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الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
One-Dimensional Nanostructures
One-dimensional (1D) nanostructures, including nanowires, nanotubes and quantum wires, have been regarded as the most promising building blocks for nanoscale electronic and optoelectronic devices. Worldwide efforts in both the theory and the experimental investigation of growth, characterization and applications of 1D nanostructures have resulted in a mature, multidisciplinary field. In this book, a wealth of state-of-the-art information offers the opportunity to uncover the underlying science from diverse perspectives. Leading researchers elucidate the synthesis and properties of 1D nanostructures for various morphologies and compositions (semiconductor, metal, carbon, etc.) as well as their considerable impact on spintronics, information storage, and the design of field-effect transistors.
Ocean Waves Breaking and Marine Aerosol Fluxes
This book presents a comprehensive study on the breaking of surface waves induced by wind and the relationship of breaking rate with marine aerosol fluxes. The book draws attention to the theoretical and experimental achievements in the study of wave breaking phenomena in deep water seas. In particular, it deals with the important problems of energy dissipation and the estimation of energy loss due to wave breaking in deep waters. The rationale behind existing methods and practical outcomes for the estimation of whitecap coverage of the sea surface and energy dissipation rate are given in detail.The book also focuses on the fundamentals of marine aerosols and their generation. The text provides a comprehensive overview of the currently available experimental data on marine aerosol fluxes and presents theoretical methodology of the estimation of the intensity of sea aerosol production. The systematic analysis leads to a novel approach in the development of links between aerosol production with sea state parameters and its seasonal variation in deep water seas.
Numerical and Practical Exercises in Thermoluminescence
Thermoluminescence (TL) is a well-established technique widely used in dosimetric and dating applications. Although several excellent reference books exist which document both the theoretical and experimental aspects of TL, there is a general lack of books that deal with specific numerical and practical aspects of analyzing TL data. Many times the practical details of analyzing numerical TL glow curves and of applying theoretical models are difficult to find in the published literature. Numerical and Practical Exercises in Thermoluminescence provides a practical guide for both established researchers and for new graduate students entering the field of TL, and is intended to be used in conjunction with and as a practical supplement to standard textbooks in the field.
Nucleic Acids Hybridization : Modern Applications
Several approaches, such as microarray hybridization, have become extremely popular tools for specialists in biochemistry and biomedicine, while the potential of many other advantageous techniques seems to be underestimated. Written by an international team of authors, this book details the current state-of-art in hybridization techniques. Coverage includes experimental protocols along with comprehensive and detailed method descriptions.
Nuclear Condensed Matter Physics with Synchrotron : Basic Principles, Methodology and Applications
This book provides a comprehensive introduction to the growing field of nuclear condensed matter physics with synchrotron radiation, a technique which finds numerous applications in fields such as magnetism, physics of surfaces and interfaces, lattice dynamics and more. Due to the enormous brilliance of modern synchrotron radiation sources, the method is particularly suited for the investigation of low-dimensional structures such as thin films and nanoparticles. The use of isotopic probe layers, for example, allows one to determine magnetic and vibrational properties with very high spatial resolution; focusing techniques and x-ray interference effects lead to a very high sensitivity for smallest amounts of material. The book is written on an introductory level with many examples employed to illustrate the special experimental possibilities.
Nonsmooth Mechanics and Analysis : Theoretical and Numerical Advances
Nonsmooth mechanics concerns mechanical situations with possible nondifferentiable relationships, eventually discontinuous, as unilateral contact, dry friction, collisions, plasticity, damage, and phase transition. The basis of the approach consists in dealing with such problems without resorting to any regularization process. Indeed, the nonsmoothness is due to simplified mechanical modeling; a more sophisticated model would require too large a number of variables, and sometimes the mechanical information is not available via experimental investigations. Therefore, the mathematical formulation becomes nonsmooth; regularizing would only be a trick of arithmetic without any physical justification. Nonsmooth analysis was developed, especially in Montpellier, to provide specific theoretical and numerical tools to deal with nonsmoothness. It is important not only in mechanics but also in physics, robotics, and economics.
Nonlinear Waves : Classical and Quantum Aspects
Leading scientists discuss the most recent physical and experimental results in the physics of Bose-Einstein condensate theory, the theory of nonlinear lattices (including quantum and nonlinear lattices), and nonlinear optics and photonics. Classical and quantum aspects of the dynamics of nonlinear waves are considered. The contributions focus on the Gross-Pitaevskii equation and on the quantum nonlinear Schrödinger equation. Recent experimental results on atomic condensates and hydrogen bonded systems are reviewed. Particular attention is given to nonlinear matter waves in periodic potential.
Non-Linear Optical Properties of Matte : From molecules to condensed phases
Non-Linear Optical Properties of Matter: From Molecules to Condensed Phases attempts to draw together both theory and application in this field. As such it will be of interest to both experimentalists and theoreticians alike. Divided into two parts, Part 1 is concerned with the theory and computing of non-linear optical (NLO) properties while Part 2 reviews the latest developments in experimentation.This book will be invaluable to researchers and students in academia and industry. It will be of particular interest to anyone involved in materials science, theoretical and computational chemistry, chemical physics, and molecular physics.
Nonlinear Dielectric Phenomena in Complex Liquids
Complex liquids constitute a basic element in modern materials science; their significant features include self-assembly, mesoscale structures, complex dynamics, unusual phases and enormous sensitivity to perturbations. Understanding their nature and properties are a great challenge to modern materials science that demands novel approaches. This book focuses on nonlinear dielectric phenomena, particularly on nonlinear dielectric spectroscopy (NDS), which may be considered a possible successor to broadband dielectric spectroscopy (BDS). NDS phenomena directly coupled to mesoscale heterogeneity fluctuations, so information obtained in this way is basically complementary to BDS tests. The book also discusses the application of NDS in a set of complex liquid systems: glassy liquids, liquid crystals, liquids with critical point phenomena, and bio-relevant liquids. The complementary application of NDS and BDS may allow the discovery of universal patterns for the whole category of complex liquids. Written by specialists in the field of nonlinear dielectric studies, theoreticians and experimentalists, ranging from solid state physics to biophysics, the book is organized so that it can serve as a basic textbook for a non-experienced reader.
Non-Equilibrium Phase Transitions ; Vol. I : Absorbing Phase Transitions
This book describes two main classes of non-equilibrium phase-transitions: (a) static and dynamics of transitions into an absorbing state, and (b) dynamical scaling in far-from-equilibrium relaxation behaviour and ageing. The first volume begins with an introductory chapter which recalls the main concepts of phase-transitions, set for the convenience of the reader in an equilibrium context. The extension to non-equilibrium systems is made by using directed percolation as the main paradigm of absorbing phase transitions and in view of the richness of the known results an entire chapter is devoted to it, including a discussion of recent experimental results. Scaling theories and a large set of both numerical and analytical methods for the study of non-equilibrium phase transitions are thoroughly discussed.
Noise-Induced Transitions : Theory and Applications in Physics, Chemistry, and Biology
This classic text, an often-requested reprint, develops and explains the foundations of noise-induced processes. At its core is a self-contained, textbook-style presentation of the elements of probability theory, of the theory of Markovian diffusion processes and of the theory of stochastic differential equations, on which the modeling of fluctuating natural and artificial environments is based. Following an introduction to the mathematical tools, the occurrence and the properties of noise-induced transitions are then analyzed for rapidly fluctuating environments describable by the white-noise idealization. Subsequently, more realistic and general types of colored noises are considered. Appropriate practical methods for dealing with these situations are developed. The latter part of the book contains applications and experimental studies illustrating the many facets of noise-induced transitions. The following applications are considered in Noise-Induced Transitions: population dynamics, electrical circuits, chemical and photochemical reactions, non-linear optics, and hydrodynamical systems.
NMR - From Spectra to Structures : An Experimental Approach
Nuclear magnetic resonance spectroscopy is one of the most powerful analytical methods. This practice-oriented textbook aims at teaching how NMR experiments should be used to make structural asssignments. The book is intended as a practical guide for students and laboratory personnel, so that the emphasis is on practical rather than on theoretical aspects, which are treated only to the extent necessary to understand the experiments and to interpret the results.The second edition has been expanded to include several other heteronuclei (15N, 19F, 29Si, 77Se, 113Cd, 117Sn/119Sn, 195Pt, 207Pb) and a new chapter on solid state NMR. The problems section has been enlarged and now includes 50 problems.
NF-kB/Rel Transcription Factor Family
Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.
New Results in Numerical and Experimental Fluid Mechanics VI ; Contributions to the 15th STAB/DGLR Symposium Darmstadt, Germany, 2006
The volume gives a broad overview over the ongoing work in this field in Germany, with the topics being high-aspect ratio wings, low aspect-ratio wings, bluff bodies, laminar flow control and transition, active flow control, hypersonic flows, aeroelasticity, aeroacoustics, mathematical fundamentals/ numerical simulation, physical fundamentals, and facilities.
New Results in Numerical and Experimental Fluid Mechanics V ; Contributions to the 14th STAB/DGLR Symposium Bremen, Germany 2004
This volume contains the contributions to the 14. Symposium of the STAB (German Aerospace Aerodynamics Association). The volume gives a broad overview over the ongoing work in this field in Germany, with the topics being high-aspect ratio wings, low aspect-ratio wings, bluff bodies, laminar flow control and transition, active flow control, hypersonic flows, aeroelasticity, aeroacoustics, mathematical fundamentals/ numerical simulation, physical fundamentals, and facilities.
New diagnostic method th detect peritoneal metastases in colorectal cancer
Colorectal cancer is the third common reason of death in population worldwide therefore we will focus in our study about description of this type of cancer and its symptoms to raise the public awareness to go to the right specialist as soon as the symptoms appear to improve early detection of this disease and the overall survival and we will highlight the best diet and life style to avoid this type of cancer hopefully beside that we will present all the most successful therapies of this disease from different classes of compounds such as chemotherapy or anti angiogenic and Metformin and other bacterial therapy however the major goal of the experimental part of this research is performed to establish a new promising diagnostic tool by Near Infra-red camera after injection of indyocine green to detection the peritoneal metastasis of colorectal in 15 patients since this kind of metastasis
New Challenges in Superconductivity : Experimental Advances and Emerging Theories ; Proceedings of the NATO Advanced Research Workshop, held in Miami, Florida, 11-14 January 2004
This volume contains the proceedings of the 2004 University of Miami Workshop on Unconventional Superconductivity. The workshop was the fourth in a series of successful meetings on High-T Superconductivity and C related topics, which took place at the James L. Knight Physics Building on the University of Miami campus in Coral Gables, Florida, in January 1991, 1995, 1999, and 2004. The workshop consisted of two consecutive events: 1. NATO Advanced Research Workshop (ARW) on New Challenges in Superconductivity: Experimental Advances and Emerging Theories, held on January 11-14, 2004; 2. Symposium on Emerging Mechanisms for High Temperature Superconductivity (SEMHTS), held on January 15-16, 2004.
Neurotransmitter Transporters
The present volume of the Handbook of Experimental Pharmacology gives a representative survey of the current status of the structure, function, regulation and molecular pharmacology of Neurotransmitter Transporters and aims at providing an overview of insights that were generated in the past 5 years. If the volume serves as both, a useful compendium of current concepts and an inspiring starting point, it will have fulfilled its mission and will be a source for students interested in this emerging field as well as for experienced scientists looking for an update. This volume is the brainchild of the editor-in-chief of the HEP series, Klaus Starke, awe-inspiring to all pharmacologists of younger generations.
Neurodynamics of Cognition and Consciousness
This book addresses dynamical aspects of brain functions and cognition. This volume gives an overview of recent advances in this interdisciplinary field of cognitive and computer science related to dynamics of cognition, including experimental studies, dynamical modelling and interpretation of cognitive experiments, and theoretical approaches.
