الصفحة 1
الصفحة 1
Obesity and Cancer
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development.
Neglected tropical diseases and phytochemicals in drug discovery
Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.
Natural products and human diseases : Pharmacology, molecular targets, and therapeutic benefits
Provides insight into the clinical and translational application of natural products in human diseases Details the impact of natural products on a molecular basis Describes the identification of biomarkers, therapeutic effects of phytochemicals, and and new targets
Natural product experiments in drug discovery
Explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.
Nanotechnology-Enabled Sensors
Nanotechnology provides us with tools to create functional materials, devices, and systems by controlling materials at the atomic and molecular scales, and at the same time make use of novel properties and phenomena. Considering that most chemical and biological sensors, as well as many physical sensors, depend on interactions occurring within the nano scale range, the impact that nanotechnology will have on the sensor world is significant. Nanotechnology enabled sensors find applications in several novel fields such as sensing single molecules, bio-hazards, toxic chemicals, gas sensors, process control and diagnostics.
Nanotechnology for Environmental Remediation
The newly discovered advanced oxidation technology using nanoscale zero-valent iron, which is reported in this book, could be widely used to treat pesticides, herbicides, and industrial chemicals as well as to purify contaminated water for domestic use. In addition, it can contribute to advancing science and technology and providing valuable information to all readers - researchers, scientists, engineers, and students - in this field for their further research and studies.
Nanophytomedicine : An emerging platform for drug delivery
Covers recent advances in experimental and theoretical studies on various properties of nanoparticles derived from plant sources. This book assesses the recent advancements and applications of plant-based nanoparticles and also highlights emerging concepts of biomimetics. Contains 24 chapters encompassing various therapeutic applications of phytochemicals derived from plants, ferns, seaweeds, and so on, mediated through nanotechnology and its allied approaches. A fervent attempt has been made to compile every significant advancement in the field of phytonanomedicine so as to accelerate its momentum in the pharmaceutical sector.
N-Acetylaspartate : A Unique Neuronal Molecule in the Central Nervous System
N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.
Multicomponent reactions towards heterocycles : Concepts and applications
Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs.
Mucins : Methods and protocols
Explores the latest advancements in mucin research. The chapters in this book are organized into 8 parts and cover a wide range of topics such as mucin extraction, isolation, physicochemical property analysis, and experimental methods. The chapters also discuss the origins of mucins in jellyfish, feces, saliva and salivary glands, bronchi, stomach, and cervical tract; organic synthesis of peptides glycosylated at specific sites; analysis of mucin gene expression and methylation-specific electrophoresis of genes; imaging of mucin networks by AFM; and experimental methods using supported molecular matrix electrophoresis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Monitors of Organic Chemicals in the Environment : Semipermeable Membrane Devices
Modern, industrialized societies depend on a wide range of chemical substances such as fuels, plastics, biocides, pharmaceuticals and detergents for maintaining the high quality lifestyle to which we aspire. The challenge is to ensure that while we enjoy the benetsof thes esubstances,theirinevitablereleaseintoourbiosphere does not result in unwanted human and ecosystem exposures, and the risk of - verse effects. One response to this challenge has been the extensive effort to detect and analyze or monitor a multitude of chemicals in a variety of environmental media, especially toxic organic compounds in air, water, soils and biota. An extensive literature on these traditional techniques has evolved over the years.
Molecular Biology in Plant Pathogenesis and Disease Management : Disease Management ; Vol.3
Exclusion and eradication of plant pathogens by rapid and precise detection and identification of microbial pathogens in symptomatic and asymptomatic plants and planting materials by employing molecular methods has been practiced extensively by quarantines and certification programs with a decisive advantage. Identification of sources of resistance genes, cloning and characterization of desired resistance genes and incorporation of resistance gene(s) into cultivars and transformation of plants with selected gene(s) have been successfully performed by applying appropriate molecular techniques. Induction of resistance in susceptible cultivars by using biotic and abiotic inducers of resistance is a practical proposition for several crops whose resistance levels could not be improved by breeding or transformation procedures. The risks of emergence of pathogen strains less sensitive or resistant to chemicals have been reduced appreciably by rapid identification of resistant strains and monitoring the occurrence of such strains in different geographical locations.
Modern medicines from plants : Botanical histories of some of modern medicine’s most important drugs
Features information on plants from which we obtain modern prescription medicines. It outlines their historical uses as herbal medicines in the past two millennia, using primary sources, and describes how extracts from them, and their semisynthetic and synthetic derivatives, were developed to be today’s therapeutic drugs and diagnostic chemicals. This book describes medicinal plants and their habitats, the diseases that their medicines treat, and the science of how they work.
Metal Catalyzed Reductive C-C Bond Formation : A Departure from Preformed Organometallic Reagents
The prototypical catalytic reductive C–C bond formations, the Fischer-Tropsch reaction [1] and alkene hydroformylation [2], were discovered in 1922 and 1938, respectively [3,4]. These processes, which involve reductive coupling to carbon monoxide, have long been applied to the industrial manufacture of commodity chemicals [5]. Notably, alkene hydroformylation, also known as the oxo-synthesis, has emerged as the largest volume application of homogeneous metal catalysis, accounting for the production of over 7 million metrictons of aldehyde annually. Despite the impact of these prototypical reductive C–C bond formations, this field of research lay fallow for several decades.
Integrated Urban Water Resources Management
Growing populations and rising standards of living exert stress on water supply and the quality of drinking water. In wastewater management, new challenges are caused by new chemicals of concern, including endocrine disrupters, pharmaceuticals, hormones, and personal care products, which often pass through wastewater treatment plants unabated, but may cause serious impacts on receiving aquatic ecosystems. Advanced wastewater treatment leads to production of biosolids, which are processed in various ways, including on-land applications in agriculture. Municipal effluents, combined with increasing withdrawals of water, lead to the worsening of receiving water quality. Expert opinions indicate that the only way to deal with the current urban water management dilemmas is by integrated management and innovative delivery of water services. This book presents important aspects of Challenges in Management of Urban Water Resources, Challenges in Urban Water Supply, Urban Drainage and Water Bodies, Wastewater Treatment and Security, and Wastewater Treatment and Reuse.
Indicator Systems for Sustainable Innovation
In the recent past, environmental innovations have led to a considerable reduction of many pollutants; however, further innovation is required to tackle remaining pollution sources. This work analyses the significance and the effects of framework conditions on innovation activities that contribute to the realisation of a sustainable development. The book links the experiences of different research projects with the aim to develop a system of indicators to evaluate sustainable effects of (environmental) innovations. A comprehensive framework for an indicator system is established that allows to include different environmental innovation fields such as process innovations in the steel production, substitution of dangerous chemicals, organisational innovations in the field of waste disposal or sustainable water management.
High value fermentation products ; Vol.1 : Human health
This book describes relevant aspects of industrial-scale fermentation, an expanding area of activity, which already generates commercial values of over one third of a trillion US dollars annually, and which will most likely radically change the way we produce chemicals in the long-term future. From biofuels and bulk amino acids to monoclonal antibodies and stem cells, they all rely on mass suspension cultivation of cells in stirred bioreactors, which is the most widely used and versatile way to produce.
Herbal medicine in India : Indigenous knowledge, practice, innovation and its value
Covers Indian herbal medicines, health products, pharmaceuticals, nutraceuticals, and cosmetics. Highlights the status quo and future prospects of traditional medicine in India / Provides information on drug discovery, ethnobotany, isolation of phytochemicals, importance of herbal nutraceuticals, etc. / Covers innovation, validation and IPR issues related to Indian traditional medicine
Hazardous Chemicals in Products and Processes : Substitution as an Innovative Process
ubstitution of hazardous substances is a prioritised objective in chemical regulation and risk management. However, it is experienced as a tough task with often inconsistent results. Based on thirteen case studies, this book analyzes substitution as an innovation process and attempts to give answers to the following questions: Why and under which circumstances are companies able and willing to substitute hazardous substances? What are the main drivers and the main barriers? In which way can communication along the supply chain support environmental innovation? How can risk management appropriately deal with the lack of knowledge, with uncertainties and incomplete knowledge about the possible effects of different substances?
Handbook of oleoresins : Extraction, characterization, and applications
This is a snapshot of information on oleoresins—production, composition, properties, applications (medicinal & health properties), and more. It is designed to be a practical tool for the various professionals who develop and market spices and oleoresins
