الصفحة 1
الصفحة 1
Molecular Genetics of Recombination
Genetic recombination is an important process involved in shaping the genetic make up of progeny. Increasingly, it has become evident that recombination is a DNA repair pathway crucial during DNA replication in vegetatively growing cells.
Hormonal control of cell cycle
This volume reflects the proceedings of an International Workshop held in Paris in December 2006. The aim of the meeting was to undertake a high level of scholarly exchange between experts in cell biology, oncology and endocrinology interested in cell cycle control. The topics covered ranged from fundamental studies of DNA replication,chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression.
Genome integrity : Facets and perspectives
The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
DNA manipulation and analysis
Details technologies on recombinant DNA and nucleic acid manipulation that underpin much of the biological sciences and instructions on how to conduct them successfully. Chapters guide the reader through the basics of oligonucleotide synthesis and DNA sequencing; recombinant DNA plasmid work; cell-free experiments and the latest developments in CRISPR approaches to genome modification.
Chromatin Dynamics in Cellular Function
This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.
Cell and Molecular Biology of Plastids
The present book provides a comprehensive overview of our current knowledge on plastid biogenesis, plastid-nuclear communication, the regulation of plastid gene expression at all levels, and also assesses the state of the art in key technologies, such as proteomics and chloroplast transformation. Written by recognized experts in the field, it covers plastid differentiation and division, genome structure and function, plastid inheritance, recombination, DNA replication and repair, transcription, RNA processing and translation as well as crucial posttranslational processes in plastid biogenesis and function, including protein processing, the assembly of multiprotein complexes, protein stability and degradation, protein import and sorting.
Bacteriophage therapy : a potential solution for antibiotic resistance crisis
For many years, humans have been fighting with bacteria, in a matter of fact, bacteria have been winning for the last decade, becoming resistant to every weapon we have; The antibiotics. In order to win the fight humans had to think of alternative ways, like viruses. There is a special type of viruses that have been in a war with bacteria for millenniums, Bacteriophages. Bacteriophages (or phages), the most abundant viral entity of the planet. On the basis of their unique characteristics and anti-bacterial property, phages are being the freshly evaluated taxonomically. Phages replicate inside the host either by lytic or lysogenic mode after infecting and using the cellular machinery of a bacterium. Phage became an important agent for combating pathogenic bacteria in clinical treatments and its related research gained momentum. However, due to recent rise of bacterial resistance on antibiotics, applications of phage (phage therapy) become an unavoidable option of research. In this dissertation, the advantage and limitations of Bacteriophages for use in humans will be discussed. Furthermore, this dissertation deals with recent development of its application in the areas of biotechnology.
