الصفحة 1
الصفحة 1
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
On the Way to the Web : The Secret History of the Internet and its Founders
On the Way to the Web: The Secret History of the Internet and Its Founders is an absorbing chronicle of the inventive, individualistic, and often cantankerous individuals who set the Internet free. Michael A. Banks describes how the online population created a new culture and turned a new frontier into their vision of the future. This book will introduce you to the innovators who laid the foundation for the Internet and the World Wide Web, the man who invented online chat, and the people who invented the products all of us use online every day. Learn where, when, how and why the Internet came into being, and exactly what hundreds of thousands of people were doing online before the Web. See who was behind it all, and what inspired them.
Object-oriented metrics in practice : Using software metrics to characterize, Evaluate, and Improve the design of object-oriented systems
The combination of theoretically sound results and practically tested procedures and solution paths makes this book an ideal companion for professional software architects, developers and quality engineers. The pattern-oriented description of disharmonies offers easy access to detecting shortcomings and applying solution strategies. "This well-written book is an important piece of work that takes the seemingly forgotten art of object-oriented metrics to the next level in terms of relevance and usefulness."
Novepernove : Sudoku : segreti e strategie di gioco = Novepernove : Sudoku : game secrets and strategies
The game of Sudoku has exploded in the Western world since 2005 and has since continued to expand, to gather new followers, to proliferate specialized magazines on newsstands and dedicated sites on the Internet. Sudoku success shows no signs of slowing down. All the major newspapers offer daily some patterns to be solved; associations and federations were born; local tournaments, various national championships and even an annual world championship are organized; the proposals for variants of the classic Sudoku multiply; many university professors have launched graduate theses on the subject; various software products have been written on PCs, on dedicated hardware and on the main interactive game consoles.
Novel Optical Resolution Technologies
After theend ofthe 20th century, the science ofcrystallizationreached a truly exciting stage where new opportunities emerged in both theory and expe- ment. Variousphysical methodsare capable of resolving the surface as wellas the insid estructure of crystalsat the atomiclevel while newhigh-performance computing resourcesafford thecapability of modeling the complexlarge-scale alignments necessary to simulatecrystallizationinrealsystems. Asaresult, the science of crystallization has shifted gradually fromstatic to dynamic science and considerable progress now underlies the complex but beautiful cryst- lization process.The vastpotential ofcrystallizationasan- portant feld ofscience isfar beyondthesimple technologyofpharmaceutical industries during the 20th century.
Nine algorithms that changed the future : The ingenious ideas that drive today’s computers
Every day, we use our computers to perform remarkable feats. A simple web search picks out a handful of relevant needles from the world’s biggest haystack. Uploading a photo to Facebook transmits millions of pieces of information over numerous error-prone network links, yet somehow a perfect copy of the photo arrives intact. Without even knowing it, we use public-key cryptography to transmit secret information like credit card numbers, and we use digital signatures to verify the identity of the websites we visit. How do our computers perform these tasks with such ease?
New technical approaches and medications to improve fertility for women in Syria
Egg freezing is one way of preserving a woman's fertility so she can try to have a family in the future. It involves collecting a woman's eggs, freezing them and then thawing them later on so they can be used in fertility treatment. Egg freezing won't lower your ovarian reserve and won't decrease your chances of getting pregnancy naturally in the future. To understand why, we will first of all focus on the ovulation process. During each menstrual cycle—typically each month—one egg makes it through the whole ovulatory process, and we will discuss all the reasons which may suggest to do such a specific process in women such as being in malignant diseases and the risk of its side effects of this therapy on fertility for example this medication or radiation therapy mainly in a abdomen area is reducing fertility beside other types of medications mentioned in this research
New Methodologies and Techniques for a Sustainable Organic Chemistry
Chemical industries have to face the big challenge of finding adequate processes to produce large quantities of new products for which there is a present need, decreasing at the same time both the impact on the environment and the risk of disasters. These issues have led to the establishment of new concepts of sustainable development as affirmed in the Rio Declaration on Environment and Development in the early 90’s and has been the subject of intensive studies in the last two decades. The book addresses this challenge collecting the recent “New Methodologies and Techniques for a Sustainable Organic Chemistry”.
Natural Skincare Cosmetics
Aging skin is suffering of decrease pigment-containing cells and overproduction of melanin in the skin, also changes in the connective tissue reduce the skin's strength and elasticity. Over the last 20 years, clinical and laboratory studies have identified the benefits of an array of natural ingredients for skin care. A variety of skin care products exist in today’s marketplace. They fulfill a variety of functions by either acting directly on the skin (e.g., moisturizers) or being a cosmetically elegant vehicle for the delivery of specific active ingredients (e.g., sunscreens or antipruritic or antiacne medicaments). Certain ingredients used in cosmeceuticals may be claimed to be therapeutic for common skin diseases. These ingredients are regulated as over the counter (OTC) drug monographs for acne, dermatitis/psoriasis, skin protectant, topical analgesia and sunscreens, by the Food and Drug Administration (FDA)
Narrating China's Governance : Stories in Xi Jinping's Speeches
This book captures and elaborates on the skill of storytelling as one of the distinct leadership features of Xi Jinping, the General Secretary of the Communist Party of China and the President of the People’s Republic of China.
Nanoscaled Semiconductor-on-Insulator Structures and Devices
This proceedings volume constitutes an archive of the contributions of the key-speakers who attended the NATO Advanced Research Workshop on “Nanoscaled Semiconductor-On-Insulator Structures and devices” held in the Tourist and Recreation Centre “Sudak” (Crimea, Ukraine) from 15 to 19 October 2006. The semiconductor industry has sustained a very rapid growth during the last three decades through impressive technological developments which have resulted in products with higher performance and lower cost per function. After many years of development it is now confidently predicted that semiconductor-on-insulator materials will enter and increasingly be used by manufacturing industry. The wider use of semiconductor (es- cially silicon) on insulator materials will not only enable the benefits of these materials to be demonstrated but, also, will drive down the cost of substrates which, in turn, will stimulate the development of other novel devices and applications.
Multiscale processes in the earth’s magnetosphere : From interball to cluster ; Proceedings of the NATO ARW on Multiscale Processes in the Earth's Magnetosphere: From Interball to Cluster, Prague, Czech Republic from 9 to 12 September 2003
The past forty years of space research have seen a substantial improvement in our understanding of the Earth’s magnetosphere and its coupling with the solar wind and interplanetary magnetic ?eld (IMF). The magnetospheric str- ture has been mapped and major processes determining this structure have been de?ned. However, the picture obtained is too often static. We know how the magnetosphere forms via the interaction of the solar wind and IMF with the Earth’s magnetic ?eld. We can describe the steady state for various upstream conditions but do not really understand the dynamic processes leading from one state to another. The main dif?culty is that the magnetosphere is a comp- cated system with many time constants ranging from fractions of a second to days and the system rarely attains a steady state. Two decades ago, it became clear that further progress would require multi-point measurements. Since then, two multi-spacecraft missions have been launched — INTERBALL in 1995/96 and CLUSTER II in 2000. The objectives of these missions d- fered but were complementary: While CLUSTER is adapted to meso-scale processes, INTERBALL observed larger spatial and temporal scales. However, the number of papers taking advantage of both missions simul- neously is rather small.
Multi-scale Modelling for Structures and Composites
Numerous applications of rod structures in civil engineering, aircraft and spacecraft confirm the importance of the topic. On the other hand the majority of books on structural mechanics use some simplifying hypotheses; these hypotheses do not allow to consider some important effects, In this connection the asymptotic analysis of equations of mathematical physics, the equations of elasticity in rod structures (without these hypotheses and simplifying assumptions being imposed) is undertaken in the present book.
Multiple Stressors : A Challenge for the Future
This book publishes the Proceedings of the NATO Advanced Research Workshop on Multipollution Exposure and Risk Assessment, Ecotoxiclogical risk from multiple stressors covers any situation where org- isms are exposed to a combination of environmental stressors. These include physical and chemical pollutants as well as other stressors such as parasites and environmental impact (e. g. , climate change or habitat loss). The combi- tion of stressors can result in increased risk to organisms (either additive or synergistic effects) or decreased effects (protective or antagonistic effects). The multiple stressor challenge is an international, multi-disciplinary problem requiring an international, multi-disciplinary approach. The c- rent approach to multiple stressors is to examine one stressor at a time and assume additivity.
Multimedia Encryption and Watermarking
Multimedia Encryption and Watermarking presents a comprehensive survey of contemporary multimedia encryption and watermarking techniques, which enable a secure exchange of multimedia intellectual property. Part I, Digital Rights Management (DRM) for Multimedia, introduces DRM concepts and models for multimedia content protection, and presents the key players. Part II, Multimedia Cryptography, provides an overview of modern cryptography, with the focus on modern image, video, speech, and audio encryption techniques. This book also provides an advanced concept of visual and audio sharing techniques. Part III, Digital Watermarking, introduces the concept of watermarking for multimedia, classifies watermarking applications, and evaluates various multimedia watermarking concepts and techniques, including digital watermarking techniques for binary images. Multimedia Encryption and Watermarking is designed for researchers and practitioners, as well as scientists and engineers who design and develop systems for the protection of digital multimedia content. This volume is also suitable as a textbook for graduate courses on multimedia security.
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Molecular Biology of the Parathyroid
Caintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic hypocalcemia leads to hypertrophy and hyper plasia of the parathyroid gland together with increased production of the hormone. Phosphate is also a key modulator of PTH secretion, gene expres sion and parathyroid cell proliferation. Understanding the biology of the parathyroid as well as the mecha nisms of associated diseases has taken great strides in recent years. This book summarizes the molecular mechanisms involved in the function of the para thyroid gland. The first chapter reviews the development of the parathyroid gland and the genes involved in this process as identified using genetically manipulated mice. Then the biosynthetic pathway of PTH from gene ex pression to its intracellular processing and the sequences in the gene control ling its transcription as well as those regulating mRNA processing, stability and translation are described.
Modern treatments for chronic blood diseases
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloida osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). Thalassemias are inherited blood disorders characterized by decreased hemoglobin production Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
Modern cryptography ; Vol.1 : A classical introduction to informational and mathematical principle
This book systematically explores the statistical characteristics of cryptographic systems, the computational complexity theory of cryptographic algorithms and the mathematical principles behind various encryption and decryption algorithms. The theory stems from technology. Based on Shannon's information theory, this book systematically introduces the information theory, statistical characteristics and computational complexity theory of public key cryptography, focusing on the three main algorithms of public key cryptography, RSA, discrete logarithm and elliptic curve cryptosystem.
Modern aspects of pharmaceutical quality assurance : developing and proposing application models, SOPs, practical audit systems for pharma industry
Aims to develop a tool that will substantially decrease the number of Inspectional Observations and Warning letters, thus eliminating Import Alerts and Consent Decree. This book targets the Pharmaceutical Industry and students of Pharmaceutical Quality Assurance so they can get in hand-ready consolidated information on Pharmaceutical Quality guidelines, Quality metrics, and implementation of simplified SOP guidelines, plant layouts to implement Quality metrics for Pharmaceutical Manufacturing systems in tablets, capsules, liquid orals, and semi-solid dosage forms.
