الصفحة 1
الصفحة 1
Omega-3 fatty acids : Keys to nutritional health
Argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health.
Ocean-atmosphere interactions of gases and particles
The oceans and atmosphere interact through various processes, including the transfer of momentum, heat, gases and particles. In this book leading international experts come together to provide a state-of-the-art account of these exchanges and their role in the Earth-system, with particular focus on gases and particles. Chapters in the book cover: i) the ocean-atmosphere exchange of short-lived trace gases; ii) mechanisms and models of interfacial exchange (including transfer velocity parameterisations); iii) ocean-atmosphere exchange of the greenhouse gases carbon dioxide, methane and nitrous oxide; iv) ocean atmosphere exchange of particles and v) current and future data collection and synthesis efforts.
Obesity and Cancer
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development.
Nutritional psychiatry
Provides a comprehensive overview of nutritional psychiatry, elucidating its theoretical foundations, the biological mechanisms linking diet to mental health (including inflammation, oxidative stress, disrupted energy metabolism the gut–brain axis and other implicated pathways), and the current evidence base for dietary impacts on major psychiatric disorders such as depression, anxiety, schizophrenia, bipolar disorder, and ADHD.
Nuclear pre-mRNA Processing in Plants
In recent years nuclear pre-mRNA processing has taken center stage as an important regulator of gene expression and ultimately growth and development. Large-scale genome and cDNA sequencing projects together with bioinformatic analyses of these sequences have revealed that alternative splicing of pre-mRNAs contributes greatly to transcriptome and proteome complexity in eukaryotes. During the last few years, tremendous progress has been made in understanding various aspects of pre-mRNA processing including alternative splicing and its importance in plant growth and development as well as in plant responses to hormones and stresses. This book, with contributions from leading scientists in this area, summarizes recent advances in nuclear pre-mRNA processing in plants. It provides researchers in the field, as well as those in related areas, with an up-to-date and comprehensive, yet concise, overview of the current status and future potential of this research in understanding plant biology.
Novel food grade enzymes : Applications in food processing and preservation industries
Covers all the aspects of food-grade enzymes, including their classification, kinetics, microbial production, biosynthetic pathways, commodity-wise industrial applications, and downstream processing strategies. The broad focus of this book is on the application of various classes of enzymes in dairy, fruits and vegetables, cereals and oilseeds, meat and poultry, and brewing and food packaging industries. Certain recent areas such as nanotechnological perspective in enzyme immobilization, infusion strategies as well as its efficient usage in food packaging and preservation are some of the salient highlights of this book. This book also discusses the aspects related to application of enzymes in functional food development and shelf life extension of various commodities food products.
Notch Signaling in Embryology and Cancer : Notch Signaling in Cancer
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more.
Nonlinear Smoothing and Multiresolution Analysis
This monograph presents a new theory for analysis, comparison and design of nonlinear smoothers, linking to established practices. Although a part of mathematical morphology, the special properties yield many simple, powerful and illuminating results leading to a novel nonlinear multiresolution analysis with pulses that may be as natural to vision as wavelet analysis is to acoustics. Similar to median transforms, they have the advantages of a supporting theory, computational simplicity, remarkable consistency, full trend preservation, and a Parceval-type identity.
Noncommutative Geometry and Number Theory : Where Arithmetic meets Geometry and Physics
This volume collects and presents up-to-date research topics in arithmetic and noncommutative geometry and ideas from physics that point to possible new connections between the fields of number theory, algebraic geometry and noncommutative geometry. The articles collected in this volume present new noncommutative geometry perspectives on classical topics of number theory and arithmetic such as modular forms, class field theory, the theory of reductive p-adic groups, Shimura varieties, the local Lfactors of arithmetic varieties. They also show how arithmetic appears naturally in noncommutative geometry and in physics, in the residues of Feynman graphs, in the properties of noncommutative tori, and in the quantum Hall effect.
Nitric oxide in plants : A molecule with dual roles
Studies have identified the central role of nitric oxide in stress mitigation through the modulation of physiological and biochemical pathways including germination, photosynthesis regulation, and programmed cell death. Nitric Oxide in Plants: A Molecule with Dual Roles provides a detailed account of the physio-biochemical, molecular, and omic basis of NO-mediated responses in crop plants under different stresses.
New and Old Routes of Portuguese Emigration : Uncertain Futures at the Periphery of Europe
This book offers a comparative overview on Portuguese emigration in Europe and outside the EU in times of recession. In addition to the dynamics of movement, the book provides an in-depth analysis of the heterogeneity of this emigration. It deepens the multifaceted identities concerning social and professional pathways among highly skilled and less skilled emigrants. The labour market continues to be the main regulatory force of Portuguese emigration, which helps to explain the outflow and the processes of settlement and return. Nonetheless, this book demonstrates that non-economic factors have likewise been of great importance in the decision to emigrate.
Neuronal Input Pathways to the Brains Biological Clock and their Functional Significance
Circadian rhythms are entrained daily by environmental photic and non-photic cues. The present review describes the anatomy and functional characteristics of the three major input pathways to the circadian clock mediating entrainment, the retino-hypothalamic tract (RHT), the geniculo-hypothalamic tract (GHT) and the midbrain raphe projection.
Neuroblastoma
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Network Analysis : Methodological Foundations
‘Network’ is a heavily overloaded term, so that ‘network analysis’ means different things to different people. Specific forms of network analysis are used in the study of diverse structures such as the Internet, interlocking directorates, transportation systems, epidemic spreading, metabolic pathways, the Web graph, electrical circuits, project plans, and so on. There is, however, a broad methodological foundation which is quickly becoming a prerequisite for researchers and practitioners working with network models. From a computer science perspective, network analysis is applied graph theory. Unlike standard graph theory books, the content of this book is organized according to methods for specific levels of analysis (element, group, network) rather than abstract concepts like paths, matchings, or spanning subgraphs. Its topics therefore range from vertex centrality to graph clustering and the evolution of scale-free networks. In 15 coherent chapters, this monograph-like tutorial book introduces and surveys the concepts and methods that drive network analysis, and is thus the first book to do so from a methodological perspective independent of specific application areas.
Napoleonic Governance in the Netherlands and Northwest Germany : Conquest, Incorporation, and Integration
This Palgrave Pivot explores the ways in which French Emperor Napoleon tried to integrate the present-day Netherlands and Northwest Germany into his Empire, by replacing traditional institutions and governing practices with French ones ('Napoleonic governance'). The northern periphery of the Napoleonic Empire continues to be overlooked by the bulk of historians; this study shows that a transregional approach can yield important findings. In a broader sense, the study does not deal with these regions alone, but also with the difficulties that are inherent to European integration.
Nanopharmaceuticals : Vol.3 : Principles and applications
Focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Multi-objective Management in Freight Logistics : Increasing Capacity, Service Level and Safety with Optimization Algorithms
Multi-objective Management in Freight Logistics provides decision makers with new methods and tools to implement multi-objective optimization models in logistics. The book combines theoretical aspects with applications, showing the advantages and the drawbacks of adopting scalarization techniques, and when it is worthwhile to reduce the problem to a goal programming one. The book also shows applications where more than one decision maker evaluates the effectiveness of the logistic system and thus a multilevel programming approach is sought to attain meaningful solutions.
Multi-dimensional Approaches Towards New Technology : Insights on Innovation, Patents and Competition
This open access edited book captures the complexities and conflicts arising at the interface of intellectual property rights (IPR) and competition law. To do so, it discusses four specific themes: (a) policies governing functioning of standard setting organizations (SSOs), transparency and incentivising future innovation; (b) issue of royalties for standard essential patents (SEPs) and related disputes; (c) due process principles, procedural fairness and best practices in competition law; and (d) coherence of patent policies and consonance with competition law to support innovation in new technologies.
Mortality and Maldevelopment : Part I : Congenital cardiovascular malformations
The most frequent of them all are the many types of malformations of the cardiovascular system, the heart and its blood vessels.Study of these conditions during the twentieth century took many forms, revolving about examination and analysis of their causes, genetic, nongenetic, and complex. To aid in unraveling the complexities of this causation, various influences on their frequency are considered, among them social conditions, maternal health, birthweight, newborn maturity. And of course the known and possible environmental bases of their occurrence are fully described.
Molecular mechanisms in nutritional epigenetics
The field of nutritional epigenetics/nutri-epigenetics has expanded significantly, shedding light on how environmentally-driven epigenetic pathways can be modulated through nutrition and eating habits. The book provides a comprehensive introduction to the various epigenetic mechanisms affected by dietary compounds and focuses on specific topics such as the relationship between diet and the gut microbiome, the impact of diet on cardiovascular disease and psychopathology and the role of diet in pregnancy.
