الصفحة 1
الصفحة 1
Novel mouse model for future autism research
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the first 3 years of life. It is not a single disorder, and it is broadly considered to be a multi-factorial disorder resulting from genetic and non-genetic risk factors and their interaction. Genetic studies of ASD have identified mutations that interfere with typical neurodevelopment in utero through childhood. These complexes of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have provided many important insights into the pathological changes that occur in the brain of patients with ASD in vivo. Especially, the role of amygdala, a major component of the limbic system and the affective loop of the cortico-striatothalamo-cortical circuit, in cognition and ASD has been proved in numerous neuropathological and neuroimaging studies.
Nonsmooth Mechanics and Analysis : Theoretical and Numerical Advances
Nonsmooth mechanics concerns mechanical situations with possible nondifferentiable relationships, eventually discontinuous, as unilateral contact, dry friction, collisions, plasticity, damage, and phase transition. The basis of the approach consists in dealing with such problems without resorting to any regularization process. Indeed, the nonsmoothness is due to simplified mechanical modeling; a more sophisticated model would require too large a number of variables, and sometimes the mechanical information is not available via experimental investigations. Therefore, the mathematical formulation becomes nonsmooth; regularizing would only be a trick of arithmetic without any physical justification. Nonsmooth analysis was developed, especially in Montpellier, to provide specific theoretical and numerical tools to deal with nonsmoothness. It is important not only in mechanics but also in physics, robotics, and economics.
Nonlinear Oscillations in Mechanical Engineering
Nonlinear Oscillations in Mechanical Engineering explores the effects of nonlinearities encountered in applications in that field. Since the nonlinearities are caused, first of all, by contacts between different mechanical parts, the main part of this book is devoted to oscillations in mechanical systems with discontinuities caused by dry friction and collisions.
Nonlinear kalman filtering for force-controlled robot tasks
This monograph focuses on how to achieve more robot autonomy by means of reliable processing skills. "Nonlinear Kalman Filtering for Force-Controlled Robot Tasks " discusses the latest developments in the areas of contact modeling, nonlinear parameter estimation and task plan optimization for improved estimation accuracy.
Music as Intangible Cultural Heritage : Economic, Cultural and Social Identity
Our first contact with music is almost certainly in our childhood when our parents sing lullabies to us at bedtime. In a community where music is important, these songs are likely to be successfully transmitted from one generation to the next. This is similar to the concept of intangible cultural heritage and how it is transmitted.
Multiscale Biomechanics and Tribology of Inorganic and Organic Systems : In memory of Professor Sergey Psakhie
This book gathers authoritative contributions concerning multiscale problems in biomechanics, geomechanics, materials science and tribology. It is written in memory of Sergey Grigorievich Psakhie to feature various aspects of his multifaceted research interests, ranging from theoretical physics, computer modeling of materials and material characterization at the atomic scale, to applications in space industry, medicine and geotectonics, and including organizational, psychological and philosophical aspects of scientific research and teaching as well
Multi-point Interaction with Real and Virtual Objects
This edited book covers some of the most challenging problems on the forefront of today’s research on physical interaction with real and virtual objects, with special emphasis on modelling contacts between objects, grasp planning algorithms, haptic perception, and advanced design of hands, devices and interfaces.
Multilingualism, Cultural Identity, and Education in Morocco
This book is an original contribution to the field of multilingualism and cultural identity. It investigates the ramifications of multilingualism for language choice patterns and attitudes among Moroccans. It focuses on the impact of multilingualism on cultural identity and education. It includes a debate on education and language planning policies in Morocco since independence. It reveals the complexity of post-colonial Morocco characterized by contradictory attitudes toward the languages in contact and toward language policy and education. It is of interest to students and researchers of sociolinguistics, cultural studies, anthropology and gender studies as well as for specialists of education and language policy/planning.
Multilevel Block Factorization Preconditioners : Matrix-based Analysis and Algorithms for Solving Finite Element Equations
This monograph is the first to provide a comprehensive, self-contained and rigorous presentation of some of the most powerful preconditioning methods for solving finite element equations in a common block-matrix factorization framework. Topics covered include the classical incomplete block-factorization preconditioners and the most efficient methods such as the multigrid, algebraic multigrid, and domain decomposition. Additionally, the author discusses preconditioning of saddle-point, nonsymmetric and indefinite problems, as well as preconditioning of certain nonlinear and quadratic constrained minimization problems that typically arise in contact mechanics. The book presents analytical as well as algorithmic aspects.
Multibody Dynamics : Computational Methods and Applications
This book contains the revised and extended versions of selected conference communications, representing the state-of-the-art in the advances on computational multibody models, from the most abstract mathematical developments to practical engineering applications. This book will be highly valuable for experienced researchers that want to keep updated on the details of the latest driving ideas in this field. It will also be of interest to researchers approaching the field for the first time, since it provides a useful overview of the most active areas and the efforts devoted by many prominent research groups worldwide.
Motion Planning in Medicine : Optimization and Simulation Algorithms for Image-Guided Procedures
The monograph written by Ron Alterovitz and Ken Goldberg combines ideas from robotics, physically-based modeling, and operations research to develop new motion planning and optimization algorithms for image-guided medical procedures. A challenge clinicians commonly face is compensating for errors caused by soft tissue deformations that occur when imaging devices or surgical tools physically contact soft tissue. A number of methods are presented which can be applied to a variety of medical procedures, from biopsies to anaesthesia injections to radiation cancer treatment. They can also be extended to address problems outside the context of medical robotics, including nonholonomic motion planning for mobile robots in field or manufacturing environments.
Monographs in contact allergy ; Vol.4 : Systemic drugs
Presents : Identification section; Occupational allergic contact dermatitis; and Cutaneous adverse drug reactions from systemic drugs caused by type IV (delayed-type) hypersensitivity, as shown by positive patch tests (e.g. maculopapular eruption, acute generalized exanthematous pustulosis [AGEP], symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], fixed drug eruption, drug reaction with eosinophilia and systemic symptoms [DRESS], and photosensitivity). Separate chapters present an overview of the spectrum of allergic cutaneous drug reactions, diagnostic tests, immediate contact reactions (contact urticaria), and systemic drugs that have acquired delayed-type hypersensitivity only by cross-reactivity.
Molecular recognition in pharmacology
Traces the behavior of the drug substance, starting from the initial pre-contact stage, and ending with the formation of the complex. Molecular recognition lies in the foundation of every life form and includes many mysteries. Currently, studies on this topic in pharmacology are limited to determining the properties of complexes of medicinal substances (drugs) with specific (complementary) biomolecules: receptors, enzymes, ion channels etc. The results present the mechanisms preventing drugs from such non-specific binding. This direction is very fruitful, although the phenomenon of molecular recognition is far wider.
Molecular Mechanisms of Synaptogenesis
Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders. In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.
Molecular Mechanisms of Phagocytosis
Although, Phagocytosis was first described nearly 120 year ago, we are just recently beginning to understand the molecules that phagocytic cells use to bring about this complex cell function. Molecular Mechanisms of Phagocytosis was prepared as a series of up-to-date essays (chapters) that describe the present knowledge on the various steps of the phagocytic process from initial cell contact, through internalization of the foreign particle, to the final phagosome formation where the phagocytosed particle is destroyed.
Modeling Communication with Robots and Virtual Humans ; Second ZiF Research Group International Workshop on Embodied Communication in Humans and Machines, Bielefeld, Germany, April 5-8, 2006, Revised Selected Papers
The 17 articles in this state-of-the-art survey address artificial intelligence research on communicative agents and also provide an interdisciplinary perspective from linguistics, behavioral research, theoretical biology, philosophy, communication psychology, and computational neuroscience. The topics include studies on human multimodal communication; the modeling of feedback signals, facial expression, eye contact, and deception; the recognition and comprehension of hand gestures and head movements; communication interfaces for humanoid robots; the evolution of cognition and language; emotion and social appraisal in nonverbal communication; dialogue models and methodologies; theory of mind and intentionality; complex systems, dynamic field theory, and connectionist modeling.
Microscopy of Semiconducting Materials 2007 ; Proceedings of the 15th Conference, 2-5 April 2007, Cambridge, UK
The conference focused upon the most recent advances in the study of the structural and electronic properties of semiconducting materials by the application of transmission and scanning electron microscopy, scanning probe microscopy and X-ray-based methods. Conference sessions concentrated on key topics including state-of-the-art studies in high resolution imaging and analytical electron microscopy, advanced scanning probe microscopy, scanning electron microscopy and focused ion beam applications, novel epitaxial layer phenomena, the properties of quantum nanostructures, III-nitride developments, GeSi/Si for advanced devices, metal-semiconductor contacts and silicides and the important effects of critical device processing treatments.
Micromechanics of Contact and Interphase Layers
Micromechanics provides a link between the structure and the properties at different scales of observation. This book deals with micromechanical analysis of interfaces and interface layers and presents several modelling tools, ranging from the rigorous method of asymptotic expansions to practical finite element simulations, suitable for this class of problems. Two application areas are discussed. Boundary layers associated with contact of rough bodies are modelled by applying a scale transition approach in which a macroscopic interface of zero thickness is seen at the micro-scale as a layer with some finite thickness. Secondly, evolution of laminated microstructures accompanying stress-induced martensitic transformations in shape memory alloys (SMA) is analyzed as an illustration of the case when the local interfacial phenomena – here the propagation of phase transformation fronts – govern the macroscopic behaviour of a heterogeneous material.
Mental health disorders in pregnancy and the early postpartum
Mental health disorders are common in pregnancy and after childbirth with over 10% of women manifesting some form of mental illness during this time. Maternity services will encounter women with symptoms that vary in severity from mild self-limiting to potentially life-threatening. These conditions carry risks for both the woman and the fetus/newborn. Detecting women with, or at risk of, a serious mental health disorder and enabling them to access appropriate care in a timely fashion is a shared responsibility. However, given the frequency of contact they have with women through this period, maternity services have a pivotal role. From a mental health perspective, high-risk pregnancies are those primarily associated with serious mental illness (psychotic illnesses, bipolar disorder and severe depressive episodes). Healthcare professionals caring for pregnant women should have the appropriate skills to detect serious mental illness and identify women at risk and how to access specialist mental health care.
McCracken's removable partial prosthodontics
Walks readers through all the principles and concepts surrounding removable partial denture treatment planning and design that today’s practitioners need to know. Using an evidence-based approach, this full-color text incorporates the latest information on new techniques, procedures, and equipment, including expanded information on dynamic communication and the use of implants with removable partial dentures. From initial contact with the patient to post-treatment care, McCracken’s is the complete foundation today’s dentists need to successfully practice prosthodontic care.
