الصفحة 1
الصفحة 1
Oncology : An Evidence-Based Approach
Reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor immunology.
New Trends in Cancer for the 21st Century
It is difficult to imagine anyone who has not heard of cancer. This disease can affect families, friends or any one of us at any time in our lives. Every year nearly 3 million Europeans are diagnosed with cancer, leading to around 800,000 deaths per year. These deaths occur not only in aging populations, but also in children and adults who are in the most active period of their lives. This represents a tremendous problem that cannot be ignored by politicians or citizens. Fortunately, there is a constantly growing awareness that although cancer is a problem to be dealt with by clinicians, it should also be the concern of everyone. This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share here their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view. It can be encouraging to realise that we are not alone in this fight.
New diagnostic method th detect peritoneal metastases in colorectal cancer
Colorectal cancer is the third common reason of death in population worldwide therefore we will focus in our study about description of this type of cancer and its symptoms to raise the public awareness to go to the right specialist as soon as the symptoms appear to improve early detection of this disease and the overall survival and we will highlight the best diet and life style to avoid this type of cancer hopefully beside that we will present all the most successful therapies of this disease from different classes of compounds such as chemotherapy or anti angiogenic and Metformin and other bacterial therapy however the major goal of the experimental part of this research is performed to establish a new promising diagnostic tool by Near Infra-red camera after injection of indyocine green to detection the peritoneal metastasis of colorectal in 15 patients since this kind of metastasis
MRI and CT of the Female Pelvis
MRI and CT exquisitely depict the anatomy of the female pelvis and offer fascinating diagnostic possibilities in women with pelvic disorders. This volume provides a comprehensive account of the use of these cross-sectional imaging techniques to identify and characterize developmental anomalies and acquired diseases of the female genital tract. Both benign and malignant diseases are considered in depth, and detailed attention is also paid to normal anatomical findings and variants. Further individual chapters focus on the patient with pelvic pain and the use of MRI for pelvimetry during pregnancy and the evaluation of fertility. Throughout, emphasis is placed on the most recent diagnostic and technical advances, and the text is complemented by many detailed and informative illustrations.
Molecular Targeting in Oncology
In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice. The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more. Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.
Molecular Pathology of Gynecologic Cancer
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients.
Molecular Pathology in Clinical Practice
This book addresses all areas of molecular pathology clinical practice in a single text, including: molecular biology basics, genetics, infectious diseases, hematopathology, solid tumors, HLA typing, identity testing and laboratory management. This text will provide a comprehensive reference for molecular pathologists as well as the practicing molecular pathologist and trainees.
Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas
apid progress in the understanding of carcinogenesis and pathology of epitheUal skin cancer has led to new strategies for the prevention Rand treatment of these malignancies. The goal of this volume is to comprehensively cover in a highly readable overview our present knowledge of pathogenetic mechanisms and molecular biology of Basal Cell and Squamous Cell Carcinomas. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in epidemiology, histology, photobiology, immunology, cytogenetics, and molecular pathol ogy to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for clinicians and scientists interested in the biology of Basal Cell and Squamous Cell Carcinomas. The chapters are written by authors who are experts in their respective research areas, and I am gratefixl for their willingness to contribute to this book.
Molecular Biology of Human Cancers: An Advanced Student's Textbook
Presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Molecular Basis of Thyroid Cancer
Molecular Basis of thyroid Cancer brings together top-flight experts from across the globe to consider present state of the art treatment and techniques and what the future holds. The product of this effort is invaluable to endocrinologists, particularly those with an interest in the thyroid, molecular oncologists, nuclear medicine physicians and those in biotechnology intent on devising innovative therapies for cancer. "Significant advances in our understanding of thyroid cancer have occurred over the previous decade. This text discusses the molecular alterations and pathologic manifestations seen in this disease. Distinguished investigators address both the basic biology and clinical issues pertinent to our understanding and management of patients with thyroid cancer."
Minimally Invasive Tumor Therapies
In the age of the World Wide Web, informed patients continue to surprise oncologists with detailed questions about popular tumor therapies. Although minimally invasive tumor therapies (MITT) have become daily clinical practice for palliative treatment of liver tumors, the acceptance of these palliative modalities still varies enormously. In addition, promising results have been published for in situ ablation of lung metastases, bone tumors, and renal cell carcinoma. This book gives an up-to-date overview of the popular techniques and clinical results of MITT, with a clarification of the actual indications including the size, tumor entities, and clinical benefits. Moreover, the book focuses on the prospectives and limitations of imaging methods - ultrasound, computed tomography, and magnetic resonance imaging - used for MITT.
Micrometastasis
Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information. In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed. The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.
Microbes and oral squamous cell carcinoma : A network spanning infection and inflammation
Helps in understanding the relationship between microorganisms and oral carcinogenesis, and the possible oncogenic mechanisms enhancing the association. The book highlights the association between oral cancer, primarily oral squamous cell carcinoma (OSCC), a major global health problem with high incidence and low survival rates with infection and inflammation. Establishing the association of the oral microbiome with cancer risk may lead to significant advances in the understanding cancer etiology, potentially opening a new research paradigm for cancer prevention.
Methods of microarray data analysis IV
As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA conference plays a role in this evolving field by providing a forum in which investors can analyze the same data sets using different methods. METHODS OF MICROARRAY DATA ANALYSIS IV is the fourth book in this series, and focuses on the important issue of associating array data with a survival endpoint. Previous books in this series focused on classification (Volume I), pattern recognition (Volume II), and quality control issues (Volume III). In this volume, four lung cancer data sets are the focus of analysis. We highlight three tutorial papers, including one to assist with a basic understanding of lung cancer, a review of survival analysis in the gene expression literature, and a paper on replication. In addition, 14 papers presented at the conference are included. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art of microarray data analysis.
Methods of Cancer Diagnosis, Therapy and Prognosis : Breast Carcinoma
Focusing on Breast Carcinoma, this first volume in the series Methods of Cancer Diagnosis, Therapy and Prognosis brings together 56 leading scientists from around the world to deliver a comprehensive treatise on all aspects of breast cancer, including diagnosis, treatments and prognosis.
Introduzione alla medicina molecolare = Introduction to molecular medicine
An indispensable guide for understanding a young science with rapid and promising developments. Now in its third completely revised edition, it presents in a concise yet comprehensive way the scientific and technological principles of this discipline and provides, in widely accessible language, the basic conceptual tools for understanding the human genome, gene expression and regulation, the various aspects of genetic engineering that allow for the manipulation of DNA, and human cloning.
Intraperitoneal Cancer Therapy
The volume details major clinical trails to date, including immunotherapy, hyperthermic treatment of colo-rectal and ovarian cancers. Authors also examine regional approaches to therapy, systemic therapy, and the use of carboplatin and paclitaxel as the standard treatment for women with stages III and IV ovarian cancer. Other chapters also investigate techniques and procedures in treatment, as well as the future direction of both normothermic and hyperthermic intraperitoneal chemotherapy.
Interventional Management of Urological Diseases
This eighth volume in the series Recent Advances in Endourology brings together the latest clinical findings regarding various endourological treatment modalities and innovative materials. In this book, world-recognized experts outline their techniques clearly and concisely to provide an updated review of state-of-the-art endourological techniques.
Integration / Interaction of Oncologic Growth
The present multi-volume Book Series, CANCER GROWTH AND PROGRESSION, encompasses the widest possible framework of cutting edge research in the field of neoplastic pathology and other integrated fields. The individual volumes in this series focus on the topics of highest scientific interest for basic and clinical researchers, pathologists, medical and surgical oncologists and allied multidisciplinary teams interested in the study of these aspects of neoplastic growth, progression and inhibition. The range of topics covered is extensive.
Imaging of Kidney Cancer
This is one of the first books to deal specifically with diagnostic imaging of the entire spectrum of kidney cancers. Both new and conventional imaging modalities are fully considered. In an introductory chapter, the histopathological classification of kidney cancers is presented and discussed. The following five chapters describe in great detail the abilities, advantages, and disadvantages of the various imaging modalities used in the diagnosis of kidney cancers and the assessment of disease extension. Subsequent chapters offer an exhaustive description of the radiological features of the different histological subtypes of kidney cancer, with radiological and histological illustrations and tables.
