الصفحة 1
الصفحة 1
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting
ompiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes
Nimesulide - Actions and Uses
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs.
Neutrophil : Methods and Protocols
Neutrophils, the most abundant white cells in humans, serve as the primary cellular defense against infection. This volume provides a concise set of protocols for assessing basic neutrophil functions and investigating specialized areas in neutrophil biology. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. Part I contains overviews of neutrophil biology, function, and disorders. Part II describes commonly used methods to isolate neutrophils from humans and other animal species. Part III details methods for investigating chemotaxis, transmigration, phagocytosis, and bactericidal activity. Part IV includes protocols that measure neutrophil apoptosis, calcium signal transduction, degranulation and detection of cytoplasmic granules, gene expression, transcription factors, and apoptosis. Part V provides multiple assays for measuring production of intracellular and/or extracellular reactive oxygen species, and a method that details use of the cell-free NADPH oxidase assay, an iconic assay for studies of the neutrophil NADPH oxidase. Part VI provides chapters that describe how to analyze formation and function of neutrophil extracellular traps.
Natural Products Targeting Clinically Relevant Enzymes
Covers the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Nanotechnology for Environmental Remediation
The newly discovered advanced oxidation technology using nanoscale zero-valent iron, which is reported in this book, could be widely used to treat pesticides, herbicides, and industrial chemicals as well as to purify contaminated water for domestic use. In addition, it can contribute to advancing science and technology and providing valuable information to all readers - researchers, scientists, engineers, and students - in this field for their further research and studies.
Mud and Mudstones : Introduction and Overview
Our book provides the first elementary overview of mud and mudstone written for a broad spectrum of professionals, teachers and students in geology, petroleum geology and engineering, urban planning and development, paleontology and paleoecology, and architecture and archaeology. Mud and mudstone provide the foundations to master all their aspects and prepares you to dig deeply into the many fascinating questions of their origin, relationships to earth history and practical uses. Key topics include the production of mud, its transport, the important role of bottom oxygen, sites of deposition, burial, provenance, mudstones in basins and an overview of practical uses followed by an appendix and extended glossary.
Modern treatments for chronic blood diseases
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloida osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). Thalassemias are inherited blood disorders characterized by decreased hemoglobin production Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
Inflammation in the Pathogenesis of Chronic Diseases : The COX-2 Controversy
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors.
Homocysteine
Homocysteine is a non-proteinogenic α-amino acid. It is a homologue of the amino acid cysteine, differing by an additional methylene bridge (-CH2-). It is biosynthesized from methionine by the removal of its terminal methyl group. In the body, Homocysteine (HCY) can be recycled into methionine or converted into cysteine with the aid of certain B-vitamins. A high level of Homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, which leads to inflammation in the blood vessels, which in turn may lead to atherogenesis, which can result in ischemic injury. Therefore, hyperhomocysteinemia is a possible risk factor for coronary artery disease (CAD). Coronary artery disease occurs when an atherosclerotic plaque blocks blood flow to the coronary arteries, which supply the heart with oxygenated blood.
Home Long-Term Oxygen Treatment in Italy : The Additional Value of Telemedicine
This book, edited by Roberto W. Dal Negro and Allen I. Goldberg, gives us a full account of the impact of the telemedicine system on H-LTOT. According to the information in this book, we have to begin to think about the possibility of using telemonitoring in H-LTOT in a really general manner. In fact, telemonitoring allows better control of the compliance of patients suffering from respiratory failure, and this means a better clinical condition and longer survival, both linked to the long-term administration of oxygen. Moreover, it also permits a reduction in expenditure for the management of patients under LTOT.
High Thermal Conductivity Materials
High thermal conductivity materials play an important role in addressing thermal management issues. This volume provides readers a basic understanding of the thermal conduction mechanisms in these materials and discusses how the thermal conductivity may be related to their crystal structures as well as microstructures developed as a result of their processing history. The techniques for accurate measurement of these properties on large as well as small scales have been reviewed. Detailed information on the thermal conductivity of diverse materials including aluminum nitride (AlN), silicon carbide (SiC), diamond, as well as carbon nanotubes has been presented. The emphasis is on developing basic understanding of the inter-relationships between thermal conductivity and processing such that the readers can conduct their own research in this exciting field of high thermal conductivity materials.
Handbook on Hyperbaric Medicine
It is now ten years since the first Handbook on Hyperbaric Medicine was published. During this time there have been many major advances: our understanding of the actions of hyperbaric oxygenation, and the pathophysiological processes it engages, have been elucidated by several studies; clinical practice is becoming more scientific with the application of evidence-based medicine (EBM) principles and the appearance of a number of randomised clinical trials; various consensus-derived organisational and operational recommendations and guidelines have become normative and are now widely accepted.
Fuel Oxygenates
purpose of this series on Environmental Chemistrytherefore, is to present a reasonably uniform view of various aspects of the chemistry of the environment and chemical reactions occurring in the environment. The industrial activities of man have given a new dimension to Envir- mental Chemistry. We have now synthesized and described over ?ve million chemical compounds and chemical industry produces about hundred and ?fty million tons of synthetic chemicals annually. We ship billions of tons of oil per year and through mining operations and other geophysical modi?cations, large quantities of inorganic and organic materials are released from their natural deposits.
Ferro- and Antiferroelectricity : Order/Disorder versus Displacive
Solid-state systems are frequently classi?ed according to their physical, str- tural or chemical properties. Such schemes are extremely helpful since pr- erties related to any such classi?cation are typically known and facilitate id- tifying solids with special material classes. The best-known examples of these schemes are conductivity or resistivity measurements by means of which m- als are easily distinguishable from insulators. However, frequently clear-cut decisions between material classes are not possible, since anisotropy, chemical composition, binding forces and local effects wash out distinct properties and lead to competition or coexistence. Such unresolved situations are especially typical for transition metal oxides that exhibit a variety of ground-state properties in a fascinating way.
Facilitative glucose transporters in articular chondrocytes : Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory Cytokines
In this multidisciplinary article we review the molecular and morphological aspects of GLUT expression and function in chondrocytes and their mesenchymal and embryonic stem cell precursors and propose key roles for these proteins in glucose sensing and metabolic regulation in cartilage.
Essays in Brewing Science
Essays in Brewing Science is an original and comprehensive examination of brewing from the perspective of a real brewer. Brewing texts generally use a sequential barley-beer-bottle organization that takes the reader systematically through the various stages of beer-making in a logical and informative way. This approach adequately communicates the essential operation. However, brewers think about all of the stages in the process that might affect a single property, such as beer color. Alternatively brewers might ponder the influence of such affective agents as modification or oxygen throughout the process.
Engineering and health in compressed air work : Proceedings of the 2nd International conference on engineering and health in compressed air Work held at St Catherine's College, Oxford, from 25th to 27th September, 2002
Presents the proceedings of theSecond International Conference on Engineering and Health in Compressed Air Work, Heald at St Catherine's College, Oxford from 25th to 27th September 2002. The 35 papers in this volume cover a range of subjects, including experience with oxygen decompressionnin the UK and research related tothe introduction of oxygen decompression, which will be of interest to everyone involved with the engineering, medical or regulatory aspects of compressed air working and all those with an interest in hyperbaric exposure.
Dioxygen Binding and Sensing Proteins : A Tribute to Beatrice and Jonathan Wittenberg
Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments.This book is dedicated to Jonathan’s and Bea’s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
Diabetes genetic finder & predictor = أداة البحث والتنبؤ الجيني لمرض السكري
The diabetes genetic finder & predictor app is a comprehensive, user-friendly solution that revolutionizes diabetes care. This powerful app integrates a wide array of features designed to empower diabetes patients and enhance their overall well-being. A standout feature of the app is its ability to predict the risk of hereditary diabetes diseases, offering users early detection and intervention opportunities. It also predicts general diabetes risk, diabetic foot complications, and retinopathy. Users can monitor their blood sugar levels, heart rate, and oxygenation either manually or through smart watch integration. Additionally, users can enter their diabetes type and HbA1c levels.The app's medication management feature simplifies the complex task of tracking and organizing medications, providing timely reminders to ensure adherence to treatment plans. Users can scan QR codes on products to check their sugar content and suitability, schedule their medications, generate reports for specific periods, and access a comprehensive list of frequently asked questions about diabetes..
