الصفحة 1
الصفحة 1
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
Oculoplastics and Orbit
Considerable progress has been made in various fields of oculoplastic surgery, e.g. the development of endoscopic transcanalicular as well as endonasal minimal invasive techniques in lacrimal surgery, the use of muscle pedunculated scleral flaps to improve implant motility without pegging. This extraordinary volume enhances your understanding of Graves’ ophthalmopathy and helps you to define situations suitable for radiotherapy and more differentiated surgical strategies such as orbital fat resection, balance bony decompression and lid lengthening procedures. It exemplifies progress in aesthetic surgery such as endoscopic brow lift and soft techniques for mid-face rejuvenation and discusses general risks of infectious disease transmission using allografts as well as current concepts in the management of conjunctival neoplasms.
New Vision of Metformin in treating cancer
The anti-diabetic drug metformin is rapidly emerging as a potential anticancer agent. Metformin is a biguanide that is effective in treating type 2 diabetes and the insulin resistance syndromes, improves insulin resistance by reducing hepatic gluconeogensis and by enhancing glucose uptake by skeletal muscle. Metformin can reduce the incidence of cancers and can reduce the mortality from cancers, increase the response to treatment cancer cells when using radiotherapy and chemotherapy, reduce the likelihood of relapse. Diabetes can be a factor in the occurrence of various types of cancer, and develop a variety of cancers such as colo-rectal, pancreas and liver cancers, compared to non-diabetic patients. Incidence of various cancers is high among patients of T2DM due to insulin resistance and mitogenic effects caused by hyperglycemia.
New Technologies in Radiation Oncology
This book provides an overview of recent advances in radiation oncology, many of which have originated from physics and engineering sciences. After an introductory section on basic aspects of 3D medical imaging, the role of 3D imaging in the context of radiotherapy is explored in a series of chapters on the various modern imaging techniques. A further major section addresses 3D treatment planning for conformal radiotherapy, with consideration of both external radiotherapy and brachytherapy. Subsequently the modern techniques of 3D conformal radiotherapy are described, including stereotactic radiotherapy, intensity-modulated radiation therapy, image-guided and adaptive radiotherapy, and radiotherapy with charged particles. More clinically oriented chapters explore the use of brachytherapy in patients with prostate cancer, cardiovascular disorders and breast cancer. The book concludes with a section on quality assurance.
Methods of Cancer Diagnosis, Therapy and Prognosis : Breast Carcinoma
Focusing on Breast Carcinoma, this first volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis brings together 56 leading scientists from around the world to deliver a comprehensive treatise on all aspects of breast cancer, including diagnosis, treatments and prognosis.
Metastasis of Prostate Cancer
Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible.
Métastases vertébrales = Vertebral metastases
Updating the technical progress made by each of the players, both diagnostic and therapeutic, was necessary and confirms the quality of the result of a joint venture serving a patient in a particularly delicate situation. It is intended to be practical for each of the care providers and didactic for those who are less specialized in one or another area. This has led us to make choices, of course debatable, leading to explanations that are sometimes a little too "obvious" for connoisseurs, a little too technical for neophytes, repetitions for everyone to find in "their" chapter what makes it so. interested.
Medical image synthesis : Methods and clinical applications
Image synthesis across and within medical imaging modalities is an active area of research with broad applications in radiology and radiation oncology. This book covers the principles and methods of medical image synthesis, along with state-of-the-art research. First, various traditional non-learning-based, traditional machine-learning-based, and recent deep-learning-based medical image synthesis methods are reviewed. Second, specific applications of different inter- and intra-modality image synthesis tasks and of synthetic image-aided segmentation and registration are introduced and summarized, listing and highlighting the proposed methods, study designs, and reported performances with the related clinical applications of representative studies. Third, the clinical usages of medical image synthesis, such as treatment planning and image-guided adaptive radiotherapy, are discussed. Last, the limitations and current challenges of various medical synthesis applications are explored, along with future trends and potential solutions to solve these difficulties.
Hyperthermia In Cancer Treatment : A Primer
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
Head and neck cancer recurrence : Evidence-based, multidisciplinary management
The first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and function.
Global optimization ; Vol. 85 : Scientific and engineering case studies
Optimization models based on a nonlinear systems description often possess multiple local optima. The objective of global optimization (GO) is to find the best possible solution of multiextremal problems. Global Optimization: Selected Case Studies illustrates the applicability of GO modeling techniques and solution strategies to real-world problems.The contributed chapters cover a broad range of applications from agroecosystem management, assembly line design, bioinformatics, biophysics, black box systems optimization, cellular mobile network design, chemical process optimization, chemical product design, composite structure design, computational modeling of atomic and molecular structures, controller design for induction motors, electrical engineering design, feeding strategies in animal husbandry, the inverse position problem in kinematics, laser design, learning in neural nets, mechanical engineering design, numerical solution of equations, radiotherapy planning, robot design, and satellite data analysis. The solution strategies discussed encompass a range of practically viable methods, including both theoretically rigorous and heuristic approaches.
Free-Radical-Induced DNA Damage and Its Repair : A Chemical Perspective
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
Facts about the most three common types of cancer in Syria
Cancer occurs when the cellular reproduction process goes out of control. In other words, cancer is a disease characterized by uncontrolled, uncoordinated and undesirable cell division. Unlike normal cells, cancer cells continue to grow and divide for their whole lives, replicating into more and more harmful cells. But death rates are falling, thanks to earlier detection of tumours and improved use of existing treatments - mainly chemotherapy biological therapy and radiotherapy. And today Our research tends to spot the light on the most common types of cancers in Syria which was found to be lung cancer, colorectal cancer, and breast cancer.
Evidence based practice in Neuro-oncology
This book provides evidence-based management in neuro-oncology covering all aspects such as pathology, radiology, surgery, radiation, and chemotherapy.The field of neuro-oncology is rapidly evolving and new evidence is coming out every day towards the optimal management of brain tumors. This necessitates a requirement of a complete guide that shall provide an evidence-based and personalized approach towards dealing with patients. This book also covers recent advances in personalized treatment formed through the relevant basis of anatomy, imaging, radiology, surgical, radiation and systemic treatment of brain and spinal tumors. In addition it also covers the , practical aspects of the planning of the Gamma knife and other radio surgical aspects.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology
Dynamic contrast-enhanced MRI is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. This is assisting clinical practitioners in the management of patients with solid tumors and is finding prominence in the assessment of tumor treatments, including anti-angiogenics, chemotherapy, and radiotherapy. In this book, targeted at both clinical practitioners and basic scientists, the principles of the methods, their practical implementation, and their application to specific tumor types are discussed by the leading authorities in the field today. The book will serve as an invaluable single-volume reference covering all the latest developments in contrast-enhanced oncological MRI.
Cured II - LENT Cancer Survivorship Research and Education : Late Effects on Normal Tissues
Multimodal treatment lies at the heart of the improvement in cancer cure rates. However, the more aggressive the treatment delivery in terms of dose, time and volume for radiation and chemotherapy, the more adverse effects in normal tissues can be anticipated. Against this background, a major paradigm shift has taken place in that there is a new focus on cancer survivorship. Put another way, there has been a realization that prolongation of life must be accompanied by maintenance of the quality of life: the life worth saving must be worth living.
Critical Issues in Head and Neck Oncology : Key Concepts from the Seventh THNO Meeting
This book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers
Management of Early Stage Breast Cancer : Basics and Controversies
Breast cancer, its causes, early detection and treatment have received considerable attention, since this widespread disease is one of the most important health concerns for women. This book provides a comprehensive overview of the diagnostic and therapeutic aspects of the management of early-stage breast cancer, including essential information on basic topics like pathology, and radiology, as well as the latest developments. Further, it discusses all aspects of surgical care, chemotherapy and radiation therapy, together with the controversies and current management guidelines.
Machine learning for biomedical application
Biomedicine is a multidisciplinary branch of medical science that consists of many scientific disciplines, e.g., biology, biotechnology, bioinformatics, and genetics; moreover, it covers various medical specialties. In recent years, this field of science has developed rapidly. This means that a large amount of data has been generated, due to (among other reasons) the processing, analysis, and recognition of a wide range of biomedical signals and images obtained through increasingly advanced medical imaging devices. The analysis of these data requires the use of advanced IT methods, which include those related to the use of artificial intelligence, and in particular machine learning. It is a summary of the Special Issue “Machine Learning for Biomedical Application”, briefly outlining selected applications of machine learning in the processing, analysis, and recognition of biomedical data, mostly regarding biosignals and medical images.
Liver Radioembolization with Y90 Microspheres
Provides an in-depth account of all aspects of radioembolization, a relatively novel technique based on the efficacy of radiotherapy for the treatment of liver tumors.
