الصفحة 1
الصفحة 1
Fundamentals of Renal Pathology
This book will provide the general pathologist, pathology residents and fellows in training, the renal pathologist, and the nephrologist and nephrology resident, with a compact and up-to-date resource on the basics of renal pathology. Beginning with the basic concepts and methods in renal pathology, the text covers renal anatomy, including gross and miscroscopic appearance and pathogenic mechanisms in renal diseases.
Kidney complications & transplantation
Kidney diseases are worldwide public health problems with a high cost and increasing incidence. By revealing the genetic and cellular mechanism behind mammalian kidney development, better diagnostic methods and novel therapies can be expected to be developed. The mammalian kidney is a typical organ that develops on the basis of sequential and reciprocal cell and tissue interactions. Pyelonephritis, Glomerulonephritis, Kidney stones, Nephrotic syndrome, and Acute or chronic kidney failure are the most complications in the kidney kingdom, so that living kidney transplantation has become the preferred treatment for those patients who can’t have the powerful capacity of the kidney function, and here it has a very rejection risk in the first month and we can controlled in this situation with long term immunosuppressant therapy involved in the post-transplantation protocol.
Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
