الصفحة 1
الصفحة 1
On the path to AI : Law’s prophecies and the conceptual foundations of the machine learning age
This book explores machine learning and its impact on how we make sense of the world. It does so by bringing together two ‘revolutions’ in a surprising analogy: the revolution of machine learning, which has placed computing on the path to artificial intelligence, and the revolution in thinking about the law that was spurred by Oliver Wendell Holmes Jr in the last two decades of the 19th century.
On Line Citizenship : Emerging Technologies for European Cities
The book presents e-government issues from an institutional as well as a practical point of view through the contributions of distinguished authors representative of the European Union, the European network of cities (Telecities) and the Italian Government. On Line Citizenship offers an innovative approach in the analysis of technology's evolutionary paths in e-government through a comparison with e-business trends.
Office and SharePoint 2007 User’s Guide : Integrating SharePoint with Excel, Outlook, Access, and Word
Web sites. Collaboration. Document management. Paperless offices. We want it all in business today, but how do you achieve all of these goals? More importantly, if you work for one of the millions of small to medium–sized businesses, how do you find the time and build the expertise necessary to reach these goals? Even the most powerful tool will not allow you to succeed unless you can get the majority of your staff to use it efficiently and effectively. You need a guide that demonstrates a platform small to medium–sized businesses can use to reach these goals.
Oculoplastics and Orbit
Considerable progress has been made in various fields of oculoplastic surgery, e.g. the development of endoscopic transcanalicular as well as endonasal minimal invasive techniques in lacrimal surgery, the use of muscle pedunculated scleral flaps to improve implant motility without pegging. This extraordinary volume enhances your understanding of Graves’ ophthalmopathy and helps you to define situations suitable for radiotherapy and more differentiated surgical strategies such as orbital fat resection, balance bony decompression and lid lengthening procedures. It exemplifies progress in aesthetic surgery such as endoscopic brow lift and soft techniques for mid-face rejuvenation and discusses general risks of infectious disease transmission using allografts as well as current concepts in the management of conjunctival neoplasms.
Oculoplastics and Orbit
This book have been provided throughout each chapter. evidence-based medicine into clinical practice.It is reasonable to now update our With the start of the second cycle of subspecialty readers with what has been achieved. coverage, the dissemination of practical inform- a Te immediate goal was to transfer inform- a tion will be continued as we learn more about tion through a high quality quarterly publication the emerging advances in various ophthalmic in which ophthalmology would be represented by subspecialties that can be applied to obtain the eight subspecialties.
Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Ocular Angiogenesis : Diseases, Mechanisms, and Therapeutics
Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches. Comprehensive and multidisciplinary, Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics offers a novel view of the clinical features of pathological angiogenesis in the eye, the molecular and environmental switches that govern vessel growth, and the tremendous opportunities for and progress made in the development of new therapeutics.
Oceans and Health: Pathogens in the Marine Environment
The importance of combating infectious diseases has received international attention, p- viding the opportunity for a multidisciplinary approach that combines medicine with other scientist candtechnological capabilities,notably information technology,nanotechnology,and biotechnology. In fact, it has been predicted that the future will bring a merging of these te- nologies with the cognitive and behavioral sciences.. The connection between infectious diseases and the oceans provides a paradigm for this perspective. A stark global context indisputably frames all human health issues in the twenty century: the world wide movement of people and goods. Throughout the past half century, international travel has skyrocketed; there are more than 500 million international arrivals per year. The greatest increase has taken place since the mid-1990s. The world has become integrated and global; consequently, the notion that it is possible to successfully eradicate a disease from the face of the planet has become simplistic. Infectious disease is a moving target and climate shifts will affect any disease that has an environmentally sensitive stage or vector.
Occlusal splints for painful craniomandibular dysfunction
Bridges that gap, presenting a practical guide for the treatment of craniomandibular dysfunction (CMD)—a functional disorder that affects the muscles of mastication, temporomandibular joints, and/or occlusion—in patients with related pain. The first half of the book provides detailed but simple clinical instructions and examples of occlusal splint therapy, including splint fabrication and coordinative training for painful CMD, based entirely on a high level of evidence. The second half delves deeper into the etiology, advanced diagnostic techniques, neurobiology, and pathophysiology of painful CMD and splint therapy.
Object-oriented metrics in practice : Using software metrics to characterize, Evaluate, and Improve the design of object-oriented systems
The combination of theoretically sound results and practically tested procedures and solution paths makes this book an ideal companion for professional software architects, developers and quality engineers. The pattern-oriented description of disharmonies offers easy access to detecting shortcomings and applying solution strategies. "This well-written book is an important piece of work that takes the seemingly forgotten art of object-oriented metrics to the next level in terms of relevance and usefulness."
Obesity and Cancer
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development.
Nutritional psychiatry
Provides a comprehensive overview of nutritional psychiatry, elucidating its theoretical foundations, the biological mechanisms linking diet to mental health (including inflammation, oxidative stress, disrupted energy metabolism the gut–brain axis and other implicated pathways), and the current evidence base for dietary impacts on major psychiatric disorders such as depression, anxiety, schizophrenia, bipolar disorder, and ADHD.
Nutrition and Rheumatic Disease
It is difficult, if not impossible, for health care providers to remain at the forefront of knowledge for all aspects of nutrition and rheumatic diseases. In Nutrition and Rheumatic Disease, experts provide a comprehensive review of current knowledge regarding nutrition and dietary management for the complex set of rheumatic conditions. Within the disease-specific chapters, the authors present a historical perspective, a discussion of the major clinical features, current management and treatment, a review of the literature related to nutritional status and diet, and dietary recommendations, based on current scientific evidence. The field of rheumatic diseases includes a wide variety of pathologic processes. Adequate reviews of the scientific literature on each of the rheumatic diseases in Nutrition and Rheumatic Disease alleviate the inherent confusion surrounding the risks and benefits of various dietary therapies.
Nursing Care of the Pediatric Neurosurgery Patient
Nursing Care of the Pediatric Neurosurgery Patient serves as a detailed reference for all nurses caring for children with neurosurgical problems. Staff nurses (and student nurses) working in clinics, PICU, pediatrics, operating rooms, post-anesthesia care units, emergency department and radiology will benefit from the information presented in this book. The explanations of pathophysiology, anatomy, radiodiagnostic testing and treatment options for each neurosurgical diagnosis will help them to understand the rationale behind the nursing care. Presenting symptoms and findings on neurological examination and history will enable nurses to identify normal signs. Each chapter includes information on patient and family education and will give helpful guidelines.
Numerical Continuation Methods for Dynamical Systems : Path following and boundary value problems
The book opens with a foreword by Herbert B. Keller and lecture notes by Sebius Doedel himself that introduce the basic concepts of numerical bifurcation analysis. The other chapters by leading experts discuss continuation for various types of systems and objects and showcase examples of how numerical bifurcation analysis can be used in concrete applications. Topics that are treated include: interactive continuation tools, higher-dimensional continuation, the computation of invariant manifolds, and continuation techniques for slow-fast systems, for symmetric Hamiltonian systems, for spatially extended systems and for systems with delay. Three chapters review physical applications: the dynamics of a SQUID, global bifurcations in laser systems, and dynamics and bifurcations in electronic circuits.
Nuclear pre-mRNA Processing in Plants
In recent years nuclear pre-mRNA processing has taken center stage as an important regulator of gene expression and ultimately growth and development. Large-scale genome and cDNA sequencing projects together with bioinformatic analyses of these sequences have revealed that alternative splicing of pre-mRNAs contributes greatly to transcriptome and proteome complexity in eukaryotes. During the last few years, tremendous progress has been made in understanding various aspects of pre-mRNA processing including alternative splicing and its importance in plant growth and development as well as in plant responses to hormones and stresses. This book, with contributions from leading scientists in this area, summarizes recent advances in nuclear pre-mRNA processing in plants. It provides researchers in the field, as well as those in related areas, with an up-to-date and comprehensive, yet concise, overview of the current status and future potential of this research in understanding plant biology.
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Novel mouse model for future autism research
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the first 3 years of life. It is not a single disorder, and it is broadly considered to be a multi-factorial disorder resulting from genetic and non-genetic risk factors and their interaction. Genetic studies of ASD have identified mutations that interfere with typical neurodevelopment in utero through childhood. These complexes of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have provided many important insights into the pathological changes that occur in the brain of patients with ASD in vivo. Especially, the role of amygdala, a major component of the limbic system and the affective loop of the cortico-striatothalamo-cortical circuit, in cognition and ASD has been proved in numerous neuropathological and neuroimaging studies.
Novel food grade enzymes : Applications in food processing and preservation industries
Covers all the aspects of food-grade enzymes, including their classification, kinetics, microbial production, biosynthetic pathways, commodity-wise industrial applications, and downstream processing strategies. The broad focus of this book is on the application of various classes of enzymes in dairy, fruits and vegetables, cereals and oilseeds, meat and poultry, and brewing and food packaging industries. Certain recent areas such as nanotechnological perspective in enzyme immobilization, infusion strategies as well as its efficient usage in food packaging and preservation are some of the salient highlights of this book. This book also discusses the aspects related to application of enzymes in functional food development and shelf life extension of various commodities food products.
Novel Biotechnologies for Biocontrol Agent Enhancement and Management
This multidisciplinary group, having backgrounds in the diff- ent aspects of biotechnologies (transgenic enhancement, molecular biology, formulation, genetics, risk assessment, new technology, biochemistry, and physiology), presented highly advanced lectures during the 10-day-ASI, in order to allow students to improve their capability to enhance and manage - ological control agents. This approach will allow ASI attendees to bring new ideas, new approaches, or new methodologies coming from different ?elds of application to their own ?eld of expertise.
