الصفحة 1
الصفحة 1
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
Neuroprotection : Method and protocols
Contains cutting-edge molecular biology methods on neuroprotective mechanisms and specific preclinical models of the CNS injury, iseases and planning translation. Chapters guide readers through neuropathology, neuroprotection, Alzheimer’s disease, amyotrophic lateral sclerosis, ALS, Huntington’s disease , multiple sclerosis, Parkinson’s disease, spinal cord injury, traumatic brain injury, and ischemic brain injury. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Neuro-Oncology of CNS Tumors
Diagnosis and treatment modalities for neuro-oncologic diseases have made considerable advances in recent years. There is hardly a segment of the field of solid tumours that is experiencing such dynamic development with regard to basic scientific findings and clinical results. In the present book the world's leading experts have compiled the current practice-relevant knowledge of neuro-oncologic deseases. The book's clear structure and the uniform presentation of all chapters make this volume a valuable reference, especially for practice-oriented activities, allowing swift access to information about current treatment standards. Hence it will be of great value to both clinicians and researchers.
NEURO-COVID-19 : Neuroinvasive potential and neurological complications of SARS-CoV-2
From the earliest days of the COVID-19 pandemic, there have been reports of significant neurological and psychological symptoms following SARS-CoV-2 infection. This research paper is designed to examine the potential psychoneuroendocrine pathogenic mechanisms by which SARS-CoV-2 elicits psychiatric sequelae, as well as to posit potential pharmacologic strategies to address and reverse these pathologies. Following a brief overview of the presence and prevalence of neuropsychiatric manifestation in COVID-19 patients, we address mechanisms by which SARS-CoV-2 could enter or otherwise elicit changes in the CNS.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
Molecular Neurosurgery with Targeted Toxins
Focuses on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
Modern Anesthetics
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. in this book the very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
Metabolome Analyses : Strategies for Systems Biology
Metabolome Analyses is intended as a follow-up to Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Kluwer, 2003). That text offered guidelines to currently available technology, bioinformatics and databases. Evidence was presented showing metabolic profiling as a valuable addition to genomics and proteomics strategies devoted to drug discovery and development. This book focuses on how metabolic profiling is being more comprehensively integrated with the other "omics" technologies. It provides more practical applications of such "panomics" or "Systems Biology" approaches. The expanding use of mass spectrometry as a measurement technology in metabolic profiling is addressed through demonstrated applications. The integration of metabolic profiling and proteomics is probably most developed for plant-based studies, which was not addressed in Volume 1. Other areas related to metabolic profiling continue to show significant development. These include database strategies and an increased acceptance by the pharmaceutical industry of metabolic profiling. Also covered is the use of in silico metabolic networks. Again the focus is primarily on the pharmaceutical industry but the importance of metabolic profiling to studies on human nutrition (a burgeoning area) is discussed.
Glutamate Receptors in Peripheral Tissue : Excitatory Transmission Outside the CNS
The book is divided into three sections— Part I is on general concepts and concentrates on the distribution and cell-specific localiza tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.
Ethnopharmacology of Medicinal Plants : Asia and the Pacific
This book presents several aspects of the pharmacology, chemistry, botany and folkloric use of selected medicinal plants that can be found in Asia and the Pacific. It is generously illustrated with line drawings for many of the plants under discussion, as well as examples of chemical structures.
Establishing The Foundation Of Collaborative Networks ; IFIP TC 5 Working Group 5.5 Eighth IFIP Working Conference on Virtual Enterprises September 10-12, 2007, Guimarães, Portugal
While today production and service provision constitute the main areas of application for Collaborative Networks (CNs) worldwide, during the last decade the paradigm is extending to many new application areas. These developments emphasize the need for establishing a sounder foundation for collaborative networks, namely in terms of theoretical principles and formal models, capturing the concepts, entities, behaviors, and operations of the CNs, and developing technology-independent infrastructure architectures, tools and methodologies. This book includ represent a comprehensive overview of recent advances in various domains and lines of research and development on collaborative networks. There is a special emphasis on the CN topics related to trust aspects, performance and value systems, VO breeding environments, VO creation, e-contracting, collaborative architectures and frameworks, professional virtual communities, interoperability issues, business benefits, and case studies and applications in industry and services.
Drug discovery and GBCR – Related CNS Disorders
Neurodegenerative diseases are a large group of neurological disorders with diverse etiological and pathological phenomena. However, current therapeutics rely mostly on symptomatic relief while failing to target the underlying disease pathobiology. G-protein-coupled receptors (GPCRs) are one of the most frequently targeted receptors for developing novel therapeutics for central nervous system (CNS) disorders. Many currently available antipsychotic therapeutics also act as either antagonists or agonists of different GPCRs. Therefore, GPCR-based drug development is spreading widely to regulate neurodegeneration and associated cognitive deficits through the modulation of canonical and noncanonical signals.
Drug delivery via nasal route
Over the past 10 years, the interest in intranasal drug delivery has increased. The objective of this research is to summarize recent developments on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, nevertheless, there are still formulation limitations and side effects to be optimized. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This research describes the anatomical, histological and physiological basis and summarizes currently approved drugs for administration via intranasal delivery. Further, the research focuses on advantages and disadvantages of intranasal applied compounds and discusses formulation aspects that need to be considered for drug development.
Drug Addiction : From Basic Research to Therapy
Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume covers the translation of basic research into novel therapies, not only of drug addiction but a spectrum of related CNS disorders, including pain. Chapters are written by leading scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and development, drug targeting, and quantitative therapeutics, providing an unprecedented overview of a complex field of high societal signficance.
Data center networking : Network topologies and traffic management in large-scale data centers
Provides a comprehensive reference in large data center networking. It first summarizes the developing trend of DCNs, and reports four novel DCNs, including a switch-centric DCN, a modular DCN, a wireless DCN, and a hybrid DCN. Furthermore another important factor in DCN targets at managing and optimizing the network activity at the level of transfers to aggregate correlated data flows and thus directly to lower down the network traffic resulting from such data transfers. In particular, the book reports the in-network aggregation of incast transfer, shuffle transfer, uncertain incast transfer, and the cooperative scheduling of uncertain multicast transfer.
Computer Network Security ; Vol. 3685
This volume contains papers presented at the 3rd International Workshop on Mathematical Methods, Models and Architectures for Computer Network - curity (MMM-ACNS 2005) held in St. Petersburg, Russia, 2005. The 1st and the 2nd International Workshops on Mathematical Methods, Models and Architectures for Computer Network Security (MMM-ACNS 2001 and MMM-ACNS 2003), hosted by the St. Petersburg Institute for Informatics and Automation, demonstrated the keen interest of the international research community in the subject area. It was recognized that conducting a biannual series of such workshops in St. Petersburg stimulates fruitful exchanges between the di?erent schools of thought, facilitates the dissemination of new ideas and promotesthespirit of cooperationbetweenresearchersontheinternationalscale. MMM-ACNS 2005 provided an international forum for sharing original - search results and application experiences among specialists in fundamental and applied problems of computer network security. An important distinction of the workshop was its focus on mathematical aspects of information and computer network security addressing the ever-increasing demands for secure computing and highly dependable computer networks.
Computer Network Security ; 4th International Conference on Mathematical Methods, Models and Architectures for Computer Network Security, MMM-ACNS 2007, St. Petersburg, Russia, September 13-15, 2007, Proceedings
This volume focus on mathematical aspects of information and computer network security addressing the ever-increasing demands for secure computing and highly dependable computer networks.
Management of Data Center Networks
Delivers a rigorous and insightful exploration of the network management challenges that present within intra- and inter-data center networks, including reliability, routing, and security. The book also discusses new architectures found in data center networks that aim to minimize the complexity of network management while maximizing Quality of Service, like Wireless/Wired DCNs, server-only DCNs, and more. offers: A thorough overview of the architectures of data center networks, including the classification of switch-centric, server-centric, enhanced, optical, and wireless DCN architectures An exploration of resource management in wired and wireless data center networks, including routing and wireless channel allocation and assignment challenges and criteria Practical discussions of inter-data center networks, including an overview of basic virtual network embedding Examinations of energy and security management in data center networks
Lippincott illustrated reviews : Pharmacology
Presents up-to-date drug information in an accessible format ideal for a fast, effective refresher. Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear, effective writing and hundreds of illustrations that break down complex information for rapid review. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation. Updated drug information reflects the most current, clinically relevant pharmacology material. Approachable outline format distills complex information for easier review. High-quality illustrations reinforce understanding in vibrant detail. Enhanced review questions with answers test students' understanding and identify areas for further study.
Knowledge Discovery in Inductive Databases ; Vol.3377 : 3rd International Workshop, KDID 2004, Pisa, Italy, September 20, 2004, Revised Selected and Invited Papers
Cnstitutes the thoroughly refereed joint postproceedings of the Third International Workshop on Knowledge Discovery in Inductive Databases, KDID 2004, held in Pisa, Italy in September 2004 in association with ECML/PKDD. Inductive Databases support data mining and the knowledge discovery process in a natural way. In addition to usual data, an inductive database also contains inductive generalizations, like patterns and models extracted from the data. This book presents nine revised full papers selected from 23 submissions during two rounds of reviewing and improvement together with one invited paper. Various current topics in knowledge discovery and data mining in the framework of inductive databases are addressed.
