الصفحة 1
الصفحة 1
Morphology, Molecules, Evolution and Phylogeny in Polychaeta and Related Taxa; Proceedings of two ISSI Workshops, 18–22 October 1999 and 15–19 May 2000, Bern, Switzerland
Recently, evidence has been accumulated which shows that some of the groups formerly regarded as independent "phyla" such as Pogonophora (now recognized as Siboglinidae), Echiura, Myzostomida and perhaps Sipuncula, are most probably nothing else than greatly modified Annelida. The extreme morphological diversity found especially in Polychaeta displays the plasticity of a simple segmented organisation that basically is nothing else but a serial repetition of identical units. Thus, annelids are highly important to our understanding of fundamental questions about morphological and adaptive diversity, as well as clarifying evolutionary changes and phylogenetic relationships. The book aims to summarize our knowledge on Polychaetes polychaetes and their allies and gives an overview of recent advances gained by studies that employed conventional and modern methods plus, increasingly and importantly, the use of molecular markers and computer-assisted kinship analyses. It also reflects the state of art in polychaete sciences and presents new questions and controversies. As such it will significantly influence the direction of research on Polychaeta and their related taxa.
Molecular Pathology of Gynecologic Cancer
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients.
Molecular Markers of Brain Tumor Cells : Implications for Diagnosis, Prognosis and Anti-Neoplastic Biological Therapy
Childhood brain tumors are a diverse group of diseases characterized by the abnormal growth of tissue contained within the skull. Other than leukemia and lymphoma, brain tumors are the most common type of neoplasms that occur in children. The leading cause of death from childhood neoplasms among persons up to 19 years is brain tumors. As such, this book is a review of the most recent molecular biological research concerning brain tumors with references and comparisons to a variety of neoplastic disorders. The book then uses this information to foreshadow the direction that future anti-neoplastic therapies will take. Because of the wide spectrum of the objectives of the book, any individual involved in cancer research will greatly benefit from the work. Histopathologists, neuropathologists, clinical and research oncologists, and medical students will find this book to be an invaluable resource as a reference guide. Patients and their families will also find the book useful as it offers a comprehensive update on new, non-classical therapeutic modality options and contains a detailed description and analysis of brain tumors. Such an endeavor has yet to be undertaken by any other book and may prove to be the most comprehensive book on brain tumors thus far.
Molecular Marker Systems in Plant Breeding and Crop Improvement
Successful release of new and better crop varieties increasingly requires genomics and molecular biology. This volume presents basic information on plant molecular marker techniques from marker location up to gene cloning. The text includes a description of technical approaches in genome analysis such as comparison of marker systems, positional cloning, and array techniques in 19 crop plants. A special section focuses on converting this knowledge into general and specific breeding strategies, particularly in relation to biotic stress. Theory and practice of marker assisted selection for QTL, gene pyramiding and the future of MAS are summarized and discussed for maize, wheat, and soybean. Furthermore, approaches in silviculture on the examples of Fagus, Populus, Eucalyptus, Picea and Abies are presented. The volume ends with a comprehensive review of the patents relevant for using molecular markers and marker assisted selection.
Metastasis of Prostate Cancer
Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible.
Infections à papillomavirus : État des connaissances, pratiques et prévention vaccinale = Human papillomavirus infections : Current knowledge, practices and vaccination prevention
The impact of papillomavirus (HPV) infection is considerable. More than one in two women has been exposed to HPV in her lifetime and around 10% will develop a chronic infection. Of these, 20% will develop cervical cancer in the absence or failure of screening. In France, high-risk HPV infection causes 80,000 precancerous lesions, 3,400 cervical cancers and the death of 1,000 women every year. Smear screening performed at a regular rate and according to quality standards has resulted in a significant decrease in incidence and mortality over the past 20 years. However, despite this considerable success, the so-called preventable disease has not been eradicated; testing is a complex process that only benefits part of the population while those who benefit endure its weaknesses. Optimization of screening and treatment is now made possible by the use of innovative techniques including the smear in liquid suspension, the HPV test, and soon viral genotyping and molecular markers guaranteeing maximum protection. Because cervical cancer is the result of chronic HPV infection, we already have the extraordinary chance to prevent it with a prophylactic vaccine. This progress will have a major impact on our practices as it happens in a poorly prepared medico-sociological environment. This resolutely practical and educational book provides an overview of knowledge and perspectives on HPV infection and its associated pathologies while deciphering the new challenges and practices in the vaccine era.
High-Grade Gliomas : Diagnosis and Treatment
This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response.
Genomics of Tropical Crop Plants
Genomics of Tropical Crop Plants summarizes recent progress on genomic research, including the development of molecular markers, genomic and cDNA libraries, expressed sequence tags (ESTs), genetic and physical maps, gene expression profiles, and whole genome sequences for 20 tropical crop plants. It offers background information about the evolutionary origin and environments of tropical crop species, international programs that are addressing the needs of tropical agriculture, and the potential for new technologies to increase the productivity and value of tropical crops. This book provides new dimensions to growing information concerning temperate crops and their morphology, physiology, and parallel evolution in diverse plant lineages.
