nuclear pre-mRNA processing has taken center stage as an important regulator of gene expression and ultimately growth and development. Large-scale genome and cDNA sequencing projects together with bioinformatic analyses of these sequences have revealed that alternative splicing of pre-mRNAs contributes greatly to transcriptome and proteome complexity in eukaryotes. During the last few years, tremendous progress has been made in understanding various aspects of pre-mRNA processing including alternative splicing and its importance in plant growth and development as well as in plant responses to hormones and stresses. This book, with contributions from leading scientists in this area, summarizes recent advances in nuclear pre-mRNA processing in plants. It provides researchers in the field, as well as those in related areas, with an up-to-date and comprehensive, yet concise, overview of the current status and future potential of this research in understanding plant biology.
Nuclear and Radiological Emergencies in Animal Production Systems, Preparedness, Response and Recovery
This volume explains how major nuclear and radiological emergencies (NREs) can have implications at local, national and international level. The response to NREs requires a competent decision-making structure, clear communication and effective information exchange. National veterinary services have the responsibility to plan, design and manage animal production system in their countries. These activities cover animal health, animal movement control, production control and improvement, and control of the products of animal origin before their placement on the market.
Nitric oxide in plants : A molecule with dual roles
Studies have identified the central role of nitric oxide in stress mitigation through the modulation of physiological and biochemical pathways including germination, photosynthesis regulation, and programmed cell death. Nitric Oxide in Plants: A Molecule with Dual Roles provides a detailed account of the physio-biochemical, molecular, and omic basis of NO-mediated responses in crop plants under different stresses.
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
New Vision of Metformin in treating cancer
The anti-diabetic drug metformin is rapidly emerging as a potential anticancer agent. Metformin is a biguanide that is effective in treating type 2 diabetes and the insulin resistance syndromes, improves insulin resistance by reducing hepatic gluconeogensis and by enhancing glucose uptake by skeletal muscle. Metformin can reduce the incidence of cancers and can reduce the mortality from cancers, increase the response to treatment cancer cells when using radiotherapy and chemotherapy, reduce the likelihood of relapse. Diabetes can be a factor in the occurrence of various types of cancer, and develop a variety of cancers such as colo-rectal, pancreas and liver cancers, compared to non-diabetic patients. Incidence of various cancers is high among patients of T2DM due to insulin resistance and mitogenic effects caused by hyperglycemia.
New Teacher Identity and Regulative Government : The Discursive Formation of Primary Mathematics Teacher Education
This volume documents in real time the implementation of a major government numeracy programme and its receipt by trainee and new teachers. It shows how such managerialist policies cast teachers as civil servants through de-professionalising the conception of their role. The book provides an easy and accessible commentary utilising contemporary theory to describe how such teachers reconcile their personal aspirations with the external demands they encounter in negotiating their identities as professional teachers. It shows how recent advances in psychoanalytic and post-structuralist theory enable a fresh approach to analysing teacher experience of and response to policy implementation. And more broadly, by situating education in a wider social framework, it shows how we can better formulate solutions to new problems in conceptualising education policy.
New Paradigm for Re-engineering Education : Globalization, Localization and Individualization
In response to the challenges of globalization and local development, educational reforms are inevitably becoming one of the major trends in the Asia-Pacific Region or other parts of the world. Based on the most recent research and international observations, this book aims to present a new paradigm including various new concepts, frameworks and theories for reengineering education. It can provide educators, school leaders and practitioners, educational officials, change agents, researchers, and policy-makers with a comprehensive new perspective to implement educational reforms, enhance leadership, and change school management in a context of globalization, localization and individualization.
New Mechanisms for Tissue-Selective Estrogen-Free Contraception
Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.
New Introduction to Multiple Time Series Analysis
This reference work and graduate level textbook considers a wide range of models and methods for analyzing and forecasting multiple time series. The models covered include vector autoregressive, cointegrated,vector autoregressive moving average, multivariate ARCH and periodic processes as well as dynamic simultaneous equations and state space models. Least squares, maximum likelihood and Bayesian methods are considered for estimating these models. Different procedures for model selection and model specification are treated and a wide range of tests and criteria for model checking are introduced. Causality analysis, impulse response analysis and innovation accounting are presented as tools for structural analysis. The book is accessible to graduate students in business and economics. In addition, multiple time series courses in other fields such as statistics and engineering may be based on it. Applied researchers involved in analyzing multiple time series may benefit from the book as it provides the background and tools for their tasks. It bridges the gap to the difficult technical literature on the topic.
New Insights in Medical Mycology
The aim of this book is to give an in-depth assessment of our current understanding of the Biology of the main fungal pathogens and how they interact with the host’s immune response. Each Chapter focuses on a specific fungal pathogen or group of pathogens and examines their biology and the factors that allow the fungus colonise and disseminate within the host. In addition each Chapter gives an indication of the challenges that remain to be tackled over the next 5 – 10 years in increasing our understanding of fungal pathogenicity.
Networking and Mobile Computing ; 3rd International Conference, ICCNMC 2005, Zhangjiajie, China, August 2-4, 2005, Proceedings
The objective of this conference was to address and capture highly innovative and stateof-the-art research and work in the networks and mobile computing industries. ICCNMC 2005 allowed sharing of the underlying theories and applications, and the establishment of new and long-term collaborative channels aimed at developing innovative concepts and solutions geared to future markets. The highly positive response to ICCNMC 2001 and ICCNMC 2003, held in Beijing and Shanghai, respectively, encouraged us to continue this international event. In its third year, ICCNMC 2005 continued to provide a forum for researchers, professionals, and industrial practitioners from around the world to report on new advances in computer network and mobile computing, as well as to identify issues and directions for research and development in the new era of evolving technologies.
Network and Parallel Computing ; IFIP International Conference, NPC 2005, Beijing, China, November 30 - December 3, 2005, Proceedings
These proceedings contain the papers presented at the 2005 IFIP International Conference on Network and Parallel Computing (NPC 2005), held in Beijing, China, between November 30 and December 3, 2005. The goal of the conference was to establish an international forum for engineers and scientists to present their ideas and experiences in network and parallel computing. A total of 320 submissions were received in response to our Call for Papers. These papers were from the following countries or regions: Australia, Canada, China, France, Germany, Hong Kong, India, Iran, Italy, Japan, Korea, Lux- burg, Nepal, Netherlands, Taiwan, United Arab Emirates, and United States.
Neonatal Immunity
New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
Natural Resistance Mechanisms of Plants to Viruses
Resistance phenomena such as the local lesion response, induced resistance, "green islands" and resistance in various crop plants are linked with new information on gene-silencing mechanisms, gene silencing suppressors, movement proteins and plasmodesmatal gating, downstream signalling components, and more.
Multi-Agent Programming : Languages, Platforms and Applications
Part I describes four approaches that are based on computational logic or process algebra--Jason, 3APL, IMPACT, and CLAIM/SyMPA. These programming languages have formal semantics and use heavy machinery based on formal methods, but also provide working platforms for the development of multi-agent systems. Part II presents agent languages and platforms that extend or are based on Java--JADE, Jadex, and JACKTM. Although these have no formal semantics, the languages are well documented and the platforms provide a variety of tools that have been extensively used in practice. Part III provides two significant industry specific applications--The DEFACTO System for coordinating human-agent teams for the future of disaster response, and the ARTIMIS rational dialogue agent technology. The book also features seven appendices, summarising each of the agent programming languages, hence facilitating comparison of the approaches. In particular, Appendix A describes the criteria used for comparing the agent languages and platforms.
Move : Architecture in Motion - Dynamic Components and Elements
Dynamic components and adaptive elements are becoming increasingly important in contemporary architecture, and not just because of their visual effect. If architects and engineers are engaging more and more with the issue of movement – whether in the form of sun-tracking solar cells, lowerable walls, or intelligently programmed elevators – it’s because they are busy exploring responses to three challenges: How can we control and reduce the energy requirement of buildings? How can we expand the range of possible uses? And how can we represent, illustrate, accommodate, and control dynamic movements in buildings?
