الصفحة 1
الصفحة 1
Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Ocular Angiogenesis : Diseases, Mechanisms, and Therapeutics
Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches. Comprehensive and multidisciplinary, Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics offers a novel view of the clinical features of pathological angiogenesis in the eye, the molecular and environmental switches that govern vessel growth, and the tremendous opportunities for and progress made in the development of new therapeutics.
Ocean-atmosphere interactions of gases and particles
The oceans and atmosphere interact through various processes, including the transfer of momentum, heat, gases and particles. In this book leading international experts come together to provide a state-of-the-art account of these exchanges and their role in the Earth-system, with particular focus on gases and particles. Chapters in the book cover: i) the ocean-atmosphere exchange of short-lived trace gases; ii) mechanisms and models of interfacial exchange (including transfer velocity parameterisations); iii) ocean-atmosphere exchange of the greenhouse gases carbon dioxide, methane and nitrous oxide; iv) ocean atmosphere exchange of particles and v) current and future data collection and synthesis efforts.
Object Recognition, Attention, and Action
This book provides an excellent introduction to the issues that are involved, with chapters that address the ways in which humans and machines attend to, recognize, and act toward objects in the visual environment.
Nutritional psychiatry
Provides a comprehensive overview of nutritional psychiatry, elucidating its theoretical foundations, the biological mechanisms linking diet to mental health (including inflammation, oxidative stress, disrupted energy metabolism the gut–brain axis and other implicated pathways), and the current evidence base for dietary impacts on major psychiatric disorders such as depression, anxiety, schizophrenia, bipolar disorder, and ADHD.
Nutrient Acquisition by Plants : An Ecological Perspective
Adaptation and evolution of terrestrial plants depend, to a large extent, on their ability to acquire nutrients. This is a modern and integrative treatment of the mechanisms controlling plant nutrient uptake and how plants respond to changes in the environment. The following key topics are covered: soil nutrient bioavailability; root responses to variations in nutrient supply; nitrogen fixation; regulation of nutrient uptake by internal plant demand; root characteristics; kinetics of nutrient uptake; root architecture; life span; mycorrhizae; responses to climate change. This integrated view helps us to understand the mechanisms that govern present-day plant communities and is indispensable in models designed to predict the response of plants to a changing climate.
Nutraceuticals in obesity management and control
Provides detailed information on nutraceuticals that can be helpful in the control and management of obesity. It clarifies key aspects of nutraceuticals that include sources, extraction, chemistry, mechanisms of action, pharmacology, bioavailability, safety, and various applications. Beginning with a concise overview of the prevalence of obesity, complications related to obesity, and current treatment regimens, the volume delves into the roles of functional foods and nutraceuticals for the management of body weight and for alleviating obesity comorbidities. It goes on to discuss the effect of some of the most commonly and frequently used naturally occurring nutraceutical substances, along with their mechanisms of action in controlling obesity. The volume looks at the role of nutraceutical fruits as well as the beneficial aspects of carotenoids in fruits and vegetables and explores antioxidant-rich nutraceuticals, the role of vitamins and supplements, the use of green tea, and the potential of pseudocereals and spices in the management of metabolic syndrome.
Nutraceuticals in cardiac health management
Cardiovascular diseases (CVDs) constitute the major cause of death worldwide, claiming nearly 18 million lives each year. Multiple foods and nutraceuticals have been proven to reduce the risk of cardiovascular disease. This new book offers an informative update on the most recent scientific evidence addressing the use of nutraceuticals in the prevention and management of heart disease. It summarizes the functional foods that are involved in preventing the risk of CVDs, the mechanisms of the bioactive components that lower the risk of chronic illnesses, as well as the dietary patterns that are involved in the prevention of CVDs. It also covers specific nutraceuticals, including probiotics, dietary fibers, garlic, green tea, vitamins, tomatoes and other lycopene-rich fruits and vegetables, dietary supplements, bee products, and more. In addition, it focuses on detailing the endothelial effects of marine- and plant-derived omega-3 fatty acids and marine-derived natural flavonoids in hypertension and CVDs.
Nutraceuticals and obesity strategies for weight management
his comprehensive volume explores the role that nutraceuticals can play in addressing obesity, shedding light on their potential as tools to promote sustainable weight management strategies as well as addressing associated health risks. Delving into the intricate interplay between nutrition, health, and obesity, the book provides a compelling account that illustrates how nutraceutical interventions can be incorporated into holistic obesity management strategies. It begins with an account of the mechanisms by which nutraceuticals function before featuring chapters on their efficacy and safety, how they can be integrated with other therapeutic interventions, and how they can be tailored for individuals with comorbidities. Offering a global perspective on the issue, there is also coverage of the various regulatory contexts in which nutraceuticals are sold and used.
Nutraceuticals and health care ; 1st ed.
Explores the role of plant-based nutraceuticals as food ingredients and as therapeutic agents for preventing various diseases. The book assesses the role of nutraceuticals in addressing cardiovascular disease, cancer, diabetes, and obesity by highlighting the derivatives, extraction, chemistry, mechanism of action, pharmacology, bioavailability, and safety of specific nutraceuticals. It analyzes twenty one nutraceuticals in a systematic way, providing a welcomed reference for nutrition researchers, nutritionists and dieticians, as well as other scientists studying related areas in food science, technology or agriculture. Students studying related topics will also benefit from this material.
Nutraceuticals and bone health
Here is an informative volume on the importance of nutraceuticals and herbal remedies for bone health. It explains the probable mechanisms of nutraceuticals for the prevention, treatment, and management of bone-related diseases as well as their curable effects on bone injuries. The volume covers the progression and development of bones, which is a multifaceted process that requires an endless and ample supply of nutrients, such as calcium, phosphorus, potassium, protein, vitamin D, magnesium, and fluoride. The book delves into the beneficial effects of nutraceuticals on overall bone health and for the treatment of bone disorders such as osteoporosis, bone fractures, scoliosis and related complications, rheumatoid arthritis, Paget’s disease, bursitis, gout, and carpal tunnel syndrome. It also addresses the use of nutraceuticals for inflammatory deformities and rickets.
Nuclear Import and Export in Plants and Animals
Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Northeast Asia : Ripe for Integration?
Can regional mechanisms better institutionalize the increasing complexity of economic and security ties among the countries in Northeast Asia? As the international state system undergoes dramatic changes in both security and economic relations in the wake of the end of the Cold War, the Asian financial crisis, and the attack of 9/11, this question is now at the forefront of the minds of both academics and policymakers. Still, little research has been done to integrate the analysis of security and economic analysis of changes in the region within a broader context that will give us theoretically-informed policy insights. Against this backdrop, this book investigates the origins and evolution of Northeast Asia's new institutional architecture in trade, finance, and security from both a theoretical and empirical perspective.
Nonlinear Speech Modeling and Applications : Advanced Lectures and Revised Selected Papers
Presents the revised tutorial lectures given at the International Summer School on Nonlinear Speech Processing-Algorithms and Analysis held in Vietri sul Mare, Salerno, Italy in September 2004. The 14 revised tutorial lectures by leading international researchers are organized in topical sections on dealing with nonlinearities in speech signals, acoustic-to-articulatory modeling of speech phenomena, data driven and speech processing algorithms, and algorithms and models based on speech perception mechanisms. Besides the tutorial lectures, 15 revised reviewed papers are included presenting original research results on task oriented speech applications.
Nonlinear Physical Oceanography : A Dynamical Systems Approach to the Large Scale Ocean Circulation and El Niño
Taken from a review of the first edition in SIAM:"This text is different from most others in that it combines several different disciplines and draws on many scientific studies in order to deduce mechanisms of ocean circulation.
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
Nicotine addiction and its treatment = إدمان النيكوتين وكيفية علاجه
Nicotine is the main cause of smoking addiction, and the custom of preparation for smoking itself and smell of cigarettes create addictive behavior among smokers. Today, nicotine is socially most widely accepted legal drug in the world, and its uptake into the organism through the respiratory tract is 10 times stronger than heroin. Addiction and necessity for cigarettes are constant and intense, and the treatment for smoking addicts is long and difficult. Smoking is a worldwide epidemic, which is closely connected to other addictions such as coffee, alcohol, drugs, and gambling. Smoking cessation is associated with clear health benefits. Cigarette smoking is the leading preventable cause of death in worldwide. In this project we will discuss the nicotine, the mechanism of its addiction and medications used for smoking cessation
New Political Economy of Exchange Rate Policies and the Enlargement of the Eurozone
This work examines the political economy of exchange-rate policies in the context of the eastward enlargement of the eurozone. The analysis shows that prospective members of the EMU are likely to pass on some of the incurred Maastricht costs of convergence to the current EMU-members. The transmission mechanism is an altered exchange-rate policy that is carried out utilizing a "threaten-thy-neighbour"-strategy. The nature of the arising conflict between current and prospective EMU-members originates from both parties' admitted inclination to complete the enlargement process, complicated by their disinclination to bear the costs. The ensuing moral-hazard behaviour of the CEECs proves to be one of brinkmanship.
New Mechanisms for Tissue-Selective Estrogen-Free Contraception
Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.
New Forms of Governance in Research Organizations : Disciplinary Approaches, Interfaces and Integration
This book undertakes to develop a sector specific theory of governance of the public research sector and applies it to the German research system. The book is the outcome of a large interdisciplinary project. It analyzes the reforms in the German research system from an integrated perspective of law, economics and social sciences. First, we pose the question how external competition and control mechanisms do influence internal governance of research institutions and universities and vice versa. Second, we discuss the consequences of these impacts on research.
