الصفحة 1
الصفحة 1
Ranunculales medicinal plants : Biodiversity, chemodiversity and pharmacotherapy ; 1st ed.
Covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource.
Pharmaco-complexity : Non-Linear Phenomena and Drug Product Development
Non-linear phenomena pervade the pharmaceutical sciences. Understanding the interface between each of these phenomena and the way in which they contribute to overarching processes such as pharmaceutical product development may ultimately result in more efficient, less costly and rapid implementation. The benefit to Society is self-evident in that affordable treatments would be rapidly forthcoming
Personalized medicine
The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. There is a growing attention towards personalized medicine. This is led by a fundamental shift from the ‘one size fits all’.. (Every year in the USA 2 million people die due to adverse drug effects, Drug efficacy is only in 60 % of the population - Other 40 % have poor drug effects or no effect at all ) paradigm for treatment of patients with conditions or predisposition to diseases, to one that embraces novel approaches, such as tailored target therapies, to achieve the best possible outcomes.
Nanotechnology in therapeutics : Basics and trends
Nanotechnology delivers a unique approach, which promises higher drug efficacy, targeted drug delivery, on demand delivery, biocompatibility, etc. For example, nanotechnology-based delivery systems can protect drugs from degradation and help reduce the number of doses required, make treatment a better experience and reduce treatment expenses and a number of nano-based systems allow delivery of insoluble drugs, allowing the use of previously rejected drugs or drugs which are difficult to administer.
Imaging in Drug Discovery and Early Clinical Trials
Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation.
Drug transporters : Molecular characterization and role in drug disposition
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
