الصفحة 1
الصفحة 1
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Nonlinear Partial Differential Equations with Applications
This book primarily concerns quasilinear and semilinear elliptic and parabolic partial differential equations, inequalities, and systems. It balances the abstract functional-analysis approach based on nonlinear monotone, pseudomonotone, weakly continuous, or accretive mappings with concrete partial differential equations in their weak (or more general) formulation. Methods of Galerkin or of Rothe are exposed in a large generality. Other methods include various direct methods, regularization, or fixed points. The exposition leads general theory as fast as possible towards the analysis of concrete equations, which have specific applications in continuum (thermo-) mechanics of solids and fluids, electrically (semi-) conductive media, modelling of biological systems, or in mechanical engineering. Selected parts are rather an introduction into the subject while some others form an advanced textbook. The intended audience is graduate and PhD students and researchers in the theory of partial differential equations or in mathematical modelling of distributed parameter systems.
Munson, Young and Okiishi's fundamentals of fluid mechanics ; 9th ed.
ffers comprehensive topical coverage, with varied examples and problems, application of the visual component of fluid mechanics, and a strong focus on effective learning. The authors have designed their presentation to enable the gradual development of reader confidence in problem solving. Each important concept is introduced in easy-to-understand terms before more complicated examples are discussed. The 9th Edition includes new coverage of finite control volume analysis and compressible flow, as well as a selection of new problems. Continuing this important work’s tradition of extensive real-world applications, each chapter includes The Wide World of Fluids case study boxes in each chapter. In addition, there are a wide variety of videos designed to enhance comprehension, support visualization skill building and engage students more deeply with the material and concepts.
Models of Mechanics
This is a textbook on models and modeling in mechanics. It introduces a new unifying approach to applied mechanics: through the concept of the open scheme, a step-by-step approach to modeling evolves. The unifying approach enables a very large scope on relatively few pages: the book treats theories of mass points and rigid bodies, continuum models of solids and fluids, as well as traditional engineering mechanics of beams, cables, pipe flow and wave propagation.
Models for Polymeric and Anisotropic Liquids
Models should be as simple as possible, but no simpler. For the physics of polymeric liquids, whose relevant lengths and time scales are out of reach for first principles calculations, this means that we have to choose a minimum set of sufficiently detailed descriptors such as architecture (linear, ring, branched), connectivity, semiflexibility, stretchability, excluded volume, and hydrodynamic interaction. These 'universal' fluids allow the prediction of material properties under external flow- or electrodynamic fields, the results being expressed in terms of reference units, specific for any particular chosen material. This book provides an introduction to the kinetic theory and computer simulation methods needed to handle these models and to interpret the results. Also included are a number of sample applications and computer codes.
Introduction to Pharmaceutical Analytical Chemistry
Enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.
Human microbiome : Clinical implications and therapeutic interventions
The human microbiome refers to the complete microorganisms inhabiting the human body sites including skin, ear, nose, oral cavity, the genital, gastrointestinal and respiratory tracts, and body fluids such as breast milk, saliva, and urine. It is a significant and essential organ recognized for the body and has an established involvement in the host wellbeing, in terms of nutritional requirements and immunomodulation. Talks about how alteration and imbalance in the same can have clinical implications associated with a multitude of gastrointestinal, lifestyle-associated, and neurodegenerative disorders. How the proliferation of specific groups of bacteria and their metabolic activities, as a result of intestinal dysbiosis leads to the 'leaky gut' condition thereby influences brain activity via the bidirectional gut-brain axis. It also coves the importance of microbial seeding and how it can be influenced by the mode of delivery, nutrition, and medication. This book also provides various therapeutic interventions such as the establishment of stool banks and Faecal microbiota transplantation (FMT) that have recently proved promising in the treatment of ASD, Inflammatory Bowel Disease, and Ulcerative Colitis. This book provides a deeper understanding of the development of the human gut microbiome and the factors driving its dysbiosis. This book is a valuable read for health professionals, medical students, nutritionists, and scientific research communities who are eager to update themselves with recent trends in microbiome research. It will also aid gastroenterologists and nutritionists to make well-informed choices regarding therapeutic regimes.
Heat transfer : Evolution, design and performance
Covers thermodynamics principles and establishes performance and evolution as fundamental concepts in thermal sciences Demonstrates how principles of physics predict a future with economies of scale, multi-scale design, vascularization, and hierarchical distribution of many small features Explores new work on conduction architecture, convection with nanofluids, boiling and condensation on designed surfaces, and resonance of natural circulation in enclosures
Handbook of Materials Modeling
The first reference of its kind in the rapidly emerging field of computational approachs to materials research, this is a compendium of perspective-providing and topical articles written to inform students and non-specialists of the current status and capabilities of modelling and simulation. From the standpoint of methodology, the development follows a multiscale approach with emphasis on electronic-structure, atomistic, and mesoscale methods, as well as mathematical analysis and rate processes. Basic models are treated across traditional disciplines, not only in the discussion of methods but also in chapters on crystal defects, microstructure, fluids, polymers and soft matter. Written by authors who are actively participating in the current development, this collection of 150 articles has the breadth and depth to be a major contributor toward defining the field of computational materials. In addition, there are 40 commentaries by highly respected researchers, presenting various views that should interest the future generations of the community.
Free Surface Flows under Compensated Gravity Conditions
Considers the behavior of fluids in a low-gravity environment with special emphasis on application in PMD (propellant management device) systems . This book treats three different flow problems with analytical, numerical and experimental means: the transient contour change between two static surface configurations (free surface oscillations), the capillary rise in tubes (capillary rise), and the flow through open capillary channels (choking).
Free Convection Film Flows and Heat Transfer
This book presents recent developments in systematic studies of hydrodynamics and heat and mass transfer in laminar free convection, accelerating film boiling and condensation of Newtonian fluids, as well as accelerating film flow of non-Newtonian power-law fluids (FFNF). A novel system of analysis models is provided with a developed velocity component method, instead of traditional Falkner-Skan type transformation, and a system of models for treatment of variable thermophysical properties is presented with an innovative temperature parameter method that makes it easier to similarly treat related governing differential equations for consideration of fluid variable thermophysical properties. A pseudo-similarity method is applied for dealing with thermal boundary layer of FFNF, furthermore, with an induced local Prandtl number, which greatly simplifies the heat-transfer analysis and numerical calculation.
Fluid Mechanics : An Introduction to the Theory of Fluid Flows
Advancements of fluid flow measuring techniques and of computational methods have led to new ways to treat laminar and turbulent flows. These methods are extensively used these days in research and engineering practise. This also requires new ways to teach the subject to students at higher educational institutions in an introductory manner. The book provides the knowledge to students in engineering and natural science needed to enter fluid mechanics applications in various fields. Analytical treatments are provided, based on the Navier-Stokes equations. Introductions are also given into numerical and experimental methods applied to flows. The main benefit the reader will derive from the book is a sound introduction into all aspects of fluid mechanics covering all relevant subfields.
Fluid and thermodynamics ; Vol.1 : Basic fluid mechanics
Simple, yet precise solutions to special flows are also constructed, namely Blasius boundary layer flows, matched asymptotics of the Navier-Stokes equations, global laws of steady and unsteady boundary layer flows and laminar and turbulent pipe flows
Flowing Matter
This book presents an introduction to selected research topics in the broad field of flowing matter, including the dynamics of fluids with a complex internal structure -from nematic fluids to soft glasses- as well as active matter and turbulent phenomena. Flowing matter is a subject at the crossroads between physics, mathematics, chemistry, engineering, biology and earth sciences, and relies on a multidisciplinary approach to describe the emergence of the macroscopic behaviours in a system from the coordinated dynamics of its microscopic constituents. Depending on the microscopic interactions, an assembly of molecules or of mesoscopic particles can flow like a simple Newtonian fluid, deform elastically like a solid or behave in a complex manner. When the internal constituents are active, as for biological entities, one generally observes complex large-scale collective motions. Phenomenology is further complicated by the invariable tendency of fluids to display chaos at the large scales or when stirred strongly enough. This volume presents several research topics that address these phenomena encompassing the traditional micro-, meso-, and macro-scales descriptions, and contributes to our understanding of the fundamentals of flowing matter.
Finite Element Methods in Civil and Mechanical Engineering : A Mathematical Introduction
The finite element method is widely employed for numerical simulations in engineering and science due to its accuracy and efficiency. This concise introduction to the mathematical theory of the finite element method presents a selection of applications in civil and mechanical engineering including beams, elastic membranes, the wave equation, heat transfer, seepage in embankment, soil consolidation, incompressible fluids, and linear elasticity.
Equilibrium statistical physics : Phases of matter and phase transitions
This is a textbook which gradually introduces the student to the statistical mechanical study of the different phases of matter and to the phase transitions between them. Throughout, only simple models of both ordinary and soft matter are used but these are studied in full detail. The subject is developed in a pedagogical manner, starting from the basics, going from the simple ideal systems to the interacting systems, and ending with the more modern topics. The latter include the renormalisation group approach to critical phenomena, the density functional theory of interfaces, the topological defects of nematic liquid crystals and the kinematic aspects of the phase transformation process. This textbook provides the student with a complete overview, intentionally at an introductory level, of the theory of phase transitions. References include suggestions for more detailed treatments and four appendices supply overviews of the mathematical tools employed in the text.
Engineering thermofluids : Thermodynamics, fluid mechanics, and heat transfer
The "Engineering Thermofluids" is a unique textbook, which brings the three pillars of thermal sciences; thermodynamics, fluid mechanics, and heat transfer under one umbrella. These three distinct, yet intertwined subjects are treated in an integrated manner. The primary audiences for this book are senior undergraduate, graduate, and practicing engineers in the fields of aeronautical, chemical industrial, mechanical, and nuclear engineering. Topics are discussed in detail while still using a simple and easy to follow approach. Numerous walk-through examples are solved and illustrations are provided to guide the reader through more subtle topics
Engineering Fluid Mechanics
The intended purpose of this book is to provide the fundamental and physical aspects of fluid mechanics and to develop engineering practice for fluid machineries. The subject of fluid engineering is most often approached at the senior undergraduate or postgraduate level of study.
Encyclopedia of Microfluidics and Nanofluidics
Covering all aspects of transport phenomena on the nano- and micro-scale, Springer’s Encyclopedia of Microfluidics and Nanofluidics includes over 750 entries in three alphabetically-arranged volumes including the most up-to-date research, insights, and applied techniques across all areas. Specifically, subjects covered in this comprehensive Springer Reference include electrical double-layers, optofluidics, DNC lab-on-a-chip, nanosensors, and more.
