الصفحة 1
الصفحة 1
Nutritional psychiatry
Provides a comprehensive overview of nutritional psychiatry, elucidating its theoretical foundations, the biological mechanisms linking diet to mental health (including inflammation, oxidative stress, disrupted energy metabolism the gut–brain axis and other implicated pathways), and the current evidence base for dietary impacts on major psychiatric disorders such as depression, anxiety, schizophrenia, bipolar disorder, and ADHD.
Nonlinear Observers and Applications
The problem of state reconstruction in dynamical systems, known as observer problem, is undoubtedly crucial for controlling or just monitoring processes. For linear systems, the corresponding theory has been quite well established for several years now, and the purpose of the present book is to propose an overview on possible tools in that respect for nonlinear systems. Basic observability notions and observer structures are first recalled, together with ingredients for advanced designs on this basis. A special attention is then paid to the well-known high gain techniques with a summary of various corresponding recent results. A focus on the celebrated Extended Kalman filter is also given, in the perspectives of both nonlinear filtering and high gain observers, leading to so-called adaptive-gain observers. The more specific immersion approach for observer design is then emphasized, while optimization-based methods are also presented as an alternative to analytic observers.
Molecular Mechanisms of Parasite Invasion
All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Mémento de la recherche biomédicale portant sur un médicament à usage humain = Summary of biomedical research on a medicinal product for human use
Presents the reference texts, structures and authorities that govern clinical research in France, as well as its practical aspects. It is aimed at all of its stakeholders, both caregivers and patients. It will allow the most novices to familiarize themselves with the specific vocabulary of this discipline, to answer the questions raised during the conduct or participation in a therapeutic trial, and the most experienced to consider setting up a research structure. clinic in the rules of art.
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007; 10th International Conference, Brisbane, Australia, October 29 - November 2, 2007, Proceedings, Part II
The 10th International Conference on Medical Imaging and Computer Assisted Intervention, MICCAI2007, washeldattheBrisbaneConventionandExhibition Centre, South Bank, Brisbane, Australia from 29th October to 2nd November 2007. MICCAI has become a premier international conference in this domain, with in-depth papers on the multidisciplinary ?elds of biomedical image computing, computer assisted intervention and medical robotics.
Mathematics teacher education in the Andean region and Paraguay : A comparative analysis of issues and challenges
This Open Access book is an excellent synthesis of the initial and continuing preparation for Mathematics Teaching in Bolivia, Ecuador, Paraguay and Peru, from which comparative analyses can be made that show similarities and differences, and highlight various perspectives. This book brings to the international Educational Community an important collection of experiences and ideas in the Mathematics Education of four Latin-American countries in the developing Andean region and Paraguay. The dissemination of these results can promote the search for international collaborative actions in a wider scale.
Introduction to Machine Learning with Applications in Information Security
Provides a classroom-tested introduction to a wide variety of machine learning and deep learning algorithms and techniques, reinforced via realistic applications. The book is accessible and doesn't prove theorems, or dwell on mathematical theory. The goal is to present topics at an intuitive level, with just enough detail to clarify the underlying concepts. The book covers core classic machine learning topics in depth, including Hidden Markov Models (HMM), Support Vector Machines (SVM), and clustering. Additional machine learning topics include k-Nearest Neighbor (k-NN), boosting, Random Forests, and Linear Discriminant Analysis (LDA). The fundamental deep learning topics of backpropagation, Convolutional Neural Networks (CNN), Multilayer Perceptrons (MLP), and Recurrent Neural Networks (RNN) are covered in depth. A broad range of advanced deep learning architectures are also presented, including Long Short-Term Memory (LSTM), Generative Adversarial Networks (GAN), Extreme Learning Machines (ELM), Residual Networks (ResNet), Deep Belief Networks (DBN), Bidirectional Encoder Representations from Transformers (BERT), and Word2Vec.
Imaging Cellular and Molecular Biological Functions
Imaging cellular and molecular biological function’ provides a unique selection of essays by leading experts, aiming at scientist and student alike who are interested in all aspects of modern imaging, from its application and up-scaling to its development. Indeed the philosophy of this volume is to provide student, researcher, PI, professional or provost the means to enter this applications field with confidence, and to construct the means to answer their own specific questions.
High-Pressure Shock Compression of Solids VIII : The Science and Technology of High-Velocity Impact
Research in the field of shock physics and ballistic impact has always been intimately tied to progress in development of facilities for accelerating projectiles to high velocity and instrumentation for recording impact phenomena. The chapters of this book, written by leading US and European experts, cover a broad range of topics and address researchers concerned with questions of material behaviour under impulsive loading and the equations of state of matter, as well as the design of suitable instrumentation such as gas guns and high-speed diagnostics. Applications include high-speed impact dynamics, the inner composition of planets, syntheses of new materials and materials processing. Among the more technologically-oriented applications treated is the testing of the flight characteristics of aeroballistic models and the assessment of impacts in the aerospace industry.
Handbook of Multilevel Analysis
Multilevel analysis is the statistical analysis of hierarchically and non-hierarchically nested data. The simplest example is clustered data, such as a sample of students clustered within schools. Multilevel data are especially prevalent in the social and behavioral sciences and in the bio-medical sciences. The models used for this type of data are linear and nonlinear regression models that account for observed and unobserved heterogeneity at the various levels in the data. This book presents the state of the art in multilevel analysis, with an emphasis on more advanced topics. These topics are discussed conceptually, analyzed mathematically, and illustrated by empirical examples. The authors of the chapters are the leading experts in the field.
Frontiers of Optical Spectroscopy ; Investigating Extreme Physical Conditions with Advanced Optical Techniques
Advanced spectroscopic techniques allow the probing of very small systems and very fast phenomena, conditions that can be considered "extreme" at the present status of our experimentation and knowledge. Quantum dots, nanocrystals and single molecules are examples of the former and events on the femtosecond scale examples of the latter. The purpose of this book is to examine the realm of phenomena of such extreme type and the techniques that permit their investigations. Each author has developed a coherent section of the program starting at a somewhat fundamental level and ultimately reaching the frontier of knowledge in the field in a systematic and didactic fashion. The formal lectures are complemented by additional seminars.
From Animals to Animats 9 ; 9th International Conference on Simulation of Adaptive Behavior, SAB 2006, Rome, Italy, September 25-29, 2006, Proceedings
This book constitutes the refereed proceedings of the 9th International Conference on Simulation of Adaptive Behavior, SAB 2006. The 35 revised full papers and 35 revised poster papers presented are organized in topical sections on the animat approach to adaptive behaviour, perception and motor control, action selection and behavioral sequences, navigation and internal world models, learning and adaptation, evolution, collective and social behaviours, applied adaptive behavior and more.
Experimental Algorithms ; 5th International Workshop, WEA 2006, Cala Galdana, Menorca, Spain, May 24-27, 2006, Proceedings
This book constitutes the refereed proceedings of the 5th International Workshop on Experimental and Efficient Algorithms, WEA 2006, held in Cala Galdana, Menorca, Spain in May 2006. The 26 revised full papers presented together with 3 invited talks were carefully reviewed and selected from 92 submissions. The book is devoted to the design, analysis, implementation, experimental evaluation, and engineering of efficient algorithms. Among the application areas addressed are most fields applying advanced algorithmic techniques.
Distribution and phenotype of proliferating cells in the Forebrain of adult macaque monkeys after transient global cerebral ischemia
The authors' results show that ischemia differentially activates endogenous neural precursors residing in diverse locations of the adult primate central nervous system. A limited endogenous potential for postischemic neuronal repair exists in neocortex and striatum, but not in the hippocampus proper of the adult macaque monkey brain. The presence of putative parenchymal progenitors and of sustained progenitors in germinative centers opens novel possibilities for precursor cell recruitment.
Distributed Services with OpenAFS : For Enterprise and Education
This book shows in detail how to build enterprise-level secure, redundant, and highly scalable services from scratch on top of the open source Linux operating system, suitable for small companies as well as big universities. The core architecture presented is based on Kerberos, LDAP, AFS, and Samba. It is shown how to integrate web, message related, data base and other services with this backbone. This architecture provides a Single-Sign-On solution for different client platforms and can also be employed for clustering. Although it is implemented with Debian GNU/Linux, the content can be applied to other UNIX flavors.
Data Monitoring in Clinical Trials : A Case Studies Approach
Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obtaining the best evidence through clinical trials must be done within the boundaries of rigorous science and ethical principles. One fundamental principle is that trials should not continue longer than necessary to reach their objectives. Therefore, trials must be monitored for recruitment progress, quality of data, adherence to patient care or prevention standards, and early evidence of benefit or harm. Frequently, a group of external experts, independent from the investigators and trial sponsor, is charged with this monitoring responsibility, especially for safety and early benefit. This group is referred to by various names, such as a data monitoring committee or a data and safety monitoring board. This book, through a series of case studies presented by many distinguished clinical trial experts, illustrates the complexity of this monitoring process.No other text has as extensive a collection of cases which provide insight into the many issues, often conflicting, that must be examined before recommendations to continue or discontinue a trial can be made. While depth in statistical methods is not required, some familiarity with statistical design and analysis issues in clinical trials is helpful. The cases cover trials which were terminated early for convincing evidence of benefit, or for harmful effects. Cases with complex issues are also included. This series of cases should provide broad background information for potential monitoring committee members and better prepare them for the challenges that may exist in the trials for which they are responsible.
Computational Welding Mechanics
Provides readers with an introduction to the principles and applications of computational welding. This book instructs the reader how to relate Computational Welding Mechanics (CWM) to the processes of design, build, inspect, regulate, operate and maintain welded structures. It is suited for practicing engineers and engineering students.
Computational Processing of the Portuguese Language ; 8th International Conference, PROPOR 2008 Aveiro, Portugal, September 8-10, 2008 Proceedings
This book constitutes the thoroughly refereed proceedings of the 8th International Workshop on Computational Processing of the Portuguese Language, PROPOR 2008, held in Aveiro, Portugal, in September 2008.
Malaria : Genetic and Evolutionary Aspects
This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004).
Machine learning for data streams : With practical examples in MOA
The book first offers a brief introduction to the topic, covering big data mining, basic methodologies for mining data streams, and a simple example of MOA. More detailed discussions follow, with chapters on sketching techniques, change, classification, ensemble methods, regression, clustering, and frequent pattern mining. Most of these chapters include exercises, an MOA-based lab session, or both. Finally, the book discusses the MOA software, covering the MOA graphical user interface, the command line, use of its API, and the development of new methods within MOA.
