الصفحة 1
الصفحة 1
The EBMT Handbook : Hematopoietic Stem Cell Transplantation and Cellular Therapies
Addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies.
The EBMT handbook : Hematopoietic cell transplantation and cellular therapies
Addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. Consisting of 94 chapters, it has been written by 210 leading experts in the field. Discussing all types of hematopoietic cell transplantation, including selection of stem cell sources, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies and new infections (COVID-19).
Symmetry in modeling and analysis of dynamic systems
Real-world systems exhibit complex behavior, therefore novel mathematical approaches or modifications of classical ones have to be employed to precisely predict, monitor, and control complicated chaotic and stochastic processes. One of the most basic concepts that has to be taken into account while conducting research in all natural sciences is symmetry, and it is usually used to refer to an object that is invariant under some transformations including translation, reflection, rotation or scaling.The following Special Issue is dedicated to investigations of the concept of dynamical symmetry in the modelling and analysis of dynamic features occurring in various branches of science like physics, chemistry, biology, and engineering, with special emphasis on research based on the mathematical models of nonlinear partial and ordinary differential equations.
Stroke Recovery with Cellular Therapies
As the leading cause of adult disability, stroke poses substantial economic and psychological burdens to populations around the world. Against this dismal backdrop, several novel "neurorestorative" approaches are being investigated as adjunctive treatments to physiotherapy. Stroke Recovery with Cellular Therapies discusses the promising investigations around the world on cell-based therapies to enhance recovery from stroke. Throughout this groundbreaking text, chapters detail the potential benefits of various types of cells and approaches for ischemic and hemorrhagic stroke, and all studies rely upon traditional histological and functional outcomes. Among the topics detailed in this volume are transplanting immortalized neural stem cells, transplantation of bone marrow stromal cells, adipose-derived stem cells, endogenous neural stem cells in tissue remodeling, and an investigation into the ethics of stem cell research.
Stem cells
Stem cells are undifferentiated or partially differentiated cells that can differentiate into many types of cells and proliferate indefinitely to produce more of the same stem cell. They are the oldest cell type in the cell lineage found in both embryonic and adult organisms, but have slightly different properties in each. They are usually distinguished from progenitor cells that cannot divide indefinitely, and primary cells or blastocytes, which usually adhere to differentiation into a single cell type...
Stem Cell Transplantations Between Siblings as Social Phenomena : The Child’s Body and Family Decision-making
Offers insights in short- and long-term experiences from families with bone marrow transplantations between minor siblings. It is based on the first extended qualitative study with 17 families about experiences with recent transplants and experiences with transplants up to 20 years in the past. It covers reflections of donors, recipients and other family members, as well as family interactions. Transplantation of bone marrow from one sibling to another who is ill with a blood cancer (such as Leukemia) is a life-saving therapy. Young children however are not in a position to give consent themselves. How should they be adequately included, depending to their age? Which ethical questions are raised for the parents both at the time of treatment and afterwards, and for the medical professionals in clinical and regulatory contexts?
Stem Cell and Gene-Based Therapy : Frontiers in Regenerative Medicine
Regenerative medicine - stem cell and gene-based therapy - provides a new clinical approach for restoring function of damaged organs and tissues. There has been incredible progress in experimental strategies for tissue regeneration, particularly in cell transplantation and stem cell research. These have led to potential treatment options for many otherwise fatal conditions, including end-stage organ failure. Cell therapy and tissue engineering of viable grafts could therefore provide prospective new solutions to the serious problems of organ donor shortage.
Regenerative and Cell Therapy : Clinical Advances
This book gives an updated review of the state of the art in regenerative cell therapy in the fields of cardiology, hematology, pediatrics, neurology, orthopedics and infectious diseases. The book emphasizes clinical advances as proof of concept in cell therapy based on the revolutionizing observation that regeneration can occur throughout the body even in highly differentiated organs like the heart and the neuronal system. It provides examples of breakthroughs in the clinical implementation of adult stem cell therapy.
Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy : The JACIE Guide
Provides a concise yet comprehensive overview on how to build a quality management program for hematopoietic stem cell transplantation (HSCT) and cellular therapy. The text reviews all the essential steps and elements necessary for establishing a quality management program and achieving accreditation in HSCT and cellular therapy.
Practical transfusion medicine
Provide a comprehensive guide to transfusion medicine. It contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text. Covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding.
Post-Transplant Lymphoproliferative Disorders
This disorder transcends multiple disciplines and demands a team approach to improve knowledge and treatment. The highly experienced internationally recognized authors have updated every section and added many new chapters, including some on genetic abnormalities in virus and host seen in PTLDs. In this successor edition, there is a completely new section on PTLDs after hematopoietic stem cell transplantation. The newest PTLD classifications and current treatment paradigms that reflect recently conducted international trials are fully incorporated. As technologies have advanced, this book provided state-of-the-art new diagnostic and prognostic information.
Pediatric hematopoietic stem cell transplantation for pharmacists : The gold standard to practice
Addresses subjects such as stem cells and their differentiation mechanisms; aspects of embryonic and non-embryonic stem cells ; stem cell transplantation in pediatrics ; stem cell sources and related technical choices ; stem cell donors ; scheduling transplantations ; diseases and chemotherapy protocols that require stem cell transplantation ; stem cell homing ; engraftment and repopulation of stem cells in bone marrow; autologous stem cell transplantation in pediatrics ; allogeneic stem cell transplantation in pediatrics ; and indications for autologous and allogeneic pediatric stem cell transplantation. Further, it discusses pediatric graft-versus-host disease and the pharmacist ; antibacterial and antifungal prophylaxis ; detailed chemotherapy, conditioning and trials for pediatric stem cell transplantation ; conditioning granulocyte colony-stimulating factor (G-CSF) in pediatric stem cell transplantation ; analyzing prescriptions and programming a pediatric stem cell transplantation ; handling chemotherapy and adjuvant drugs for pediatric stem cell transplantation ; stem cell transplantation in children up to 1 year old ; and clinical pharmacy in pediatric stem cell transplantation.
New strategies in treating and diagnosing of Myeloid Leukemia
Leukemia is a cancer of white blood cells. It is characterized by an abnormal accumulation of WBC in the bone marrow which leads to bone marrow failure. in this project, we will observe myeloid leukemias (acute & chronic), Clinical Practice Guidelines for leukemia provide recommendations on the diagnostic evaluation, and applied treatment in Syria and Germany for induction and consolidation for patients and we're going to devote a special paragraph on therapy with monoclonal antibodies. Gilteritinib are new therapies for acute myeloid leukemia and we're going to suggest them in detail.
Hodgkins and Non-Hodgkins Lymphoma
In this volume, an internationally recognized group of experts provides a comprehensive overview of the biology, pathology, standard treatments, and novel approaches in management of patients across the complex landscape of lymphoma subtypes.
Hematopoietic Stem Cell Transplantation
Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair.
Hematologic Malignancies : Acute Leukemias
Several chapters in this volume describe current knowledge of acute leukemia biology and discuss new classification systems that have arisen consequent to emerging insights into pathogenesis. Treatment has also improved for particular types of acute leukemia.
Filgrastim in clinical oncology : Guarding against neutropenia
Granulocyte colony-stimulating factor (G-CSF) has driven the attention of researchers as a therapeutic agent for curing patients suffering from neutropenia. Despite the successful use of G-CSF, it currently requires daily injections, which are inconvenient, expensive, and distressing for children. Therefore, an alternative strategy for using G-CSF for treatment is needed. Understanding the G-CSF structure, expression, mechanism of action, and how it induces neutrophils mobilization is crucial to producing promising cancer therapy. The ability of G-CSF to mobilize hematopoietic stem cells from the bone marrow into the blood circulation was consequently exploited and altered the practice of hematopoietic stem cell transplantation.
Cytokines and Cancer
This volume provides a comprehensive review of the current knowledge on cytokines and cancer. Cytokines play a variety of roles in cancer, both as components of pathogenetic mechanisms, as well as agents used in the treatment of certain malignancies.The volume is divided in two sections. Section one focuses on current developments in the basic science field with particular emphasis on novel mechanisms of cytokine actions in malignant cells. The second section deals with translational and clinical research in the field, and many of the chapter authors were among the first to introduce several cytokines in the treatment of certain tumors.
Clinical oral medicine and pathology
The book has been well received internationally by a wide audience of clinicians, including general dentists, oral surgeons, otolaryngologists, primary care physicians, nurse practitioners, dental hygienists, physician assistants, and dermatologists, and sales have been strong among students and post-graduate residents training in medical, dental, and allied health fields, supporting the versatility of this work and serving as testimony to its value in both the academic and private practice arenas. Several key updates and improvements have been made to the second edition. All informational content has been updated to ensure accuracy and relevance, particularly in the rapidly evolving fields of oncology and pharmacology. A new chapter has been added entitled "Oral Sequelae of Cancer and Cancer Therapy" which better organizes and consolidates previous content while expanding on topics such as targeted therapies and hematopoietic stem cell transplantation. Additional clinical images have been included throughout the book so that the full clinical spectrum of any given condition is well-represented. Furthermore, the print quality, as well as the positioning and layout of the clinical images has been improved for optimal utility. Lastly, the summary boxes that follow each condition have been reconfigured with color-coded icons for improved definition, ease of use and cross-referencing.
CD4+CD25+ Regulatory T Cells : Origin, Function and Therapeutic Potential
CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues.
