الصفحة 1
الصفحة 1
Engineering of Functional Skeletal Tissues
This volume discusses current knowledge of bone replacement. It is designed to integrate biological and engineering knowledge. The biology of stem cells and cell signals, knowledge needed to make stem cell engineered bone tissue a reality and how to prevent bone allograft infection is discussed. In addition, non-degradable and biodegradable scaffolds, necessary implants to attract bone cells and to build suitable bone replacements follows. Other topics include motion and bone degeneration analysis and how mechanical factors affect bone healing, implants and how they have become a major tool in reparative dentistry and the application of computational modeling to prosthesis design.
Bone Resorption
Bone Resorption, the second volume in the series Topics in Bone Biology, deals with the osteoclast, the bone-resorbing cell, its origins, its enzymes, the regulation of osteoclast activity, and structural aspects of bone resorption. Diseases involving osteoclast function are discussed from the genetic viewpoint in two chapters that span transgenic mouse models to human pathology. Another chapter treats diseases of osteoclast function. Because osteoporosis may be considered a disease in which the bone resorption rate exceeds formation, a separate chapter deals with current and potential therapeutic approaches to this widespread disease that affects both men and women. Bone metastases and an analysis of the central role of the osteoclast in this condition are treated in the concluding chapter.
Bone and Osteoarthritis
Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease.
