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Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
One Hundred Years of Chemical Warfare : Research, Deployment, Consequences
On April 22, 1915, the German military released 150 tons of chlorine gas at Ypres, Belgium. Carried by a long-awaited wind, the chlorine cloud passed within a few minutes through the British and French trenches, leaving behind at least 1,000 dead and 4,000 injured. This chemical attack, which amounted to the first use of a weapon of mass destruction, marks a turning point in world history. The preparation as well as the execution of the gas attack was orchestrated by Fritz Haber, the director of the Kaiser Wilhelm Institute for Physical Chemistry and Electrochemistry in Berlin-Dahlem. During World War I, Haber transformed his research institute into a center for the development of chemical weapons (and of the means of protection against them).
Numerical Techniques for Chemical and Biological Engineers Using MATLAB® : A Simple Bifurcation Approach
This book addresses the bifurcation characteristics of chemical and biological processes as the general case and treats systems with a unique steady state as special cases. It uses a system approach which is the most efficient for knowledge organization and transfer. The book develops mathematical models for many commercial processes utilizing the mass-, momentum-, and heat-balance equations coupled to the rates of the processes that take place within the boundaries of the system. The models are solved numerically through MATLAB codes with emphasis on the design and optimization of the chemical and biological industrial equipment and plants.
Numerical Simulation of Mechatronic Sensors and Actuators
The second edition of this book fully preserves the character of the first edition to combine the detailed physical modeling of mechatronic systems and their precise numerical simulation using the Finite Element (FE) method. Most of the text and general appearance of the previous edition were retained, while the coverage was extended and the presentation improved. A large part of the book describes the application of the developed numerical calculation schemes to industrial problems, e.g.: analysis and optimization of electrodynamic loudspeakers. In these parts, new computational methods are included, and last but not least, this new edition contains a new chapter on computational aeroacoustics to study the complex phenomenon of flow induced noise.
Numerical Methods Using Java : For Data Science, Analysis, and Engineering
Covers a wide range of topics, including chapters on linear algebra, root finding, curve fitting, differentiation and integration, solving differential equations, random numbers and simulation, a whole suite of unconstrained and constrained optimization algorithms, statistics, regression and time series analysis. The mathematical concepts behind the algorithms are clearly explained, with plenty of code examples and illustrations to help even beginners get started. You will: Program in Java using a high-performance numerical library / Learn the mathematics for a wide range of numerical computing algorithms / Convert ideas and equations into code / Put together algorithms/ and classes to build your own engineering solution / Build solvers for industrial optimization problems / Do data analysis using basic and advanced statistics
Numerical Mathematics and Advanced Applications ENUMATH 2019 ; European Conference, Egmond aan Zee, The Netherlands, September 30 - October 4
It contians basic aspects and new trends in numerical mathematics and scientific and industrial applications, all examined at the highest level of international expertise.
Nuclear back-end and transmutation technology for waste disposal : Beyond the Fukushima accident
Covers essential aspects of transmutation technologies, highlighting especially the advances in Japan. The accident at the Fukushima Daiichi Nuclear Power Plant (NPP) has caused us to focus attention on a large amount of spent nuclear fuels stored in NPPs. In addition, public anxiety regarding the treatment and disposal of high-level radioactive wastes that require long-term control is growing. The Japanese policy on the back-end of the nuclear fuel cycle is still unpredictable in the aftermath of the accident. Therefore, research and development for enhancing the safety of various processes involved in nuclear energy production are being actively pursued worldwide.
Novel food grade enzymes : Applications in food processing and preservation industries
Covers all the aspects of food-grade enzymes, including their classification, kinetics, microbial production, biosynthetic pathways, commodity-wise industrial applications, and downstream processing strategies. The broad focus of this book is on the application of various classes of enzymes in dairy, fruits and vegetables, cereals and oilseeds, meat and poultry, and brewing and food packaging industries. Certain recent areas such as nanotechnological perspective in enzyme immobilization, infusion strategies as well as its efficient usage in food packaging and preservation are some of the salient highlights of this book. This book also discusses the aspects related to application of enzymes in functional food development and shelf life extension of various commodities food products.
Novel algorithms and techniques In telecommunications, automation and industrial electronics
Novel Algorithms and Techniques in Telecommunications, Automation and Industrial Electronics includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of Industrial Electronics, Technology & Automation, Telecommunications and Networking.
Nonparametric Bayesian Learning for Collaborative Robot Multimodal Introspection
This book focuses on robot introspection, which has a direct impact on physical human–robot interaction and long-term autonomy, and which can benefit from autonomous anomaly monitoring and diagnosis, as well as anomaly recovery strategies.
Nonlinear kalman filtering for force-controlled robot tasks
This monograph focuses on how to achieve more robot autonomy by means of reliable processing skills. "Nonlinear Kalman Filtering for Force-Controlled Robot Tasks " discusses the latest developments in the areas of contact modeling, nonlinear parameter estimation and task plan optimization for improved estimation accuracy.
Non-Linear Electromechanics
This is the first book in which problems of electromechanics are considered from the perspective of analytical mechanics. The book includes fundamental results in the theory of non-linear electromechanical systems and will be useful both for researchers, engineers, scholars and graduate students of electromechanical faculties of technical universities. It includes not only theoretical results but also various examples from many industrial applications. A sizeable part of the book is devoted to the general theory of synchronous machines and electro-magnetic exciters of oscillations.
Nonlinear Analysis and Synthesis Techniques for Aircraft Control
Given the continuous increase in the complexity of aircraft control laws, and the corresponding - crease in the demands on their performance and reliability, industrial control law designers are highly motivated to explore the applicability of new and more powerful methods for design and analysis. The successful application of fully nonlinear control techniques to aircraft control problems o?ers the prospect of improvements in several di?erent areas. Firstly, there is the possibility of - proving design and analysis criteria to more fully re?ect the nonlinear nature of the dynamics of the aircraft. Secondly, the time and e?ort required on the part of designers to meet demanding speci?cations on aircraft performance and h- dling could be reduced. Thirdly, nonlinear analysis techniques could potentially reduce the time and resources required to clear ?ight control laws, and help to bridge the gap between design, analysis and ?nal ?ight clearance.
Next Generation Supply Chains : A Roadmap for Research and Innovation
This book explores supply chains strategies to help companies face challenges such as societal emergency, digitalization, climate changes and scarcity of resources. The book identifies industrial scenarios for the next decade based on the analysis of trends at social, economic, environmental technological and political level, and examines how they may impact on supply chain processes and how to design next generation supply chains to answer these challenges.
Next Generation Design and Verification Methodologies for Distributed Embedded Control Systems ; Proceedings of the GM R&D Workshop, Bangalore, India, January 2007
This volume is the proceedings of the workshop “Next Generation Design and Verification Methodologies for Distributed Embedded Control Systems” organised by General Motors R&D, India Science Lab. The workshop was held on January 5-6 2007 at the NIAS auditorium, IISc campus, Bangalore, India. This workshop is the first of its kind to be organised by an automotive major to bring together the leaders in the field of embedded systems development to present state-of-the-art work, and to discuss future strategies for addressing the increasing complexity of embedded control systems. The workshop consisted of invited talks given by leading experts and researchers from academic and industrial organizations.
New Trends in Applied Artificial Intelligence ; 20th International Conference on Industrial, Engineering, and Other Applications of Applied Intelligent Systems. IEA/AIE 2007, Kyoto, Japan, June 26-29, 2007, Proceedings
The 20 International Conference on Industrial, Engineering and Other Applications of Applied Intelligent S- tems (IEA/AIE-2007) held in Kyoto, Japan presented such work performed by many scientists worldwide. The previous IEA/AIE conference held in Japan was the Ninth International Conference on Industrial and Engineering Applications of Arti?cial Intelligence and Expert systems (IEA/AIE-1996) in Fukuoka in 1996.
New Methodologies and Techniques for a Sustainable Organic Chemistry
Chemical industries have to face the big challenge of finding adequate processes to produce large quantities of new products for which there is a present need, decreasing at the same time both the impact on the environment and the risk of disasters. These issues have led to the establishment of new concepts of sustainable development as affirmed in the Rio Declaration on Environment and Development in the early 90’s and has been the subject of intensive studies in the last two decades. The book addresses this challenge collecting the recent “New Methodologies and Techniques for a Sustainable Organic Chemistry”.
New Frontiers in Applied Artificial Intelligence ; 21st International Conference on Industrial, Engineering and Other Applications of Applied Intelligent Systems, IEA/AIE 2008 Wrocław, Poland, June 18-20, 2008 Proceedings
The 75 revised full papers presented were carefully reviewed and selected from 302 submissions. The papers are organized in topical sections on computer vision, fuzzy system applications, robot and manufacturing, data mining and KDS, neural networks, machine learning, natural language processing, internet application and education, heuristic search, application systems, agent-based system, evolutionary and genetic algorithms, knowledge management, and other applications. The book concludes with 15 contributions from the following special sessions: knowledge driven manufacturing systems, joint session on adaptive networked systems and fuzzy knowledge bases, and software agents and multi-agent systems.
New Directions : Efficiency and Productivity
The key unifying conceptual tool of this important entry in the study of efficiency and productivity is the directional distance function. In New Directions the authors take up this new performance measure while also maintaining their ''traditional'' axiomatic production theoretic approach.
New Design for Old Buildings
Explores design, materials and technical considerations in creating the best low energy, ecological and sustainable retrofits. It has never been more important to understand how old buildings can be adapted to make them useful and sustainable in the future. Showcasing the best examples of imaginative design and best practice, this book illustrates how old buildings can be made sustainable through the best new design and puts these design exemplars into a historical and philosophical context. With illustrative case studies and interviews throughout, including formal buildings, churches, domestic buildings, commercial, industrial and agricultural from all periods in the UK, New Design for Old Buildings provides essential guidance on good, imaginative new design for old buildings.
